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binds nuclear transcriptosomal complex scaffold attachment factor B (SAF-B) and Sam68\; may play a role in splice site selection and alternative splicing [RGD, Feb 2006].. Additionally we are shipping YTHDC1 Antibodies (8) and YTHDC1 Proteins (3) and many more products for this protein.
Results show that YTHDC1 promotes exon inclusion in targeted mRNAs through recruiting pre-mRNA splicing factor SRSF3 while blocking SRSF10 mRNA binding.
The YTHDC1-binding sites and biochemical experiments, not only reveal the specific mode of m(6)A-YTH binding but also explain the preferential recognition of the GG(m(6)A)C sequences by YTHDC1.
Hypoxia induces a specific switch in YT521 expression pattern towards the two non-protein coding mRNA variants, the already characterized isoform 3 and the newly discovered exon 8-skipping isoform.
Studied mRNA levels of FOXO1 (show FOXO1 ELISA Kits), KLF9 (show KLF9 ELISA Kits) and YT521 in human normal and cancerous endometrial tissue. A remarkable (not significant, p = 0.069) increase was found in the YT521 mRNA level of patients' endometrial tissue in comparison with the control subjects.
Lack of YT521 protein is associated with endometrial cancer.
YT521-B has a role in a gene expression in the pathogenesis of Emery-Dreifuss muscular dystrophy
phosphorylation causes sequestration of YT521-B in an insoluble nuclear form, which is unable to change splice sites
binds nuclear transcriptosomal complex scaffold attachment factor B (SAF-B) and Sam68\; may play a role in splice site selection and alternative splicing
YTH domain containing 1
, splicing factor YT521-B
, YTH domain-containing protein 1
, putative splicing factor YT521
, RA301-binding protein