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anti-ZNFN1A2 (ZNFN1A2) Antibodies

ZNFN1A2 encodes a member of the Ikaros family of zinc-finger proteins. Additionally we are shipping ZNFN1A2 Proteins (4) and ZNFN1A2 Kits (1) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
ZNFN1A2 22779 P81183
ZNFN1A2 301476  
ZNFN1A2 22807 Q9UKS7
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Top anti-ZNFN1A2 Antibodies at

Showing 10 out of 90 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Chicken Rabbit Un-conjugated WB WB Suggested Anti-IKZF2 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: Transfected 293T 100 μL Log in to see 2 to 3 Days
Chicken Rabbit Un-conjugated IHC, WB WB Suggested Anti-ZNFN1A2 Antibody Titration: 5.0ug/mlELISA Titer: 1:62500Positive Control: HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
Xenopus laevis Rabbit Un-conjugated WB Transfected 293T; WB Suggested Anti-IKZF2 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:312500. Positive Control: Transfected 293T; IKZF2 antibody - middle region in Transfected 293T cells using Western Blot 50 μg Log in to see 6 to 8 Days
Human Rabbit Un-conjugated ELISA, WB   100 μg Log in to see 2 to 3 Days
Human Hamster Un-conjugated FACS Human peripheral blood lymphocytes were stained with anti-CD4 Pacific 0.1 mg Log in to see 4 to 5 Days
Human Hamster PE FACS Human peripheral blood lymphocytes were stained with anti-CD4 Pacific 100 Tests Log in to see 4 to 5 Days
Human Rabbit Un-conjugated IHC, WB 100 μg Log in to see 8 to 10 Days
Human Rabbit Un-conjugated WB HeLa cell lysates probed with Rabbit Anti-ZNFN1A2 Polyclonal Antibody, Unconjugated (ABIN2180458) at 1:300 overnight at 4 °C. Followed by conjugation to secondary antibody  at 1:5000 for 90 min at 37 °C. 100 μL Log in to see 14 to 21 Days
Human Armenian Hamster FITC FACS 100 Tests Log in to see 10 to 12 Days
Human Rabbit Un-conjugated IHC, ELISA, WB 100 μg Log in to see 2 to 3 Days

ZNFN1A2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Mouse (Murine) ,
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Rat (Rattus)

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Top referenced anti-ZNFN1A2 Antibodies

  1. Human Monoclonal ZNFN1A2 Primary Antibody for FACS - ABIN2749147 : Atarashi, Tanoue, Oshima, Suda, Nagano, Nishikawa, Fukuda, Saito, Narushima, Hase, Kim, Fritz, Wilmes, Ueha, Matsushima, Ohno, Olle, Sakaguchi, Taniguchi, Morita, Hattori, Honda: Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota. in Nature 2013 (PubMed)
    Show all 5 references for ABIN2749147

  2. Human Monoclonal ZNFN1A2 Primary Antibody for FACS - ABIN2749084 : Pinheiro, Singh, Grant, Appleton, Sacchini, Walker, Chadbourne, Palmer, Armitage-Chan, Thompson, Williamson, Cunningham, Garden: Phenotypic and functional characterization of a CD4(+) CD25(high) FOXP3(high) regulatory T-cell population in the dog. in Immunology 2010 (PubMed)
    Show all 4 references for ABIN2749084

  3. Chicken Polyclonal ZNFN1A2 Primary Antibody for WB - ABIN2774209 : Antica, Cicin-Sain, Sain, Kapitanovic, Matulic, Dzebro, Dominis: Aberrant Ikaros, Aiolos, and Helios expression in Hodgkin and non-Hodgkin lymphoma. in Blood 2008 (PubMed)

  4. Human Polyclonal ZNFN1A2 Primary Antibody for ELISA, WB - ABIN1451847 : Choudhary, Kumar, Gnad, Nielsen, Rehman, Walther, Olsen, Mann: Lysine acetylation targets protein complexes and co-regulates major cellular functions. in Science (New York, N.Y.) 2009 (PubMed)

  5. Chicken Polyclonal ZNFN1A2 Primary Antibody for IHC, WB - ABIN2777408 : Hahm, Cobb, McCarty, Brown, Klug, Lee, Akashi, Weissman, Fisher, Smale: Helios, a T cell-restricted Ikaros family member that quantitatively associates with Ikaros at centromeric heterochromatin. in Genes & development 1998 (PubMed)

More Antibodies against ZNFN1A2 Interaction Partners

Mouse (Murine) ZNFN1A2 interaction partners

  1. Helios controls certain aspects of Treg-suppressive function, differentiation, and survival.

  2. this study reports that impaired expression of the transcription factor Helios by FoxP3 (show FOXP3 Antibodies)+ CD4 (show CD4 Antibodies) and Qa-1 (show H2-T23 Antibodies)-restricted CD8 (show CD8A Antibodies) Tregs results in defective regulatory activity and autoimmunity in mice.

