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XBP1 encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. Additionally we are shipping XBP1 Kits (32) and XBP1 Proteins (8) and many more products for this protein.
Showing 10 out of 185 products:
Human Polyclonal XBP1 Primary Antibody for EIA, WB - ABIN955595
Sudarshan, Schlegel, Liu: The HPV-16 E5 protein represses expression of stress pathway genes XBP-1 and COX-2 in genital keratinocytes. in Biochemical and biophysical research communications 2010
Show all 5 references for ABIN955595
Human Monoclonal XBP1 Primary Antibody for ELISA, WB - ABIN969462
Martino, Olsen, Fulcher, Wolfgang, ONeal, Ribeiro: Airway epithelial inflammation-induced endoplasmic reticulum Ca2+ store expansion is mediated by X-box binding protein-1. in The Journal of biological chemistry 2009
Show all 3 references for ABIN969462
Human Polyclonal XBP1 Primary Antibody for ELISA, WB - ABIN263217
Yokouchi, Hiramatsu, Hayakawa, Okamura, Du, Kasai, Takano, Shitamura, Shimada, Yao, Kitamura: Involvement of selective reactive oxygen species upstream of proapoptotic branches of unfolded protein response. in The Journal of biological chemistry 2008
Human Polyclonal XBP1 Primary Antibody for IF, WB - ABIN501132
Yoshida, Matsui, Yamamoto, Okada, Mori: XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor. in Cell 2002
Cow (Bovine) Polyclonal XBP1 Primary Antibody for WB - ABIN2780641
Davies, Barraclough, Stewart, Joyce, Eccles, Barraclough, Rudland, Sibson: Expression and splicing of the unfolded protein response gene XBP-1 are significantly associated with clinical outcome of endocrine-treated breast cancer. in International journal of cancer. Journal international du cancer 2008
Human Polyclonal XBP1 Primary Antibody for FACS, IHC (p) - ABIN651279
Navon, Gatushkin, Zelcbuch, Shteingart, Farago, Hadar, Tirosh: Direct proteasome binding and subsequent degradation of unspliced XBP-1 prevent its intracellular aggregation. in FEBS letters 2009
Overexpression of X-Box Binding Protein 1 (XBP1) Correlates to Poor Prognosis and Up-Regulation of PI3K (show PIK3CA Antibodies)/mTOR (show FRAP1 Antibodies) in Human Osteosarcoma
Overexpression of XBP1 is associated with breast cancer.
An RNA-intrinsic conformational change causes the intron of XBP1 mRNA to be ejected and the exons to zipper up into an extended stem, juxtaposing the RNA ends for ligation; These conformational rearrangements are important for XBP1 mRNA splicing in vivo
Our results reveal that IRE1alpha (show ERN1 Antibodies)-XBP1 pathway plays an important role in tumor progression and epithelial-to-mesenchymal transition (EMT (show ITK Antibodies)), and IRE1alpha (show ERN1 Antibodies) could be employed as a novel prognostic marker and a promising therapeutic target for CRC (show CALR Antibodies).
Silencing of IRE1 (show ERN1 Antibodies) expression inhibited splicing of XBP1 resulting in an early onset of cell death. In the PERK (show EIF2AK3 Antibodies)-reporter cells, authors observed that a slow rate of ATF4 (show ATF4 Antibodies)-translation and late re-initiation of general translation
these findings suggest a possible mechanism underlying the RANKL (show TNFSF11 Antibodies) expression induced by wear particles in fibroblasts, and downregulating ER stress and the XBP1s expression of fibroblasts
the present study provides initial evidence that RITA (show ZNF331 Antibodies) upregulates the expression level of IRE1a (show ERN1 Antibodies) by increasing the stability of IRE1alpha (show ERN1 Antibodies) mRNA in irradiated mtp53-expressing cervical cancer cells
review of the IRE1alpha (show ERN1 Antibodies)-XBP1 branch of the unfolded protein response in human diseases [review]
These results provide evidence that XBP-1s is a direct activator of Kaposi's sarcoma-associated herpesvirus vIL (show VIL1 Antibodies)-6 and that this is an important step in the pathogenesis of KSHV-Castleman disease and primary effusion lymphoma.
XBP-1 is required for cytokine production by inflamed human airway epithelia. Read More: http://www.atsjournals.org/doi/full/10.1164/rccm.201504-0657OC#.VwqgNdLrvyA
PKA-dependent IRE1alpha (show ERN1 Antibodies)-XBP1 activation is crucial for the transcriptional induction of Ucp1 (show UCP1 Antibodies) in brown adipocytes.
Data shsow that X-box binding protein 1 (XBP1) plays a critical role in controlling the oxidative stress in Leishmania amazonensis a-infected cells.
Diminished XBP1 and/or HNF4alpha (show HNF4A Antibodies) in beta-cells led to impaired endoplasmic reticulum calcium homeostasis.
propose that the pathology of MCDS is underpinned by XBP1 independent UPR-induced dysregulation of C/EBP-beta (show CEBPB Antibodies)-mediated chondrocyte differentiation
Data (including data from studies in knockout/transgenic mice) Xbp1 is required in mammary epithelial cells during lactation for cell proliferation (vs. apoptosis) and for development of elaborate endoplasmic reticulum (ER; without ER stress).
data indicate that hepatic XBP1 controls the adaptive response of the UPR and is critical to restoring homeostasis in the liver in response to ER stress.
Loss of XBP1 enhances liver injury in mice fed a high fat/sugar diet.
findings suggest that the balance between XBP1-mediated adaptive and CHOP (show DDIT3 Antibodies)-dependent apoptotic UPR is critically important for beta-cell survival during ER stress.
The findings reported herein indicate that palmitate-induced cisternal endoplasmic reticulum expansion is dependent on the activation of XBP-1/CCTalpha-mediated phospholipid accumulation in RAW 264.7 cells.
analyzed XBP1 level and location to explore the effect of ER stress on oocyte maturation and developmental competency of porcine embryos in an in vitro culture system
Knock-down of XBP1 enhanced endoplasmic reticulum stress-mediated cell death in porcine embryonic fibroblasts.
Exposure of endothelial cells to VEGF (show VEGFA Antibodies), high glucose, or hydrogen peroxide up-regulated the XBP1/IRE1 alpha (show ERN1 Antibodies) and ATF6 (show ATF6 Antibodies) arms of the unfolded protein response compared with untreated cells.
Expression of xbp1 is significantly upregulated in the liver of Cdipt (show CDIPT Antibodies)-deficient zebrafish due to persistent endoplasmic reticulum stress. Cdipt (show CDIPT Antibodies)-deficient zebrafish exhibits hepatic lipid accumulation.
zebrafish XBP-1 spliced form not only activates genes responsible for protein folding, transporting, glycosylation and Endoplasmic Reticulum associated degradation but also activates anti-apoptosis signal via IGF1 (show IGF1 Antibodies)/Akt (show AKT1 Antibodies) pathway in unfolded protein
XBP1 might function as an inhibitor of mesodermal and neural tissue formation by acting either as transcriptional activator or as repressor.
This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5.
X-box binding protein 1 pseudogene 1
, X-box binding protein pseudogene 1
, X-box binding protein 1
, X-box-binding protein 1
, tax-responsive element-binding protein 5
, tax-responsive element-binding protein 5 homolog
, hepatocarcinogenesis-related transcription factor
, X-box binding protein 1B