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Zinc Finger, DHHC-Type Containing 17 Proteins (ZDHHC17)

Palmitoyltransferase specific for a subset of neuronal proteins, including SNAP25, DLG4/PSD95, GAD2, SYT1 and HD. Additionally we are shipping Zinc Finger, DHHC-Type Containing 17 Antibodies (44) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Mouse ZDHHC17 ZDHHC17 320150 Q80TN5
ZDHHC17 23390 Q8IUH5
Rat ZDHHC17 ZDHHC17 366889  
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Top Zinc Finger, DHHC-Type Containing 17 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details

ZDHHC17 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,

More Proteins for Zinc Finger, DHHC-Type Containing 17 (ZDHHC17) Interaction Partners

Mouse (Murine) Zinc Finger, DHHC-Type Containing 17 (ZDHHC17) interaction partners

  1. The findings of this study identify ZDHHC17 as an important upstream factor of ERK1/2 to regulate the interaction between TrkA (show NTRK1 Proteins) and tubulin (show TUBB Proteins) during neuronal development.

  2. Data show that the ankyrin repeat (AR) domains of S-acyltransferases zDHHC17 and zDHHC13 (show ZDHHC13 Proteins) recognize peptide sequence in several unrelated proteins.

  3. Loss of Hip14 and Hip14l (show ZDHHC13 Proteins) leads to early embryonic lethality at day embryonic day 10-11 due to failed chorioallantoic fusion.

  4. Data indicate that thioesterases APT1 (show FAS Proteins)/APT2 (show TAP2 Proteins) depalmitoylate nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2 (show NMNAT2 Proteins)) and zDHHC17 is the strongest candidate palmitoyltransferase for NMNAT2 (show NMNAT2 Proteins).

  5. In the absence of HIP14, striatal neurons become dysfunctional, leading to impaired motor behavior.

  6. The constitutive absence of Hip14/DHHC17 results in major neurophysiological deficits and associated cognitive dysfunction.

  7. altered palmitoylation mediated by HIP14 may contribute to HD.

  8. Wild-type HTT (show HTT Proteins) modulates the enzymatic activity of the neuronal palmitoyl transferase HIP14.

  9. Immunohistochemical analysis of pancreatic sections demonstrated that HIP14 is almost exclusively expressed in insulin (show INS Proteins)-positive cells in islets of Langerhans.

  10. Downregulation of HIP14 in mouse neurons expressing wild-type and mutant htt (show HTT Proteins) increases inclusion formation, whereas overexpression of HIP14 substantially reduces inclusions

Human Zinc Finger, DHHC-Type Containing 17 (ZDHHC17) interaction partners

  1. This suggests that altered HIP14-HTT (show HTT Proteins) and HIP14L (show ZDHHC13 Proteins)-HTT (show HTT Proteins) interactions in the presence of the HD mutation reduces palmitoylation and promotes mislocalization of HTT (show HTT Proteins) and other HIP14/HIP14L (show ZDHHC13 Proteins) substrates

  2. Data show that deletion of huntingtin (show HTT Proteins) protein (HTT (show HTT Proteins)) amino acids 1-427 abolishes the interaction of HTT (show HTT Proteins) with palmitoyl acyltransferases huntingtin interacting protein 14 (HIP14) and huntingtin interacting protein 14-like (HIP14L (show ZDHHC13 Proteins)).

  3. HIP14 shares a high proportion of interactors with HTT (show HTT Proteins) resulting in defective palmitoylation of the target proteins which might be an important mechanism towards pathogenesis of Huntington's disease.

  4. DHHC17 is a ClipR-59 (show CLIP3 Proteins) palmitoyltransferase that modulates ClipR-59 (show CLIP3 Proteins) plasma membrane binding.

  5. Low levels of human HIP14 are sufficient to rescue neuropathological, behavioural, and enzymatic defects due to loss of murine HIP14 in Hip14-/- mice.

  6. Immunohistochemical analysis of pancreatic sections demonstrated that HIP14 is almost exclusively expressed in insulin (show INS Proteins)-positive cells in islets of Langerhans.

  7. Novel peptides have been developed that target the jun (show JUN Proteins) N-terminus kinase (JNK (show MAPK8 Proteins))-interacting motif on zD17 to selectively block enhancement of the zD17-Jun (show JUN Proteins) N terminus kinase (JNK (show MAPK8 Proteins)) interaction and the activation of JNK (show MAPK8 Proteins) isoforms 2 and 3.

  8. a subset of DHHCs controls STREX palmitoylation and function; DHHC17 may preferentially target cysteine-rich domains

  9. Coexpression of an independent palmitoyl acyltransferase (HIP14) with the GODZ-DHHS mutant also rescued Ca(2 (show CA2 Proteins)+) transport.

  10. HIP14 is a protein: palmitoyl acyltransferase

Zinc Finger, DHHC-Type Containing 17 (ZDHHC17) Protein Profile

Protein Summary

Palmitoyltransferase specific for a subset of neuronal proteins, including SNAP25, DLG4/PSD95, GAD2, SYT1 and HD. May be involved in the sorting or targeting of critical proteins involved in the initiating events of endocytosis at the plasma membrane. Has transforming activity. Mediates Mg(2+) transport (By similarity).

Gene names and symbols associated with ZDHHC17

  • zinc finger, DHHC-type containing 17 (ZDHHC17)
  • zinc finger, DHHC-type containing 17 (zdhhc17)
  • zinc finger, DHHC domain containing 17 (Zdhhc17)
  • zinc finger, DHHC-type containing 17 (Zdhhc17)
  • A230053P19Rik protein
  • BB187739 protein
  • D130071N24Rik protein
  • HIP3 protein
  • HIP14 protein
  • HYPH protein
  • si:ch211-81a6.1 protein

Protein level used designations for ZDHHC17

zinc finger, DHHC-type containing 17 , huntingtin interacting protein 14 , palmitoyltransferase ZDHHC17-like , DHHC-17 , huntingtin-interacting protein 14 , palmitoyltransferase ZDHHC17 , zinc finger DHHC domain-containing protein 17 , HIP-14 , HIP-3 , Huntingtin interacting protein H , huntingtin interacting protein 3 , huntingtin yeast partner H , huntingtin-interacting protein 3 , huntingtin-interacting protein H , putative MAPK-activating protein PM11 , putative NF-kappa-B-activating protein 205 , zinc finger, DHHC domain containing 17 , membrane-associated DHHC17 zinc finger protein

GENE ID SPECIES
452088 Pan troglodytes
693595 Macaca mulatta
100059245 Equus caballus
100348308 Oryctolagus cuniculus
100441489 Pongo abelii
100482435 Ailuropoda melanoleuca
100486328 Xenopus (Silurana) tropicalis
100538815 Meleagris gallopavo
100566493 Anolis carolinensis
100597842 Nomascus leucogenys
320150 Mus musculus
23390 Homo sapiens
100148543 Danio rerio
417867 Gallus gallus
541172 Bos taurus
366889 Rattus norvegicus
482574 Canis lupus familiaris
100514712 Sus scrofa
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