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anti-X-Box Binding Protein 1 (XBP1) Antibodies

XBP1 encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. Additionally we are shipping XBP1 Kits (32) and XBP1 Proteins (8) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
XBP1 7494 P17861
XBP1 22433 O35426
XBP1 289754 Q9R1S4
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Top anti-XBP1 Antibodies at antibodies-online.com

Showing 10 out of 219 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-XBP1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: 721_B cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-XBP1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:1562500Positive Control: Jurkat cell lysate WB Suggested Anti-XBP1  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:1562500  Positive Control: Jurkat cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Chicken Rabbit Un-conjugated WB WB Suggested Anti-XBP1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:1562500Positive Control: Jurkat cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Mouse Rabbit Un-conjugated WB XBP1 Antibody (C-term) (ABIN656725) western blot analysis in mouse lung tissue lysates (35 µg/lane). This demonstrates the XBP1 antibody detected the XBP1 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB Western blot analysis of XBP1 Antibody (Center) (ABIN651279) in Ramos cell line lysates (35 µg/lane).XBP1 (arrow) was detected using the purified polyclonal antibody. XBP1 Antibody (Center) (ABIN651279) IHC analysis in formalin fixed and paraffin embedded mouse kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining 400 μL Log in to see 10 to 11 Days
$324.50
Details
Dog Goat Un-conjugated EIA, IHC (p), WB 20 μg Log in to see 6 to 8 Days
$203.50
Details
Human Goat Un-conjugated ELISA, WB ABIN263217 (1 ug/ml) staining of nuclear HeLa lysate (35 ug protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. 100 μg Log in to see 4 to 5 Days
$318.20
Details
Human Rabbit Un-conjugated EIA, WB XBP1 Antibody (C-term) western blot analysis in mouse lung tissue lysates (35 µg/lane). This demonstrates the XBP1 antibody detected the XBP1 protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IF, WB Immunocytochemistry of XBP-1 in HepG2 cells with this product at 10 μg/ml. Western blot analysis of XBP-1 in HepG2 cell lysate with this product at (A) 0.5, (B) 1 and (C) 2 μg/ml. 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Human Mouse Un-conjugated ELISA, WB Figure 1: Western blot analysis using XBP1 mouse mAb against XBP1 (AA: 1-160) -hIgGFc transfected HEK293 cell lysate. 100 μL Log in to see 3 to 4 Days
$345.40
Details

XBP1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-XBP1 Antibodies

  1. Human Polyclonal XBP1 Primary Antibody for EIA, WB - ABIN955595 : Sudarshan, Schlegel, Liu: The HPV-16 E5 protein represses expression of stress pathway genes XBP-1 and COX-2 in genital keratinocytes. in Biochemical and biophysical research communications 2010 (PubMed)
    Show all 5 references for ABIN955595

  2. Human Monoclonal XBP1 Primary Antibody for ELISA, WB - ABIN969462 : Martino, Olsen, Fulcher, Wolfgang, ONeal, Ribeiro: Airway epithelial inflammation-induced endoplasmic reticulum Ca2+ store expansion is mediated by X-box binding protein-1. in The Journal of biological chemistry 2009 (PubMed)
    Show all 3 references for ABIN969462

  3. Human Polyclonal XBP1 Primary Antibody for ELISA, WB - ABIN263217 : Yokouchi, Hiramatsu, Hayakawa, Okamura, Du, Kasai, Takano, Shitamura, Shimada, Yao, Kitamura: Involvement of selective reactive oxygen species upstream of proapoptotic branches of unfolded protein response. in The Journal of biological chemistry 2008 (PubMed)

  4. Human Polyclonal XBP1 Primary Antibody for IF, WB - ABIN501132 : Yoshida, Matsui, Yamamoto, Okada, Mori: XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor. in Cell 2002 (PubMed)

  5. Human Polyclonal XBP1 Primary Antibody for FACS, IHC (p) - ABIN651279 : Navon, Gatushkin, Zelcbuch, Shteingart, Farago, Hadar, Tirosh: Direct proteasome binding and subsequent degradation of unspliced XBP-1 prevent its intracellular aggregation. in FEBS letters 2009 (PubMed)

