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X-Box Binding Protein 1 Proteins (XBP1)

XBP1 encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. Additionally we are shipping XBP1 Antibodies (192) and XBP1 Kits (32) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
XBP1 7494 P17861
Mouse XBP1 XBP1 22433 O35426
XBP1 289754 Q9R1S4
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Top XBP1 Proteins at antibodies-online.com

Showing 6 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Escherichia coli (E. coli) Human His tag 0.05 mg Log in to see 2 to 3 Days
$275.00
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,674.83
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,693.17
Details

XBP1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Rat (Rattus)

More Proteins for X-Box Binding Protein 1 (XBP1) Interaction Partners

Human X-Box Binding Protein 1 (XBP1) interaction partners

  1. Overexpression of X-Box Binding Protein 1 (XBP1) Correlates to Poor Prognosis and Up-Regulation of PI3K (show PIK3CA Proteins)/mTOR (show FRAP1 Proteins) in Human Osteosarcoma

  2. Overexpression of XBP1 is associated with breast cancer.

  3. An RNA-intrinsic conformational change causes the intron of XBP1 mRNA to be ejected and the exons to zipper up into an extended stem, juxtaposing the RNA ends for ligation; These conformational rearrangements are important for XBP1 mRNA splicing in vivo

  4. Our results reveal that IRE1alpha (show ERN1 Proteins)-XBP1 pathway plays an important role in tumor progression and epithelial-to-mesenchymal transition (EMT (show ITK Proteins)), and IRE1alpha (show ERN1 Proteins) could be employed as a novel prognostic marker and a promising therapeutic target for CRC (show CALR Proteins).

  5. Silencing of IRE1 (show ERN1 Proteins) expression inhibited splicing of XBP1 resulting in an early onset of cell death. In the PERK (show EIF2AK3 Proteins)-reporter cells, authors observed that a slow rate of ATF4 (show ATF4 Proteins)-translation and late re-initiation of general translation

  6. these findings suggest a possible mechanism underlying the RANKL (show TNFSF11 Proteins) expression induced by wear particles in fibroblasts, and downregulating ER stress and the XBP1s expression of fibroblasts

  7. the present study provides initial evidence that RITA (show ZNF331 Proteins) upregulates the expression level of IRE1a (show ERN1 Proteins) by increasing the stability of IRE1alpha (show ERN1 Proteins) mRNA in irradiated mtp53-expressing cervical cancer cells

  8. review of the IRE1alpha (show ERN1 Proteins)-XBP1 branch of the unfolded protein response in human diseases [review]

  9. These results provide evidence that XBP-1s is a direct activator of Kaposi's sarcoma-associated herpesvirus vIL (show VIL1 Proteins)-6 and that this is an important step in the pathogenesis of KSHV-Castleman disease and primary effusion lymphoma.

  10. XBP-1 is required for cytokine production by inflamed human airway epithelia. Read More: http://www.atsjournals.org/doi/full/10.1164/rccm.201504-0657OC#.VwqgNdLrvyA

Mouse (Murine) X-Box Binding Protein 1 (XBP1) interaction partners

  1. XBP1s can regulate Wnt10b (show WNT10B Proteins) by a post-transcriptional mechanism through directly inducing microRNA-148a.

  2. PKA-dependent IRE1alpha (show ERN1 Proteins)-XBP1 activation is crucial for the transcriptional induction of Ucp1 (show UCP1 Proteins) in brown adipocytes.

  3. Data shsow that X-box binding protein 1 (XBP1) plays a critical role in controlling the oxidative stress in Leishmania amazonensis a-infected cells.

  4. Diminished XBP1 and/or HNF4alpha (show HNF4A Proteins) in beta-cells led to impaired endoplasmic reticulum calcium homeostasis.

  5. propose that the pathology of MCDS is underpinned by XBP1 independent UPR-induced dysregulation of C/EBP-beta (show CEBPB Proteins)-mediated chondrocyte differentiation

  6. these findings suggest a possible mechanism underlying the RANKL (show TNFSF11 Proteins) expression induced by wear particles in fibroblasts, and downregulating ER stress and the XBP1s expression of fibroblasts

  7. Data (including data from studies in knockout/transgenic mice) Xbp1 is required in mammary epithelial cells during lactation for cell proliferation (vs. apoptosis) and for development of elaborate endoplasmic reticulum (ER; without ER stress).

