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XAF1 encodes a protein which binds to and counteracts the inhibitory effect of a member of the IAP (inhibitor of apoptosis) protein family. Additionally we are shipping XAF1 Antibodies (92) and XAF1 Proteins (5) and many more products for this protein.
Dysfunction of XAF1 is frequent and is regulated through XAF1 promoter hypermethylation in gastric cancer. Circulating methylated XAF1 DNA was associated with tumor burden and malignant progression, which may be a valuable biomarker for diagnosis of gastric cancer, predicting patients' prognosis and monitoring tumor recurrence after surgery treatment.
XAF1 promoter hypomethylation is associated with high-grade gliomas.
human genome-wide gene expression profile assay was used to screen the targets of miR (show MLXIP ELISA Kits)-3131. The overexpressed miR (show MLXIP ELISA Kits)-3131 could lead to a significant decrease of DTHD1 and XAF1 mRNA level.
XAF1 acts as a feedback regulator of the TNF (show TNF ELISA Kits) receptor signaling pathway to suppress NF-kappaB (show NFKB1 ELISA Kits) activation
Taken together, our results suggest that ROS (show ROS1 ELISA Kits) generation might be a predisposing event in berberine-induced mitochondrial apoptosis in EBV-transformed B cells through the upregulation of XAF1 and GADD45alpha (show GADD45A ELISA Kits) expression by MAPK (show MAPK1 ELISA Kits) and functional p53 (show TP53 ELISA Kits).
Expression of XAF1 and TAp73 (show TP73 ELISA Kits) was also upregulated in casticin-treated T24 cells.
Data show that X-linked inhibitor of apoptosis protein (XIAP (show XIAP ELISA Kits)) mRNA and protein expression increased, whereas XIAP-associated factor 1 (XAF1) mRNA and protein expression decreased with the growth of radiation dose and exposure time.
the present study was the first to construct an adenovirus which coexpressed XAF1 and TNFalpha (show TNF ELISA Kits) in the same open reading frame and expressed them proportionally. As AdXAF1&TNFalpha (show TNF ELISA Kits) inhibited HCC (show FAM126A ELISA Kits) cells with enhanced efficiency, it may be applicable for the treatment of HCC (show FAM126A ELISA Kits).
SHC1 (show SHC1 ELISA Kits) regulates the alternative splicing of XAF1 in extracellular matrix-detachment induced autophagy to coordinate with the anoikic cell death.
Our study identified a novel splice variant of XAF1 in cancer cells
Interferon gamma (show IFNG ELISA Kits) induces XAF1 and Noxa (show PMAIP1 ELISA Kits) expression and potentiates apoptosis by STAT3 (show STAT3 ELISA Kits) activation
XAF1 possesses a potential antiangiogenesis effect. Suppressed expression of Tie-1 (show TIE1 ELISA Kits), Ang-1 (show ANGPT1 ELISA Kits), Ang-2 (show ANGPT2 ELISA Kits) and c-Myc (show MYC ELISA Kits) may be mechanistically responsible for the observed antiangiogenesis effect.
This gene encodes a protein which binds to and counteracts the inhibitory effect of a member of the IAP (inhibitor of apoptosis) protein family. IAP proteins bind to and inhibit caspases which are activated during apoptosis. The proportion of IAPs and proteins which interfere with their activity, such as the encoded protein, affect the progress of the apoptosis signaling pathway. Multiple transcript variants encoding different isoforms have been found for this gene.
XIAP-associated factor 1
, BIRC4 binding protein
, BIRC4-binding protein
, F-box protein 39
, novel TRAF-type zinc finger protein