  6. Cow (Bovine) Polyclonal XBP1 Primary Antibody for WB - ABIN2780641 : Davies, Barraclough, Stewart, Joyce, Eccles, Barraclough, Rudland, Sibson: Expression and splicing of the unfolded protein response gene XBP-1 are significantly associated with clinical outcome of endocrine-treated breast cancer. in International journal of cancer. Journal international du cancer 2008 (PubMed)

More Antibodies against XBP1 Interaction Partners

Human X-Box Binding Protein 1 (XBP1) interaction partners

  1. Overexpression of X-Box Binding Protein 1 (XBP1) Correlates to Poor Prognosis and Up-Regulation of PI3K (show PIK3CA Antibodies)/mTOR (show FRAP1 Antibodies) in Human Osteosarcoma

  2. Overexpression of XBP1 is associated with breast cancer.

  3. An RNA-intrinsic conformational change causes the intron of XBP1 mRNA to be ejected and the exons to zipper up into an extended stem, juxtaposing the RNA ends for ligation; These conformational rearrangements are important for XBP1 mRNA splicing in vivo

  4. Our results reveal that IRE1alpha (show ERN1 Antibodies)-XBP1 pathway plays an important role in tumor progression and epithelial-to-mesenchymal transition (EMT (show ITK Antibodies)), and IRE1alpha (show ERN1 Antibodies) could be employed as a novel prognostic marker and a promising therapeutic target for CRC (show CALR Antibodies).

  5. Silencing of IRE1 (show ERN1 Antibodies) expression inhibited splicing of XBP1 resulting in an early onset of cell death. In the PERK (show EIF2AK3 Antibodies)-reporter cells, authors observed that a slow rate of ATF4 (show ATF4 Antibodies)-translation and late re-initiation of general translation

  6. these findings suggest a possible mechanism underlying the RANKL (show TNFSF11 Antibodies) expression induced by wear particles in fibroblasts, and downregulating ER stress and the XBP1s expression of fibroblasts

  7. the present study provides initial evidence that RITA (show ZNF331 Antibodies) upregulates the expression level of IRE1a (show ERN1 Antibodies) by increasing the stability of IRE1alpha (show ERN1 Antibodies) mRNA in irradiated mtp53-expressing cervical cancer cells

  8. review of the IRE1alpha (show ERN1 Antibodies)-XBP1 branch of the unfolded protein response in human diseases [review]

  9. These results provide evidence that XBP-1s is a direct activator of Kaposi's sarcoma-associated herpesvirus vIL (show VIL1 Antibodies)-6 and that this is an important step in the pathogenesis of KSHV-Castleman disease and primary effusion lymphoma.

  10. XBP-1 is required for cytokine production by inflamed human airway epithelia. Read More: http://www.atsjournals.org/doi/full/10.1164/rccm.201504-0657OC#.VwqgNdLrvyA

Mouse (Murine) X-Box Binding Protein 1 (XBP1) interaction partners

  1. XBP1s can regulate Wnt10b (show WNT10B Antibodies) by a post-transcriptional mechanism through directly inducing microRNA-148a.

  2. PKA-dependent IRE1alpha (show ERN1 Antibodies)-XBP1 activation is crucial for the transcriptional induction of Ucp1 (show UCP1 Antibodies) in brown adipocytes.

  3. Data shsow that X-box binding protein 1 (XBP1) plays a critical role in controlling the oxidative stress in Leishmania amazonensis a-infected cells.

  4. Diminished XBP1 and/or HNF4alpha (show HNF4A Antibodies) in beta-cells led to impaired endoplasmic reticulum calcium homeostasis.

  5. propose that the pathology of MCDS is underpinned by XBP1 independent UPR-induced dysregulation of C/EBP-beta (show CEBPB Antibodies)-mediated chondrocyte differentiation

  6. these findings suggest a possible mechanism underlying the RANKL (show TNFSF11 Antibodies) expression induced by wear particles in fibroblasts, and downregulating ER stress and the XBP1s expression of fibroblasts

  7. Data (including data from studies in knockout/transgenic mice) Xbp1 is required in mammary epithelial cells during lactation for cell proliferation (vs. apoptosis) and for development of elaborate endoplasmic reticulum (ER; without ER stress).