  8. data indicate that hepatic XBP1 controls the adaptive response of the UPR and is critical to restoring homeostasis in the liver in response to ER stress.

  9. Loss of XBP1 enhances liver injury in mice fed a high fat/sugar diet.

  10. findings suggest that the balance between XBP1-mediated adaptive and CHOP (show DDIT3 Proteins)-dependent apoptotic UPR is critically important for beta-cell survival during ER stress.

Pig (Porcine) X-Box Binding Protein 1 (XBP1) interaction partners

  1. analyzed XBP1 level and location to explore the effect of ER stress on oocyte maturation and developmental competency of porcine embryos in an in vitro culture system

  2. Knock-down of XBP1 enhanced endoplasmic reticulum stress-mediated cell death in porcine embryonic fibroblasts.

Cow (Bovine) X-Box Binding Protein 1 (XBP1) interaction partners

  1. Exposure of endothelial cells to VEGF (show VEGFA Proteins), high glucose, or hydrogen peroxide up-regulated the XBP1/IRE1 alpha (show ERN1 Proteins) and ATF6 (show ATF6 Proteins) arms of the unfolded protein response compared with untreated cells.

Zebrafish X-Box Binding Protein 1 (XBP1) interaction partners

  1. Expression of xbp1 is significantly upregulated in the liver of Cdipt (show CDIPT Proteins)-deficient zebrafish due to persistent endoplasmic reticulum stress. Cdipt (show CDIPT Proteins)-deficient zebrafish exhibits hepatic lipid accumulation.

  2. zebrafish XBP-1 spliced form not only activates genes responsible for protein folding, transporting, glycosylation and Endoplasmic Reticulum associated degradation but also activates anti-apoptosis signal via IGF1 (show IGF1 Proteins)/Akt (show AKT1 Proteins) pathway in unfolded protein

Xenopus laevis X-Box Binding Protein 1 (XBP1) interaction partners

  1. XBP1 might function as an inhibitor of mesodermal and neural tissue formation by acting either as transcriptional activator or as repressor.

XBP1 Protein Profile

Protein Summary

This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5.

Gene names and symbols associated with X-Box Binding Protein 1 Proteins (XBP1)

  • X-box binding protein 1 (xbp1)
  • X-box binding protein 1 (XBP1)
  • uncharacterized LOC100719734 (LOC100719734)
  • X box-binding protein active isoform (LOC100037692)
  • X-box binding protein 1 (Xbp1)
  • cb918 protein
  • D11Ertd39e protein
  • HTF protein
  • id:ibd1195 protein
  • TREB-5 protein
  • TREB5 protein
  • trebf protein
  • wu:fb02h05 protein
  • wu:fb63f10 protein
  • XBP-1 protein
  • xbp1 protein
  • xbp1a protein
  • xbp1b protein
  • XBP1P1 protein
  • XBP2 protein
  • XBPP1 protein
  • xXBP1 protein

Protein level used designations for X-Box Binding Protein 1 Proteins (XBP1)

X-box binding protein 1 pseudogene 1 , X-box binding protein pseudogene 1 , X-box binding protein 1 , X-box-binding protein 1 , tax-responsive element-binding protein 5 , tax-responsive element-binding protein 5 homolog , XBP-1 , hepatocarcinogenesis-related transcription factor , X-box binding protein 1B

GENE ID SPECIES
407858 Xenopus (Silurana) tropicalis
458735 Pan troglodytes
654272 Takifugu rubripes
100719734 Cavia porcellus
100037692 Ovis aries
7494 Homo sapiens
22433 Mus musculus
100217386 Sus scrofa
541236 Bos taurus
289754 Rattus norvegicus
140614 Danio rerio
380215 Xenopus laevis
416918 Gallus gallus
477532 Canis lupus familiaris
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