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ZC3HAV1 encodes a CCCH-type zinc finger protein that is thought to prevent infection by retroviruses. Additionally we are shipping ZC3HAV1 Antibodies (25) and many more products for this protein.
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S-farnesylation is crucial for targeting the long-isoform of ZAP to endolysosomes and enhancing the antiviral activity of this immune effector.
ZAP inhibits M2 expression and regulates the maintenance of MHV-68 latency
Herpes simplex virus 1 UL41 was shown for the first time to evade the antiviral function of human ZAP via its RNase activity.
The association of the ZAP ribonucleoprotein particle with many interferon (show IFNA Proteins)-stimulated gene products indicates it may be a key player in the interferon (show IFNA Proteins) response.
Suppressing Matrin 3 powers a heightened and broader ZAP restriction of HIV-1 gene expression.
PARP13 regulates RNA in stress and disease. [review]
PARP13 regulates cellular mRNA post-transcriptionally and functions as a pro-apoptotic factor by destabilizing TRAILR4 (show TNFRSF10D Proteins) transcript.
results show that PARP13 lacks the structural requirements for ADP-ribosyltransferase activity
Contrary to previous assumptions, these results indicate an essential function of the PARP-like domain in hZAP-L's antiviral activity.
Data suggest that two isoforms of ZAP (ZAP-long and -short) inhibit replication of hepatitis B virus and replication of viral DNA in hepatocytes through posttranscriptional down-regulation of viral RNA.
This gene encodes a CCCH-type zinc finger protein that is thought to prevent infection by retroviruses. Studies of the rat homolog indicate that the protein may primarily function to inhibit viral gene expression and induce an innate immunity to viral infection. Alternative splicing occurs at this locus and two variants, each encoding distinct isoforms, are described.
ADP-ribosyltransferase diphtheria toxin-like 13
, zinc finger CCCH-type antiviral protein 1
, CCCH-type zinc finger antiviral protein (Zap)
, zinc finger antiviral protein
, zinc finger CCCH domain-containing protein 2