Wolf-Hirschhorn Syndrome Candidate 1 (WHSC1) ELISA Kits

WHSC1 encodes a protein that contains four domains present in other developmental proteins: a PWWP domain, an HMG box, a SET domain, and a PHD-type zinc finger. Additionally we are shipping WHSC1 Antibodies (43) and WHSC1 Proteins (5) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human WHSC1 WHSC1 7468 O96028
Anti-Rat WHSC1 WHSC1 680537  
Anti-Mouse WHSC1 WHSC1 107823 Q8BVE8
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More ELISA Kits for WHSC1 Interaction Partners

Zebrafish Wolf-Hirschhorn Syndrome Candidate 1 (WHSC1) interaction partners

  1. These results indicate that DrWhsc1 is a functional homolog of WHSC1 and that the SET domain of DrWhsc1 is essential for di-methylation of histone H3K36 in zebrafish.

Human Wolf-Hirschhorn Syndrome Candidate 1 (WHSC1) interaction partners

  1. In a murine xenograft model using t(4;14)+ KMS11 MM cells harboring an inducible MMSET shRNA, depletion of MMSET enhanced the efficacy of chemotherapy, inhibiting tumor growth and extending survival.

  2. data suggest multiple myeloma SET domain containing protein(MMSET) may play a role in the inhibitory effect of metformin on prostate cancer and could serve as a potential novel therapeutic target for prostate cancer

  3. NSD2 overexpression is significantly associated with high risk of relapse and poor survival in tamoxifen-treated ER-positive breast cancer patients via coordinated activation of pentose phosphate pathway enzymes.

  4. Results show that WHSC1 is hypomethylated in cervical cancer cells and tissues. Both methylation and mRNA expression of WHSC1 were significantly correlated with lymph node metastasis and the overall survival of patients.

  5. Results showed that high levels of MMSET in the myeloma-like cells drove the formation of hypermethyled proteoforms containing H3K36me2 co-existent with the repressive marks H3K9me2/3 and H3K27me2/3.

  6. In MMSET-depleted cells there are defects in DNA replication and a decreased association with chromatin.

  7. results identify a pivotal role for NSD2 binding to its catalytic product in regulating its cellular functions, and suggest a model for how this interaction may facilitate epigenetic spreading and propagation of H3K36me2.

  8. NSD2 preferentially catalyzes the dimethylation of H3K36 along with a reduced preference for H3K36 monomethylation

  9. Studies indicate that the NSD methyltransferases NSD1 (show NSD1 ELISA Kits), NSD2/WHSC1/MMSET and NSD3/WHSC1L1 (show WHSC1L1 ELISA Kits) were overexpressed, amplified or somatically mutated in multiple types of cancer, suggesting their critical role in cancer.

  10. It was observed that RE-IIBP induces MEIS1 (show MEIS1 ELISA Kits)-mediated apoptosis, which was dependent on H2BK120 ubiquitination by RNF20 (show RNF20 ELISA Kits).

Mouse (Murine) Wolf-Hirschhorn Syndrome Candidate 1 (WHSC1) interaction partners

  1. findings highlight a pivotal link between an epigenetic regulator, WHSC1, and key intracellular signaling molecules, AKT, RICTOR, and Rac1, to drive prostate cancer metastasis.

  2. WHSC1-deficient mice display craniofacial defects that overlap with Wolf-Hirschhorn syndrome, including cochlea anomalies

  3. Histone H3 (show HIST3H3 ELISA Kits) lysine 36 methyltransferase Whsc1 promotes the association of Runx2 (show RUNX2 ELISA Kits) and p300 (show NOTCH1 ELISA Kits) in the activation of bone-related genes

  4. all of the H3K36-specific methyltransferases, including ASH1L (show ASH1L ELISA Kits), HYPB, NSD1 (show NSD1 ELISA Kits), and NSD2 were inhibited by ubH2A, whereas the other histone methyltransferases, including PRC2, G9a (show EHMT2 ELISA Kits), and Pr-Set7 (show SETD8 ELISA Kits) were not affected by ubH2A.

  5. WHSC1 links transcription elongation to HIRA (show HIRA ELISA Kits)-mediated histone H3.3 (show H3F3A ELISA Kits) deposition.

  6. H3K36me3-specific histone methyltransferase WHSC1 (also NSD2 or MMSET) functions in transcriptional regulation together with developmental transcription factors whose defects overlap with the human disease Wolf-Hirschhorn syndrome

WHSC1 Antigen Profile

Antigen Summary

This gene encodes a protein that contains four domains present in other developmental proteins: a PWWP domain, an HMG box, a SET domain, and a PHD-type zinc finger. It is expressed ubiquitously in early development. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene maps to the 165 kb WHS critical region and has also been involved in the chromosomal translocation t(4\;14)(p16.3\;q32.3) in multiple myelomas. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. Some transcript variants are nonsense-mediated mRNA (NMD) decay candidates, hence not represented as reference sequences.

Gene names and symbols associated with WHSC1

  • Wolf-Hirschhorn syndrome candidate 1 (WHSC1) antibody
  • Wolf-Hirschhorn syndrome candidate 1 (whsc1) antibody
  • Wolf-Hirschhorn syndrome candidate 1 (Whsc1) antibody
  • Wolf-Hirschhorn syndrome candidate 1 (human) (Whsc1) antibody
  • 5830445G22Rik antibody
  • 9430010A17Rik antibody
  • AW555663 antibody
  • C130020C13Rik antibody
  • D030027O06Rik antibody
  • D930023B08Rik antibody
  • fc12c04 antibody
  • mKIAA1090 antibody
  • MMSET antibody
  • NSD2 antibody
  • REIIBP antibody
  • RGD1565590 antibody
  • si:rp71-77d7.2 antibody
  • TRX5 antibody
  • WHS antibody
  • WHSC1 antibody
  • Whsc1l antibody
  • wu:fc12c04 antibody
  • wu:fi20c01 antibody

Protein level used designations for WHSC1

Wolf-Hirschhorn syndrome candidate 1 protein , Wolf-Hirschhorn syndrome candidate 1 , probable histone-lysine N-methyltransferase NSD2 , IL5 promoter REII region-binding protein , histone-lysine N-methyltransferase NSD2 , multiple myeloma SET domain containing protein type III , nuclear SET domain-containing protein 2 , trithorax/ash1-related protein 5 , multiple myeloma SET domain-containing protein , wolf-Hirschhorn syndrome candidate 1 protein homolog

461070 Pan troglodytes
540769 Bos taurus
100000709 Danio rerio
100051090 Equus caballus
100125213 Xenopus (Silurana) tropicalis
479077 Canis lupus familiaris
7468 Homo sapiens
422897 Gallus gallus
680537 Rattus norvegicus
107823 Mus musculus
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