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ZFX on the X chromosome is structurally similar to a related gene on the Y chromosome. Additionally we are shipping ZFX Antibodies (36) and ZFX Proteins (2) and many more products for this protein.
Zfx is a common cell-intrinsic regulator of diverse Hedgehog (show SHH ELISA Kits)-induced tumors.
Zfx, a transcription factor that controls hematopoietic stem cell self-renewal, controls the initiation and maintenance of acute myeloid leukemia (show BCL11A ELISA Kits).
These studies identify Zfx as a shared transcriptional regulator of embryonic stem cells and hematopoietic stem cells, suggesting a common genetic basis of self-renewal in embryonic and adult SC.
Zfx restrains the stress response and couples antigen receptor signaling to cell expansion and maintenance during B-cell development and peripheral homeostasis
colon cancer-associated transcript-1 knockdown inhibits proliferation and invasion of laryngeal squamous cell cancer cells through enhancing zinc finger protein, X-linked by sponging microRNA-218, elucidating a novel colon cancer-associated transcript-1-microRNA-218-zinc finger protein, X-linked regulatory axis in laryngeal squamous cell cancer and providing a promising therapeutic target for laryngeal cancer
EZH2 and ZFX genes do not seem to have an impact on the onset of most parathyroid tumours, both benign and malignant, though further studies on larger cohorts of different ethnicity are needed.
Zinc finger and X-linked factor ZFX transactivates the SET transcript 2 promoter through binding to a site closely located to the transcription start site.
ZFX is over-expressed in HCC (show FAM126A ELISA Kits) cells, and correlates with stem cell-like features and pleiotropic characteristics
miR (show MLXIP ELISA Kits)-144 has been demonstrated to act as a tumour suppressor in hepatocellular carcinoma (HCC (show FAM126A ELISA Kits)) cell growth and motility by directly targeting ZFX, which implicates its potential applications in the development of HCC (show FAM126A ELISA Kits) treatment
demonstrated that ZFX is aberrantly expressed in multiple human leukemic cells and it modulates the growth and drug response of leukemic cells partially via B4GALT1, which suggests that ZFX is a new regulator of leukemic cells and warrants intensive investigations on this 'stemness' regulator in these deadly diseases
ZFX is a novel oncogene (show RAB1A ELISA Kits) promoting cell proliferation and inducing imatinib resistance via PI3K (show PIK3CA ELISA Kits)/Akt (show AKT1 ELISA Kits) signaling pathway
Zinc finger protein x-linked contributes to patient prognosis, and regulates cell proliferation and apoptosis in human laryngeal squamous cell carcinoma.
ZFX expression may have a role in poor prognosis of renal cell carcinoma patients
Nasopharyngeal carcinoma patients with high ZFX expression had lower 5-year overall survival rates, progression-free survival rates, loco-regional relapse-free survival rates and distant metastasis-free survival rates than those with low ZFX expression
ZFX transcripts were noted in all pre-compaction stage embryos and in female and male blastocysts; the expression of ZFX was significantly higher in female than in male blastocysts
This gene on the X chromosome is structurally similar to a related gene on the Y chromosome. It encodes a member of the krueppel C2H2-type zinc-finger protein family. The full-length protein contains an acidic transcriptional activation domain (AD), a nuclear localization sequence (NLS) and a DNA binding domain (DBD) consisting of 13 C2H2-type zinc fingers. Studies in mouse embryonic and adult hematopoietic stem cells showed that this gene was required as a transcriptional regulator for self-renewal of both stem cell types, but it was dispensable for growth and differentiation of their progeny. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, but the full-length nature of some variants has not been determined.
X-linked zinc finger protein
, zinc finger X-chromosomal protein
, zinc finger protein X-linked 5
, zinc finger protein X-linked 6
, zinc finger Y-chromosomal protein 1
, zinc finger protein 1, Y linked
, zinc finger protein X-linked
, Zinc finger X-chromosomal protein
, zinc finger protein ZFX