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ZFHX3 encodes a transcription factor with multiple homeodomains and zinc finger motifs, and regulates myogenic and neuronal differentiation. Additionally we are shipping ZFHX3 Kits (3) and and many more products for this protein.
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Human Polyclonal ZFHX3 Primary Antibody for IHC, ELISA - ABIN1533928
Martin, Han, Gordon, Terry, Prabhakar, She, Xie, Hellsten, Chan, Altherr, Couronne, Aerts, Bajorek, Black, Blumer, Branscomb, Brown, Bruno, Buckingham, Callen, Campbell, Campbell, Campbell, Caoile et al.: The sequence and analysis of duplication-rich human chromosome 16. ... in Nature 2004
The results suggest an additive effect of ZFHX3 and PTEN (show PTEN Antibodies) deletions on the development and progression of prostate neoplasia
Both ZFHX3 and PITX2c (show PITX2 Antibodies) regulate expression of NPPA (show NPPA Antibodies), TBX5 (show TBX5 Antibodies) and NKX2.5 (show NKX2-5 Antibodies).
In a Caucasian population, genetic variant rs7193343 SNP in ZFHX3 gene is associated with risk of atrial fibrillation.
Study found increased levels of ATBF1 in the cytoplasm of hippocampal pyramidal neurons in Alzheimer's disease brains and that ATBF1 binds to the C-terminal of A-beta (show SUCLA2 Antibodies)-PP, increasing the steady state levels of A-beta (show SUCLA2 Antibodies)-PP and resulting in increased A-beta (show SUCLA2 Antibodies) production
The CAA (show TSHZ1 Antibodies) repeat polymorphism in exon 9 of the ZFHX3 gene contributes to the Coronary heart disease susceptibility in the Chinese population.
ZFHX3 defects are associated with poor outcome in endometroid endometrial cancer.
Two SNPs (rs2106261, rs6499600) located in gene ZFHX3 showed significant associations with atrial fibrillation in a Chinese Han population.
ZFHX3 transcription is regulated in a transcript-specific fashion by independent cis (show CISH Antibodies)-acting transcribed polymorphisms.
A missense mutation in ZFHX3 results in damage to the ZFHX3 protein structure in patients with extreme atrial fibrillation.
nuclear localization and SUMOylation are important for the transcription factor function of ATBF1, and that ATBF1 could cooperate with PML (show PML Antibodies) NBs (show NBN Antibodies) to regulate protein SUMOylation in different biological processes.
ZFHX3 knock-down in atrial myocytes dysregulated calcium homeostasis and increased atrial arrhythmogenesis.
Data show that knock-out of zinc finger homeobox 3 (ZFHX3) interrupted lactogenesis, resulting in underdeveloped glands.
These findings provide in vivo evidence that ATBF1 is a tumor suppressor in the prostate
These data indicate that tachypacing decreased ATBF1, leading to enhanced STAT3 (show STAT3 Antibodies) DNA-binding activity due to the reduced formation of a binary complex of ATBF1 and PIAS3 (show PIAS3 Antibodies).
findings indicate that Atbf1 plays a role in the development of pubertal mammary gland likely by modulating the function of estrogen-ER signaling in luminal cells and by modulating gene expression in basal cells
Atbf1 heterozygous mice displayed reduced body weight, preweaning mortality, increased cell proliferation, and attenuated cytokeratin 18 (show KRT18 Antibodies) expression, indicating haploinsufficiency of Atbf1.
these results demonstrate that these phosphorylation sites on ATBF1 function as a defensive shield to calpain-1 (show CAPN1 Antibodies).
A novel signaling pathway that links ATM (show ATM Antibodies) via CREB (show CREB1 Antibodies) to the transcription factor ZFHX3, which in turn promotes survival of neurons by inducing expression of platelet-derived growth factor receptor beta (show PDGFRB Antibodies), is reported.
Atbf1, serves as a novel pituitary regulator for one of the two required enhancers as shown by genetic and in vitro analysis
This gene encodes a transcription factor with multiple homeodomains and zinc finger motifs, and regulates myogenic and neuronal differentiation. The encoded protein suppresses expression of the alpha-fetoprotein gene by binding to an AT-rich enhancer motif. The protein has also been shown to negatively regulate c-Myb, and transactivate the cell cycle inhibitor cyclin-dependent kinase inhibitor 1A (also known as p21CIP1). This gene is reported to function as a tumor suppressor in several cancers, and sequence variants of this gene are also associated with atrial fibrillation. Multiple transcript variants expressed from alternate promoters and encoding different isoforms have been found for this gene.
zinc finger homeobox 3
, zinc finger homeobox protein 3-like
, AT-binding transcription factor 1
, AT-binding transcription factor1
, AT motif-binding factor 1
, alpha-fetoprotein enhancer binding protein
, alpha-fetoprotein enhancer-binding protein
, zinc finger homeobox protein 3
, zinc finger homeodomain protein 3
, AT motif binding factor 1
, AT motif-binding factor