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ZIC2 Proteins (ZIC2)

ZIC2 encodes a member of the ZIC family of C2H2-type zinc finger proteins. Additionally we are shipping ZIC2 Antibodies (46) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ZIC2 7546 O95409
Rat ZIC2 ZIC2 361096  
Mouse ZIC2 ZIC2 22772  
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Top ZIC2 Proteins at

Showing 2 out of 2 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 19 Days

ZIC2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,

More Proteins for ZIC2 Interaction Partners

Human ZIC2 interaction partners

  1. Data show that Zinc finger protein ZIC 2 (ZIC2) is indispensable in the regulation of pancreatic ductal adenocarcinoma (PDAC) cell apoptosis.

  2. ZIC2 acts upstream of OCT4 (show POU5F1 Proteins) and recruits the nuclear remodeling factor complex to the OCT4 (show POU5F1 Proteins) promoter, initiating OCT4 (show POU5F1 Proteins) activation. ZIC2 levels positively correlated to the clinicopathological stages of HCC (show FAM126A Proteins) patients.

  3. Mutational screening for HPE genes revealed the occurrence of a frameshift mutation in the ZIC2 gene.

  4. ZIC2 and RASGRF1 (show RASGRF1 Proteins) are susceptibility genes, not only for common myopia, but also for high myopia.

  5. The c.1401_1406dup (p.Ala469_470dup) or alanine tract expansion to 17 residues) in the ZIC2 gene are likely to be medically significant for holoprosencephaly in a Brazilian cohort.

  6. A high level of sequence variation in the 3'UTR of ZIC2 may be associated with holoprosencephaly.

  7. ZIC2, a transcription factor related to the sonic hedgehog (show SHH Proteins) pathway, is a strong discriminant between MAL (show MAL Proteins) and LMP (show PDLIM7 Proteins) tumors: it may be a major determinant of outcome of EOTs.

  8. Mutations in ZIC2 is associated with holoprosencephaly.

  9. Brain malformations, including neuronal migration defects, predominated in individuals with ZIC2 mutations.

  10. role for ZIC2 as a transcriptional regulator of the beta-catenin.TCF4 complex.

Zebrafish ZIC2 interaction partners

  1. Zic2a and Zic2b play a dual role during craniofacial development, in neural crest induction and migration, and in craniofacial chondrogenesis patterning

  2. Zic2a and Zic5 have essential, cooperative roles in promoting cell proliferation in the tectum, but lack obvious patterning functions.

  3. the results identify Zic2a as a novel regulator of prethalamic development, and show that it functions independently of hedgehog (show SHH Proteins) signaling.

  4. Zic2a and zic5 as crucial players in the genetic network linking patterned gene expression to morphogenetic changes during neurulation.

  5. These data uncover a novel, essential role for Zic2a as a modulator of Hedgehog (show SHH Proteins)-activated gene expression in the developing forebrain

Mouse (Murine) ZIC2 interaction partners

  1. Here, we reveal a previously unknown role for Zic2 in the migration of forebrain neurons such as Cajal-Retzius cells, interneurons moving to the ventral lateral geniculate nucleus, and neocortical cells going to the amygdala.

  2. Zic1 (show ZIC1 Proteins) and Zic2 are required for coordinating mature neuronal gene expression patterns.

  3. Zic2 loss-of-function doesn't prevent initial otocyst patterning but leads to molecular abnormalities concomitant with morphogenesis of the endolymphatic duct.

  4. Zic2 is a key factor in the execution of transcriptional fine-tuning with Mbd3 (show MBD3 Proteins)/NuRD in embryonic stem cells through interactions with enhancers.

  5. Zic2 appears to be a component of the gene regulatory network that drives ciliation of node cells during gastrulation.

  6. results reveal a Zic2-dependent mechanism, shared by different neural populations, essential to prevent midline crossing during the development of the nervous system.

  7. Explant culture of Zic2(m1Nisw) gastrointestinal tract show extensive neurite outgrowth, suggesting that Zic2 is a negative regulator of nerve fiber growth.

  8. Among three novel missense mutations in ZIC2, R409P was only found in schizophrenia patients, and was located in a strongly conserved position of the zinc finger domain.

  9. Myf5 (show MYF5 Proteins) activation in newly forming somites is delayed in Zic2 mutant embryos until the time of Zic1 (show ZIC1 Proteins) activation, and both Zic2 and Myf5 (show MYF5 Proteins) require noggin (show NOG Proteins) for their activation

  10. Zic2 is an evolutionarily conserved determinant of retinal ganglion cells that project ipsilaterally

ZIC2 Protein Profile

Protein Summary

This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. This protein functions as a transcriptional repressor and may regulate tissue specific expression of dopamine receptor D1. Mutations in this gene cause holoprosencephaly type 5. Holoprosencephaly is the most common structural anomaly of the human brain. A polyhistidine tract polymorphism in this gene may be associated with increased risk of neural tube defects. This gene is closely linked to a gene encoding zinc finger protein of the cerebellum 5, a related family member on chromosome 13.

Gene names and symbols associated with ZIC2 Proteins (ZIC2)

  • Zic family member 2 (ZIC2)
  • Zic family member 2 (Zic2)
  • zic family member 2 (odd-paired homolog, Drosophila), a (zic2a)
  • zinc finger protein of the cerebellum 2 (Zic2)
  • cb851 protein
  • fb26a03 protein
  • HPE5 protein
  • Ku protein
  • wu:fb26a03 protein
  • zic2 protein
  • zic2.1 protein

Protein level used designations for ZIC2 Proteins (ZIC2)

Zic family member 2 (odd-paired homolog, Drosophila) , Zinc finger protein of the cerebellum 2 , zinc finger protein ZIC 2 , cerebellum zinc finger protein 2 , zinc finger protein of the cerebellum 2 , zinc finger cerebellum 2 , GENA 29 , kumba , odd-paired homolog

7546 Homo sapiens
485533 Canis lupus familiaris
361096 Rattus norvegicus
467311 Pan troglodytes
428021 Gallus gallus
100062051 Equus caballus
514433 Bos taurus
100622978 Sus scrofa
58077 Danio rerio
22772 Mus musculus
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