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The protein encoded by YME1L1 is the human ortholog of yeast mitochondrial AAA metalloprotease, Yme1p. Additionally we are shipping YME1-Like 1 (S. Cerevisiae) Antibodies (23) and YME1-Like 1 (S. Cerevisiae) Kits (2) and many more products for this protein.
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Data suggest that in a mouse model of neonatal hypoxic-ischemic brain injury, the expression of mitochondrial shaping proteins, such as OPA1 and Yme1L, are altered; in vitro and in vivo, OPA1 is cleaved to shorter forms and Yme1L expression is reduced.
Constitutive OPA1 cleavage by YME1L and OMA1 (show OMA1 Proteins) at two distinct sites leads to the accumulation of both long and short forms of OPA1 and maintains mitochondrial fusion.
These results identify mutations in YME1L1 as a cause of a mitochondriopathy with optic nerve atrophy highlighting the importance of YME1L1 for mitochondrial functionality in humans.
YME1L1 was identified as the first NUMT (nuclear mtDNA) suppressor gene in human and demonstrate that inactivation of YME1L1 induces migration of mtDNA to the nuclear genome.
differential stress-induced degradation of YME1L and OMA1 (show OMA1 Proteins) as a mechanism for sensitively adapting mitochondrial inner membrane protease activity and function in response to distinct types of cellular insults.
YME1L degradation reduces mitochondrial proteolytic capacity during oxidative stress.Loss of YME1L compromises the regulation of mitochondrial inner membrane proteostasis.
Results reveal a crucial role for YME1L in the maintenance of mitochondrial inner-membrane proteostasis and in the proteolytic regulation of respiratory chain biogenesis.
The protein encoded by this gene is the human ortholog of yeast mitochondrial AAA metalloprotease, Yme1p. It is localized in the mitochondria and can functionally complement a yme1 disruptant yeast strain. It is proposed that this gene plays a role in mitochondrial protein metabolism and could be involved in mitochondrial pathologies. Three transcript variants encoding different isoforms have been found for this gene.
ATP-dependent metalloprotease FtsH1
, ATP-dependent zinc metalloprotease YME1L1
, YME1-like protein 1
, ATP-dependent metalloprotease FtsH1 homolog
, ATP-dependent metalloprotease YME1L1
, presenilin-associated metalloprotease