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ZFAND2B encodes a protein containing AN1-type zinc-fingers and ubiquitin-interacting motifs. Additionally we are shipping Zinc Finger, AN1-Type Domain 2B Antibodies (35) and many more products for this protein.
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Study demonstrates specificity of AIRAPL for Lys48-linked tri-ubiquitin chains triggered by intrinsic selectivity of its double-sided UIM (UIM2) for Lys48 linkage and a flexible inter-UIM linker that results in an overall conformation which confers simultaneous binding of tUIMs to three consecutive ubiquitin moieties in a Lys48-linked chain.
AIRAPL-deficient mice develop a fully-penetrant myeloproliferative neoplastic process via dysregulation of IGF1/IGF1R.
Results demonstrate that on specific translocation inhibition, a p97 (show EIF4G2 Proteins)-AIRAPL complex directly binds and regulates the efficient processing of polyubiquitinated pQC substrates by the UPS. Results also demonstrate p97 (show EIF4G2 Proteins)'s role in pQC processing of preproinsulin (show INS Proteins) in cases of naturally occurring mutations within the signal sequence of insulin (show INS Proteins).
Consistent with its proposed role as a tumor suppressor of myeloid transformation, AIRAPL expression is widely abrogated in human myeloproliferative disorders.
AIRAPL binds to p97 (show EIF4G2 Proteins) and forms a complex in the endoplasmic reticulum membrane.
An AIP-1 (show BIRC3 Proteins) human homologue, ZFAND2B, has a similar protective effect against Abeta (show APP Proteins) toxicity.
This gene encodes a protein containing AN1-type zinc-fingers and ubiquitin-interacting motifs. The encoded protein likely associates with the proteosome to stimulate the degradation of toxic or misfolded proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
, AN1-type zinc finger protein 2B
, arsenite-inducible RNA-associated protein-like protein