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XAGE1B is a member of the XAGE subfamily, which belongs to the GAGE family.
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Our results suggest that GAGE, XAGE1 (show XAGE1A Antibodies) and SSX4 (show SSX4 Antibodies) might each have a role in melanoma progression
XAGE-1b gene was able to influence angiogenesis directly or indirectly, leading to tumorigenesis and metastasis of ACC.
Recognition of XAGE-1b on OU-LU-6 tumor by the CD4 (show CD4 Antibodies)-expressing tumor-infiltrating lymphocytes was studied.
A 12-mer (show MERTK Antibodies) peptide XAGE-1b(37-48) as a new XAGE-1b epitope restricted to HLA-DRB1 (show HLA-DRB1 Antibodies)*0410 was identified.
The findings suggest that XAGE-1b and HLA class I (show MICA Antibodies) expression elicited a CD8 (show CD8A Antibodies)+ T-cell response against minimal residual disease after surgery and resulted in prolonged survival of non-small cell lung cancer patients.
This gene is a member of the XAGE subfamily, which belongs to the GAGE family. The GAGE genes are expressed in a variety of tumors and in some fetal and reproductive tissues. This gene is strongly expressed in Ewing's sarcoma, alveolar rhabdomyosarcoma and normal testis. The protein encoded by this gene contains a nuclear localization signal and shares a sequence similarity with other GAGE/PAGE proteins. Because of the expression pattern and the sequence similarity, this protein also belongs to a family of CT (cancer-testis) antigens. Alternative splicing of this gene, in addition to alternative transcription start sites, results in multiple transcript variants.
G antigen family D member 2
, X antigen family member 1
, cancer/testis antigen 12.1
, cancer/testis antigen family 12, member 1b
, cancer/testis associated protein
, protein XAGE-1