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ZC3H12A is an MCP1 (CCL2\; MIM 158105)-induced protein that acts as a transcriptional activator and causes cell death of cardiomyocytes, possibly via induction of genes associated with apoptosis.[supplied by OMIM, Mar 2008].. Additionally we are shipping ZC3H12A Proteins (4) and ZC3H12A Kits (1) and many more products for this protein.
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Human Polyclonal ZC3H12A Primary Antibody for EIA, IHC (p) - ABIN955634
Skalniak, Mizgalska, Zarebski, Wyrzykowska, Koj, Jura: Regulatory feedback loop between NF-kappaB and MCP-1-induced protein 1 RNase. in The FEBS journal 2009
Show all 5 references for ABIN955634
Human Polyclonal ZC3H12A Primary Antibody for EIA, WB - ABIN501151
Zhou, Azfer, Niu, Graham, Choudhury, Adamski, Younce, Binkley, Kolattukudy: Monocyte chemoattractant protein-1 induces a novel transcription factor that causes cardiac myocyte apoptosis and ventricular dysfunction. in Circulation research 2006
Overexpression of MCPIP1 induced apoptosis.
MCPIP1 is the target of mmu-miR (show MLXIP Antibodies)-27-5p.
MCPIP1-MSCs also expressed increased levels of proteins involved in angiogenesis, autophagy, and induction of differentiation
This studies demonstrated that MCPIP1 is an important mediator of minocycline-induced protection from brain ischemia.
Data indicate that MCPIP1 (also termed Regnase-1, encoded by Zc3h12a) knockdown enhanced interleukin-17 (IL-17 (show IL17A Antibodies))-mediated signaling.
MCPIP expression in the ischemic myocardium protects against adverse cardiac remodeling and dysfunction following myocardial infarction
both in vivo and in vitro experiments demonstrate that the transcription factors STAT6 (show STAT6 Antibodies) and KLF4 (show KLF4 Antibodies) implement IL-4 (show IL4 Antibodies)-induced M2 polarization via the dual catalytic activities of MCPIP.
Findings reveal that differential regulation of mRNAs by Regnase-1 and Roquin (show RC3H1 Antibodies) depends on their translation status and enables elaborate control of inflammation.
Roquin (show RC3H1 Antibodies) inhibited T(H)17 cell differentiation and acted together with the endoribonuclease regnase-1 to repress target mRNA encoding the T(H)17 cell-promoting factors IL-6 (show IL6 Antibodies), ICOS (show ICOS Antibodies), c-Rel (show NFkBP65 Antibodies), IRF4 (show IRF4 Antibodies), IkappaBNS (show NFKBID Antibodies) and IkappaBzeta (show NFKBIZ Antibodies).
MCPIP1 deficiency in mice results in severe anemia related to autoimmune mechanisms.
findings provide novel insight into the potential targeting of MCPIP1 or autophagy in the development of potential therapeutic strategies for silicosis
These findings reveal a new potential function of MCPIP1, suggesting a possible mechanism of fibrosis in pulmonary silicosis.
The human conserved stem-loop structure is not sufficient for ZC3H12A-dependent degradation.
expression of miR (show MLXIP Antibodies)-3613-3p might be regulated by MCPIP1 by cleavage of its precursor form.
Suggest that MCPIP1 may play an important role in cholesterol induced damage in endothelial cells.
Findings show increased MCP1P expression in a model of Ischemia/Reperfusion Injury (I/R) and suggest a vital role for MCPIP1 in cell migration and apoptosis, resulting in increased angiogenesis and apoptosis during the late stages of I/R.
In white blood cells from patients with SLE, MCPIP1 expression was elevated, and its expression correlated positively with the IFN score and negatively with the miR (show MLXIP Antibodies)-146a transcript level.
demonstrated induction of MCPIP1 in human fibroblasts embedded in the stress-released 3-D collagen matrix, which occurred through activation of mitogen-activated protein kinases, phosphoinositide 3-kinase, and NF-kappaB (show NFKB1 Antibodies)
In this review we summarize current progress regarding the specific characteristics of sequences and structures in the 3' untranslated regions of mRNAs that are recognized by tristetraproline (show ZFP36 Antibodies), Roquins, and Regnase-1.
miR (show MLXIP Antibodies)-139-mediated downregulation of MCPIP1 promotes IL-6 (show IL6 Antibodies) expression in osteoarthritis.
ZC3H12A is an MCP1 (CCL2\; MIM 158105)-induced protein that acts as a transcriptional activator and causes cell death of cardiomyocytes, possibly via induction of genes associated with apoptosis.
zinc finger CCCH-type containing 12A
, MCP-1 treatment-induced protein
, MCP-induced protein 1
, ribonuclease ZC3H12A
, zinc finger CCCH domain-containing protein 12A
, Zinc finger CCCH domain-containing protein 12A
, MCP induced protein 1