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Involved in the reprogramming of X-chromosome inactivation during the acquisition of pluripotency.
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Results show that a novel pluripotency regulator, REX1 (show REXO1 Antibodies), is essential for pluripotency and reprogramming.
hRex1 binds to the hRex1 promoter region at -298 bp and positively regulates hRex1 transcription, but this regulation is lost in PC-3 (show PCSK1 Antibodies) human prostate cancer cells.
REX1 (show REXO1 Antibodies) functions in normal adult epithelial cells and tumorigenic stem cells.
Data show that Oct-4 (show POU5F1 Antibodies), Rex-1, and Gata-4 (show GATA4 Antibodies) expression in human mesenchymal stem cells increases cell differentiation efficiency but not hTERT expression.
MAPCs express the OCT4 (show POU5F1 Antibodies) and REX1 (show REXO1 Antibodies) transcription factors, two specific markers of undifferentiated embryonic stem (ES) cells.
Rex1 (show REXO1 Antibodies) plays a role during preimplantation development (show MTA2 Antibodies) and alters expression levels of Zscan4 (show ZSCAN4 Antibodies).
Results show that Rex1 (show REXO1 Antibodies) regulates endogenous retroviral element expression in mouse embryonic stem cells and during pre-implantation development and suggest that Rex1 (show REXO1 Antibodies) and its relatives have evolved as regulators of endogenous retroviral transcription.
RNF12 (show RLIM Antibodies) causes REX1 (show REXO1 Antibodies) breakdown through dose-dependent catalysis, thereby representing an important pathway to initiate X-chromosome inactivation
the involvement of Rex-1 in control of Polycomb (show CBX2 Antibodies) target genes during pluripotency or differentiation.
loss of Rex1 (show REXO1 Antibodies) leads to impaired testicular function.
the functional connection of Rex1 (show REXO1 Antibodies) to genomic imprinting represents another case where newly made genes have co-evolved with lineage-specific phenomena.
Embryonic stem cell marker Rex-1 and the pluripotent stem cell marker Oct-4 (show POU5F1 Antibodies) are spontaneously expressed by untreated mesenchymal stem cells.
Rex1 (show REXO1 Antibodies), which is highly expressed in stem cells, inhibits signaling via the Janus kinase (JAK (show JAK3 Antibodies))/signal transducer and activator of transcription (STAT (show STAT1 Antibodies)) pathway, thereby modulating the differentiation of F9 cells.
Rex1 (show REXO1 Antibodies) should be regarded just as a marker of pluripotency without functional significance
Involved in the reprogramming of X-chromosome inactivation during the acquisition of pluripotency. Required for efficient elongation of TSIX, a non-coding RNA antisense to XIST. Binds DXPas34 enhancer within the TSIX promoter. Involved in ES cell self-renewal.
, REX1 transcription factor
, reduced expression protein 1
, zinc finger protein 42 homolog
, zinc finger protein 754