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YTHDF2 encodes a member of the YTH (YT521-B homology) superfamily containing YTH domain. Additionally we are shipping YTHDF2 Proteins (2) and many more products for this protein.
Showing 9 out of 16 products:
Human Polyclonal YTHDF2 Primary Antibody for EIA, WB - ABIN955619
Cardelli, Marchegiani, Cavallone, Olivieri, Giovagnetti, Mugianesi, Moresi, Lisa, Franceschi: A polymorphism of the YTHDF2 gene (1p35) located in an Alu-rich genomic domain is associated with human longevity. in The journals of gerontology. Series A, Biological sciences and medical sciences 2006
Show all 2 references for ABIN955619
The study presents the structure of YTH-YTHDF2 in complex with an N6-methyladenosine mononucleotide.
The basic residues K416 and R527 on the surface of the YTH domain of YTHDF2 are involved in binding to the RNA backbone, and residues W432 and W486 within the hydrophobic pocket contribute to the specific recognition of N6-methyladenosine.
m(6)A is selectively recognized by the human YTH domain family 2 (YTHDF2) 'reader' protein to regulate mRNA degradation
PMID:10508479 reported that AF155095 (clone REN-2) may be involved in signal transduction and the gene is on chromosome 14. It turns out that it is the pseudogene, not the real gene, is located on chromosome 14.
YTHDF2 messenger RNA resulted to be mainly expressed in testis (show XKR3 Antibodies) and placenta. The data suggest a possible role of this locus in human longevity.
This gene encodes a member of the YTH (YT521-B homology) superfamily containing YTH domain. The YTH domain is typical for the eukaryotes and is particularly abundant in plants. The YTH domain is usually located in the middle of the protein sequence and may function in binding to RNA. In addition to a YTH domain, this protein has a proline rich region which may be involved in signal transduction. An Alu-rich domain has been identified in one of the introns of this gene, which is thought to be associated with human longevity. In addition, reciprocal translocations between this gene and the Runx1 (AML1) gene on chromosome 21 has been observed in patients with acute myeloid leukemia. This gene was initially mapped to chromosome 14, which was later turned out to be a pseudogene. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.
YTH domain family, member 2
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, high-glucose-regulated protein 8
, renal carcinoma antigen NY-REN-2