  8. data indicate that hepatic XBP1 controls the adaptive response of the UPR and is critical to restoring homeostasis in the liver in response to ER stress.

  9. Loss of XBP1 enhances liver injury in mice fed a high fat/sugar diet.

  10. findings suggest that the balance between XBP1-mediated adaptive and CHOP (show DDIT3 Antibodies)-dependent apoptotic UPR is critically important for beta-cell survival during ER stress.

Pig (Porcine) X-Box Binding Protein 1 (XBP1) interaction partners

  1. analyzed XBP1 level and location to explore the effect of ER stress on oocyte maturation and developmental competency of porcine embryos in an in vitro culture system

  2. Knock-down of XBP1 enhanced endoplasmic reticulum stress-mediated cell death in porcine embryonic fibroblasts.

Cow (Bovine) X-Box Binding Protein 1 (XBP1) interaction partners

  1. Exposure of endothelial cells to VEGF (show VEGFA Antibodies), high glucose, or hydrogen peroxide up-regulated the XBP1/IRE1 alpha (show ERN1 Antibodies) and ATF6 (show ATF6 Antibodies) arms of the unfolded protein response compared with untreated cells.

Zebrafish X-Box Binding Protein 1 (XBP1) interaction partners

  1. Expression of xbp1 is significantly upregulated in the liver of Cdipt (show CDIPT Antibodies)-deficient zebrafish due to persistent endoplasmic reticulum stress. Cdipt (show CDIPT Antibodies)-deficient zebrafish exhibits hepatic lipid accumulation.

  2. zebrafish XBP-1 spliced form not only activates genes responsible for protein folding, transporting, glycosylation and Endoplasmic Reticulum associated degradation but also activates anti-apoptosis signal via IGF1 (show IGF1 Antibodies)/Akt (show AKT1 Antibodies) pathway in unfolded protein

Xenopus laevis X-Box Binding Protein 1 (XBP1) interaction partners

  1. XBP1 might function as an inhibitor of mesodermal and neural tissue formation by acting either as transcriptional activator or as repressor.

XBP1 Antigen Profile

Protein Summary

This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5.

Gene names and symbols associated with XBP1

  • X-box binding protein 1 (xbp1) antibody
  • X-box binding protein 1 (XBP1) antibody
  • uncharacterized LOC100719734 (LOC100719734) antibody
  • X box-binding protein active isoform (LOC100037692) antibody
  • X-box binding protein 1 (Xbp1) antibody
  • cb918 antibody
  • D11Ertd39e antibody
  • HTF antibody
  • id:ibd1195 antibody
  • TREB-5 antibody
  • TREB5 antibody
  • trebf antibody
  • wu:fb02h05 antibody
  • wu:fb63f10 antibody
  • XBP-1 antibody
  • xbp1 antibody
  • xbp1a antibody
  • xbp1b antibody
  • XBP1P1 antibody
  • XBP2 antibody
  • XBPP1 antibody
  • xXBP1 antibody

Protein level used designations for XBP1

X-box binding protein 1 pseudogene 1 , X-box binding protein pseudogene 1 , X-box binding protein 1 , X-box-binding protein 1 , tax-responsive element-binding protein 5 , tax-responsive element-binding protein 5 homolog , XBP-1 , hepatocarcinogenesis-related transcription factor , X-box binding protein 1B

GENE ID SPECIES
407858 Xenopus (Silurana) tropicalis
458735 Pan troglodytes
654272 Takifugu rubripes
100719734 Cavia porcellus
100037692 Ovis aries
7494 Homo sapiens
22433 Mus musculus
100217386 Sus scrofa
541236 Bos taurus
289754 Rattus norvegicus
140614 Danio rerio
380215 Xenopus laevis
416918 Gallus gallus
477532 Canis lupus familiaris
Selected quality suppliers for anti-XBP1 (XBP1) Antibodies
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