  3. data suggest that a subset of DN T cells, identified by the expression of PD-1 (show PDCD1 Antibodies) and Helios, represent self-reactive cells; results provide an explanation for the origin of DN T cells and introduce CD8 (show CD8A Antibodies) loss as a process associated with self-Ag encounter

  4. results demonstrate that Helios is expressed by thymic and peripheral T cells that are being driven to tolerance in response to a genuine autoantigen

  5. identify Helios as the first marker known to diverge during positive and negative selection of thymocytes

  6. Helios regulates IL-2 (show IL2 Antibodies) production in Tregs by suppressing Il2 (show IL2 Antibodies) gene transcription. Loss of Helios in Tregs breaks their anergic phenotype and results in derepression of the Il2 (show IL2 Antibodies) locus.

  7. Helios expression spatially coincides with the early pattern of expression of the mature markers of striatal projection neurons.

  8. In tumor-bearing mice, Helios(+) regulatory T cells were relatively over-represented in the tumor-mass.

  9. Data found that Helios-negative T cells are enriched for naive T cell phenotypes and vice versa. Moreover, Helios can be induced during T cell activation and proliferation, but regresses in the same cells under resting conditions.

  10. down-regulation of NK cell activity by NKp46 (show NCR1 Antibodies) was associated with the silencing of the Helios transcription factor in NK cells

Human ZNFN1A2 interaction partners

  1. The results show that high vs. low expression of Nrp-1 (show NELL1 Antibodies) or Helios does not unequivocally identify Treg clones of thymic or peripheral origin.

  2. Helios could be considered a more reliable marker for distinguishing thymic derived Regulatory T (tTreg) cells or peripherally induced Treg cells than Nrp1 (show NELL1 Antibodies).

  3. Forkhead box (show FOXO Antibodies) protein 3 (show HSPB3 Antibodies)(+) regulatory T cells and Helios(+) subset in perinatally acquired HIV.

  4. The immunosuppressive enzyme IL4I1 (show IL4I1 Antibodies) expressed differentially in human induced Aiolos (show IKZF3 Antibodies)+, but not natural Helios+, FOXP3 (show FOXP3 Antibodies)+ Treg cells.

  5. Ectopic expression of ATL-type Helios isoform as well as knockdown of normal Helios or Ikaros (show IKZF1 Antibodies) promoted T-cell growth.

  6. Foxp3 (show FOXP3 Antibodies)+ Helios+ regulatory T cells are expanded in active systemic lupus erythematosus.

  7. large number of ex vivo expanded functional Treg can be obtained from long-term T1D patients, although fewer expanded Treg expressed a high level of Helios

  8. A differential role for monocyte subsets in control of Helios(+/-) Treg development that is mediated by distinct inflammatory cytokines.

  9. Although Ikaros (show IKZF1 Antibodies) and Helios belong to the same family with similar structure of zinc fingers, their isoforms have different expression profiles, specific genetic alterations, and different clinical relevance in patients with leukemia.

  10. Helios+ and Helios- cells coexist within the natural FOXP3 (show FOXP3 Antibodies)+ T regulatory cell subset in humans.

ZNFN1A2 Antigen Profile

Protein Summary

This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This protein forms homo- or hetero-dimers with other Ikaros family members, and is thought to function predominantly in early hematopoietic development. Multiple transcript variants encoding different isoforms have been found for this gene, but the biological validity of some variants has not been determined.

Gene names and symbols associated with anti-ZNFN1A2 (ZNFN1A2) Antibodies

  • IKAROS family zinc finger 2 (Helios) (IKZF2) antibody
  • IKAROS family zinc finger 2 (Helios) (ikzf2) antibody
  • IKAROS family zinc finger 2 (Ikzf2) antibody
  • A730095J18Rik antibody
  • ANF1A2 antibody
  • HELIOS antibody
  • IKZF2 antibody
  • Zfpn1a2 antibody
  • ZNF1A2 antibody
  • znfn1a1 antibody
  • znfn1a1-a antibody
  • Znfn1a2 antibody

Protein level used designations for anti-ZNFN1A2 (ZNFN1A2) Antibodies

IKAROS family zinc finger 2 (Helios) , zinc finger protein, subfamily 1A, 2 (Helios) , ikaros family zinc finger protein 2 , zinc finger protein Helios , ikaros-related transcription factor , lymphoid transcription factor , zinc finger DNA binding protein Helios

470634 Pan troglodytes
693521 Macaca mulatta
100144703 Xenopus (Silurana) tropicalis
22779 Mus musculus
301476 Rattus norvegicus
373693 Xenopus laevis
395309 Gallus gallus
22807 Homo sapiens
488510 Canis lupus familiaris
Selected quality suppliers for anti-ZNFN1A2 (ZNFN1A2) Antibodies
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