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The protein encoded by ZMYM2 is a zinc finger protein that may act as a transcription factor. Additionally we are shipping ZMYM2 Antibodies (45) and and many more products for this protein.
In this report we described the first successful development of a model of human ZMYM2-FGFR1 (show FGFR1 ELISA Kits) driven AML (show RUNX1 ELISA Kits) in immunocompromised mice, which shows an etiology consistent with the development of the primary human disease.
Multi-SUMO binding is mediated through multi-SIM (show SIM2 ELISA Kits) modules, and the functional importance of these interactions is demonstrated for the transcriptional corepressor ZMYM2/ZNF198
downregulation of SUZ12 (show SUZ12 ELISA Kits) and ZNF198 leads to epigenetic reprogramming of infected hepatocytes. Because both Plk1 (show PLK1 ELISA Kits) and HOTAIR are elevated in many human cancers, we propose that their combined effects are involved in epigenetic reprogramming
B-lymphoblastic leukemia/lymphoma associated with t(8;13)(p11 (show S100A10 ELISA Kits);q12)/ ZMYM2 (ZNF198)-FGFR1 (show FGFR1 ELISA Kits)
We propose Plk1 (show PLK1 PLURAL_@22317@) activity down-regulates ZNF198 and SUZ12 (show SUZ12 PLURAL_@22317@), thereby enhancing both HBV replication and pX-mediated oncogenic transformation.
cell transformation mediated by ZNF198-FGFR1 (show FGFR1 ELISA Kits) requires STAT5 (show STAT5A ELISA Kits) activation
ZNF198/fibroblast growth factor receptor-1 (show FGFR1 ELISA Kits) has signaling function comparable with interleukin-6 (show IL6 ELISA Kits) cytokine receptors.
SUMO-1 (show SUMO1 ELISA Kits), PML (show PML ELISA Kits) and ZNF198 colocalize to punctate structures, shown by immunocytochemistry to be PML (show PML ELISA Kits) bodies.
ZNF198-FGFR1 (show FGFR1 ELISA Kits) activated both the AKT (show AKT1 ELISA Kits) and mitogen activated protein kinase (show MAPK1 ELISA Kits) (MAPK (show MAPK1 ELISA Kits)) prosurvival signaling pathways, resulting in elevated phosphorylation of the AKT (show AKT1 ELISA Kits) target FOXO3a (show FOXO3 ELISA Kits) at T32 and BAD at S112, respectively.
HSPA1A (show HSPA1A ELISA Kits) is an important regulator of the stability and function of ZNF198 and its oncogenic derivative, ZNF198-FGFR1 (show FGFR1 ELISA Kits).
The study demonstrates frequent, constitutive activation of Notch1 (show NOTCH1 ELISA Kits) and its downstream target genes in T-cell lymphomas that arose in a murine model of Zmym2-Fgfr1 (show FGFR1 ELISA Kits) stem cell leukemia-lymphoma syndrome.
The protein encoded by this gene is a zinc finger protein that may act as a transcription factor. The encoded protein may be part of a BHC histone deacetylase complex. Translocation of this gene with the fibroblast growth factor receptor-1 gene (FGFR1) results in a fusion gene, which may be a cause of stem cell leukemia lymphoma syndrome (SCLL). Several transcript variants encoding the same protein have been found for this gene.
zinc finger, MYM-type 2
, zinc finger protein 198
, fused in myeloproliferative disorders protein
, rearranged in an atypical myeloproliferative disorder
, zinc finger MYM-type protein 2
, MYM-type zinc finger protein 2