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Rab4/Rab5 effector protein acting in early endocytic membrane fusion and membrane trafficking of recycling endosomes.
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Chicken Polyclonal ZFYVE20 Primary Antibody for WB - ABIN2781181
Beausoleil, Villén, Gerber, Rush, Gygi: A probability-based approach for high-throughput protein phosphorylation analysis and site localization. in Nature biotechnology 2006
Human Polyclonal ZFYVE20 Primary Antibody for ELISA, WB - ABIN185061
Nielsen, Christoforidis, Uttenweiler-Joseph, Miaczynska, Dewitte, Wilm, Hoflack, Zerial: Rabenosyn-5, a novel Rab5 effector, is complexed with hVPS45 and recruited to endosomes through a FYVE finger domain. in The Journal of cell biology 2000
A functional defect in the endocytic pathway resulting from a point mutation in Rabenosyn-5 leads to severe multi-organ disorder.
transferrin (show Tf Antibodies) receptors are delivered selectively from clathrin-coated pits on the plasma membrane into a specific subpopulation of endosomes enriched in the multivalent Rab GTPase (show RAB6A Antibodies) and phosphoinositide-binding protein (show ARAP3 Antibodies) Rabenosyn-5.
Data implicate hVps45 and Rabenosyn-5 in post early endosome transport, and suggest that their interaction serves as a nexus to promote bidirectional transport along the endosome-to-recycling compartment and endosome-to-Golgi axes.
results demonstrate that even the structurally similar effector domains in rabenosyn-5 can achieve highly selective recognition of distinct subsets of Rab (show HRB Antibodies) GTPases exclusively through interactions with the switch and interswitch regions
Rab4/Rab5 effector protein acting in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Required for endosome fusion either homotypically or with clathrin coated vesicles. Plays a role in the lysosomal trafficking of CTSD/cathepsin D from the Golgi to lysosomes. Also promotes the recycling of transferrin directly from early endosomes to the plasma membrane. Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate (PtdInsP3) (By similarity).
FYVE-finger-containing Rab5 effector protein rabenosyn-5
, zinc finger, FYVE domain containing 20
, 110 kDa protein
, FYVE finger-containing Rab5 effector protein rabenosyn-5
, zinc finger FYVE domain-containing protein 20