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The protein encoded by ZFP57 is a zinc finger protein containing a KRAB domain.
transient neonatal diabetes type 1 is associated with ZFP57 mutations
ZFP57 regulates the expression of insulin-like growth factor 2 (IGF2 (show IGF2 Antibodies)), which has a critical role in ZFP57-induced anchorage-independent growth
High grade glioblastoma is associated with increased level of ZFP57, a protein involved in gene imprinting, and aberrant expression of CPT1A (show CPT1A Antibodies) and CPT1C (show CPT1C Antibodies).
These data identify ZFP57 as a candidate gene underlying reported MHC disease associations, notably for putative regulatory variants associated with cancer and HIV-1.
Mouse and human ZFP57 are orthologs despite relatively low sequence identity.
ZFP57 vZFP57 vZFP57
no evidence for ZFP57 alterations as a major cause in sporadic Beckwith-Wiedemann Syndrome cases
this study does not provide evidence that ZFP57 mutations are the cause of 11p15-hypomethylation in Silver-Russell syndrome (SRS (show SMS Antibodies)) patients and contribute to the aetiology of SRS (show SMS Antibodies)
Study reports mutations in ZFP57, which encodes a zinc-finger transcription factor (show OSR1 Antibodies) expressed in early development, in seven pedigrees with a shared pattern of mosaic hypomethylation and a conserved range of clinical features.
Data show that ZFP57 binding is affected by single nucleotide polymorphism (SNPs) and closely associated TGCCGC motif sequences that are present at the target sites.
Within established mouse imprinted clusters, ZFP57 specifically binds known or predicted imprinting control region elements, but does not interact with secondary somatically differentially methylated regions (DMRs) or germline DMRs that are not imprinting controlling.
ZFP57 may modulate NOTCH (show NOTCH1 Antibodies) signaling during cardiac development.
Taken together, our results suggest that Nanog (show NANOG Antibodies) positively regulates Zfp57 expression in multiple types of cells.
Data suggest that Glu182 in the DNA binding site in zinc finger motif of Zfp57 plays important role in binding specificity and affinity for 5-carboxylcytosine and other cytosine analogs.
the structure of the DNA-binding domain of Zfp57, consisting of two adjacent zinc fingers, in complex with fully methylated DNA
ZFP57 may recruit DNA methyltransferases to its target regions to maintain DNA methylation (show HELLS Antibodies) imprint, and this interaction is likely facilitated by KAP1/TRIM28/TIF1beta (show TRIM28 Antibodies).
In embryonic stem cells, ZFP57/KAP1 (show TRIM28 Antibodies) recognize a methylated hexanucleotide to affect chromatin and DNA methylation (show HELLS Antibodies) of imprinting control regions.
The protein encoded by this gene is a zinc finger protein containing a KRAB domain. Studies in mouse suggest that this protein may function as a transcriptional repressor. Mutations in this gene have been associated with transient neonatal diabetes mellitus type 1 (TNDM1).
, zinc finger protein 57 homolog
, zinc finger protein 698
, KRAB box-like