Wolf-Hirschhorn Syndrome Candidate 1 Proteins (WHSC1)

WHSC1 encodes a protein that contains four domains present in other developmental proteins: a PWWP domain, an HMG box, a SET domain, and a PHD-type zinc finger. Additionally we are shipping WHSC1 Antibodies (41) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
WHSC1 7468 O96028
Rat WHSC1 WHSC1 680537  
WHSC1 107823 Q8BVE8
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Top WHSC1 Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$11,073.30
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$11,073.30
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human GST tag MMSET / WHSC1 - SET activity assay using Recombinant Nucleosomes as substrates. Recombinant Nucleosomes were used as substrates in an assay measuring the methyltransferase activity of MMSET / WHSC1 - SET. Activity was detected by fluorography. Recombinant MMSET / WHSC1 - SET protein gel. Recombinant MMSET / WHSC1 - SET run on an SDS-PAGE gel and stained with Coomassie blue. 50 μg Log in to see 1 to 2 Days
$466.67
Details
HOST_Baculovirus Human DYKDDDDK Tag MMSET / WHSC1 activity assay. HMT assay measuring the activity of Recombinant MMSET / WHSC1. Activity was detected by fluorography. Recombinant MMSET / WHSC1 protein gel. MMSET / WHSC1 protein was run on a 10% SDS-PAGE gel and stained with Coomassie blue. 20 μg Log in to see 1 to 2 Days
$466.67
Details

WHSC1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine)

More Proteins for Wolf-Hirschhorn Syndrome Candidate 1 (WHSC1) Interaction Partners

Zebrafish Wolf-Hirschhorn Syndrome Candidate 1 (WHSC1) interaction partners

  1. These results indicate that DrWhsc1 is a functional homolog of WHSC1 and that the SET domain of DrWhsc1 is essential for di-methylation of histone H3K36 in zebrafish.

Human Wolf-Hirschhorn Syndrome Candidate 1 (WHSC1) interaction partners

  1. data suggest multiple myeloma SET domain containing protein(MMSET) may play a role in the inhibitory effect of metformin on prostate cancer and could serve as a potential novel therapeutic target for prostate cancer

  2. NSD2 overexpression is significantly associated with high risk of relapse and poor survival in tamoxifen-treated ER-positive breast cancer patients via coordinated activation of pentose phosphate pathway enzymes.

  3. Results show that WHSC1 is hypomethylated in cervical cancer cells and tissues. Both methylation and mRNA expression of WHSC1 were significantly correlated with lymph node metastasis and the overall survival of patients.

  4. Results showed that high levels of MMSET in the myeloma-like cells drove the formation of hypermethyled proteoforms containing H3K36me2 co-existent with the repressive marks H3K9me2/3 and H3K27me2/3.

  5. In MMSET-depleted cells there are defects in DNA replication and a decreased association with chromatin.

  6. results identify a pivotal role for NSD2 binding to its catalytic product in regulating its cellular functions, and suggest a model for how this interaction may facilitate epigenetic spreading and propagation of H3K36me2.

  7. NSD2 preferentially catalyzes the dimethylation of H3K36 along with a reduced preference for H3K36 monomethylation

  8. Studies indicate that the NSD methyltransferases NSD1, NSD2/WHSC1/MMSET and NSD3/WHSC1L1 (show WHSC1L1 Proteins) were overexpressed, amplified or somatically mutated in multiple types of cancer, suggesting their critical role in cancer.

  9. It was observed that RE-IIBP induces MEIS1 (show MEIS1 Proteins)-mediated apoptosis, which was dependent on H2BK120 ubiquitination by RNF20 (show RNF20 Proteins).

  10. Results show that WHSC1 is overexpressed in Squamous cell carcinoma of the head and neck (SCCHN) and that it promotes cell-cycle progression through activation of NEK7 (show NEK7 Proteins), indicating its potential role as an oncogenic force in SCCHN.

Mouse (Murine) Wolf-Hirschhorn Syndrome Candidate 1 (WHSC1) interaction partners

  1. WHSC1-deficient mice display craniofacial defects that overlap with Wolf-Hirschhorn syndrome, including cochlea anomalies

  2. Histone H3 (show HIST3H3 Proteins) lysine 36 methyltransferase Whsc1 promotes the association of Runx2 (show RUNX2 Proteins) and p300 (show NOTCH1 Proteins) in the activation of bone-related genes

  3. all of the H3K36-specific methyltransferases, including ASH1L (show ASH1L Proteins), HYPB, NSD1, and NSD2 were inhibited by ubH2A, whereas the other histone methyltransferases, including PRC2, G9a (show EHMT2 Proteins), and Pr-Set7 (show SETD8 Proteins) were not affected by ubH2A.

  4. WHSC1 links transcription elongation to HIRA (show HIRA Proteins)-mediated histone H3.3 (show H3F3A Proteins) deposition.

  5. H3K36me3-specific histone methyltransferase WHSC1 (also NSD2 or MMSET) functions in transcriptional regulation together with developmental transcription factors whose defects overlap with the human disease Wolf-Hirschhorn syndrome

WHSC1 Protein Profile

Protein Summary

This gene encodes a protein that contains four domains present in other developmental proteins: a PWWP domain, an HMG box, a SET domain, and a PHD-type zinc finger. It is expressed ubiquitously in early development. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene maps to the 165 kb WHS critical region and has also been involved in the chromosomal translocation t(4\;14)(p16.3\;q32.3) in multiple myelomas. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. Some transcript variants are nonsense-mediated mRNA (NMD) decay candidates, hence not represented as reference sequences.

Gene names and symbols associated with WHSC1

  • Wolf-Hirschhorn syndrome candidate 1 (WHSC1)
  • Wolf-Hirschhorn syndrome candidate 1 (whsc1)
  • Wolf-Hirschhorn syndrome candidate 1 (Whsc1)
  • Wolf-Hirschhorn syndrome candidate 1 (human) (Whsc1)
  • 5830445G22Rik protein
  • 9430010A17Rik protein
  • AW555663 protein
  • C130020C13Rik protein
  • D030027O06Rik protein
  • D930023B08Rik protein
  • fc12c04 protein
  • mKIAA1090 protein
  • MMSET protein
  • NSD2 protein
  • REIIBP protein
  • RGD1565590 protein
  • si:rp71-77d7.2 protein
  • TRX5 protein
  • WHS protein
  • WHSC1 protein
  • Whsc1l protein
  • wu:fc12c04 protein
  • wu:fi20c01 protein

Protein level used designations for WHSC1

Wolf-Hirschhorn syndrome candidate 1 protein , Wolf-Hirschhorn syndrome candidate 1 , probable histone-lysine N-methyltransferase NSD2 , IL5 promoter REII region-binding protein , histone-lysine N-methyltransferase NSD2 , multiple myeloma SET domain containing protein type III , nuclear SET domain-containing protein 2 , trithorax/ash1-related protein 5 , multiple myeloma SET domain-containing protein , wolf-Hirschhorn syndrome candidate 1 protein homolog

GENE ID SPECIES
461070 Pan troglodytes
540769 Bos taurus
100000709 Danio rerio
100051090 Equus caballus
100125213 Xenopus (Silurana) tropicalis
479077 Canis lupus familiaris
7468 Homo sapiens
422897 Gallus gallus
680537 Rattus norvegicus
107823 Mus musculus
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