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binds nuclear transcriptosomal complex scaffold attachment factor B (SAF-B) and Sam68\; may play a role in splice site selection and alternative splicing [RGD, Feb 2006].. Additionally we are shipping YTHDC1 Antibodies (7) and many more products for this protein.
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Results show that YTHDC1 promotes exon inclusion in targeted mRNAs through recruiting pre-mRNA splicing factor (show SNRPB Proteins) SRSF3 (show SRSF3 Proteins) while blocking SRSF10 (show SRSF10 Proteins) mRNA binding.
The YTHDC1-binding sites and biochemical experiments, not only reveal the specific mode of m(6)A-YTH binding but also explain the preferential recognition of the GG(m(6)A)C sequences by YTHDC1.
Hypoxia induces a specific switch in YT521 expression pattern towards the two non-protein coding mRNA variants, the already characterized isoform 3 and the newly discovered exon 8-skipping isoform.
Studied mRNA levels of FOXO1 (show FOXO1 Proteins), KLF9 (show KLF9 Proteins) and YT521 in human normal and cancerous endometrial tissue. A remarkable (not significant, p = 0.069) increase was found in the YT521 mRNA level of patients' endometrial tissue in comparison with the control subjects.
Lack of YT521 protein is associated with endometrial cancer.
YT521-B has a role in a gene expression in the pathogenesis of Emery-Dreifuss muscular dystrophy
phosphorylation causes sequestration of YT521-B in an insoluble nuclear form, which is unable to change splice sites
binds nuclear transcriptosomal complex scaffold attachment factor B (SAF-B) and Sam68\; may play a role in splice site selection and alternative splicing
YTH domain containing 1
, splicing factor YT521-B
, YTH domain-containing protein 1
, putative splicing factor YT521
, RA301-binding protein