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ZFYVE26 encodes a protein which contains a FYVE zinc finger binding domain. Additionally we are shipping Zinc Finger, FYVE Domain Containing 26 Antibodies (14) and many more products for this protein.
we describe an uncharacterized cellular mechanism for Suf/Spastizin activity during secretion, which raises the possibility of novel therapeutic avenues for HSP research.
spastizin and spatacsin (show SPG11 ELISA Kits) were essential components for the initiation of lysosomal tubulation. Together, these results link dysfunction of the autophagy/lysosomal biogenesis machinery to neurodegeneration.
ZFYVE26 is a key determinant of autophagosome maturation
spg15 should be search for in the case of juvenile levodopa reponsive parkinsonism
We propose AP-5 (show AP5B1 ELISA Kits), SPG15, SPG11 (show SPG11 ELISA Kits) form a coat-like complex, with AP-5 (show AP5B1 ELISA Kits) involved in protein sorting, SPG15 facilitating docking of the coat onto membranes by interacting with PI3P via its FYVE domain, and SPG11 (show SPG11 ELISA Kits) (possibly together with SPG15) forming a scaffold.
spastizin interacts with the autophagy related Beclin 1-UVRAG-Rubicon multiprotein complex and is required for autophagosome maturation.
SPG15 was strongly expressed in cortical and spinal motor neurons and in embryos. It partially co-localized with multiple organelles, particularly with protein-trafficking vesicles, endoplasmic reticulum, microtubules and the mitochondria surface.
Findings suggest a positive feedback loop for recruitment of FYVE-CENT and Beclin 1 (show BECN1 ELISA Kits) to the intercellular bridge during cytokinesis, and reveal a novel potential tumor suppressor mechanism for Beclin 1 (show BECN1 ELISA Kits).
PtdIns(3)P production is essential for proper cytokinesis. PtdIns(3)P-binding centrosomal protein FYVE-CENT and TTC19 (show TTC19 ELISA Kits) control cytokinesis through their translocation from the centrosome to the midbody mediated by the kinesin protein KIF13A (show KIF13A ELISA Kits).
phenotypic heterogeneity of SPG15 in which mental retardation or cognitive deterioration, but not all other signs of Kjellin syndrome, are associated with hereditary spastic paraplegia and significantly reduces the SPG15 locus
Autosomal recessive HSP-TCC (show SFXN1 ELISA Kits) is a frequent subtype of complicated HSP in Tunisia and is clinically and genetically heterogeneous. SPG11 (show SPG11 ELISA Kits) and SPG15 are the major loci for this entity.
Increased levels of lysosomal enzymes in brains of aged knockout mice further support an alteration of the lysosomal compartment upon disruption of Zfyve26
This gene encodes a protein which contains a FYVE zinc finger binding domain. The presence of this domain is thought to target these proteins to membrane lipids through interaction with phospholipids in the membrane. Mutations in this gene are associated with autosomal recessive spastic paraplegia-15.
, zinc finger, FYVE domain containing 26
, zinc finger FYVE domain-containing protein 26-like
, FYVE domain-containing centrosomal protein
, zinc finger FYVE domain-containing protein 26