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May be involved in transcriptional regulation. Additionally we are shipping Zinc Finger Protein 131 Antibodies (83) and many more products for this protein.
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identify a novel substoichiometric interactor of the complex, transcription factor ZNF131, which recruits EMSY (show C11orf30 Proteins) to a large number of active, H3K4me3 marked promoters.
UHRF2 (show UHRF2 Proteins), a ubiquitin E3 ligase, acts as a small ubiquitin-like modifier (show SUMO1 Proteins) E3 ligase for zinc finger protein 131
these data suggest that ZNF131 inhibits estrogen signaling by acting as an ERalpha (show ESR1 Proteins)-co-repressor.
SUMOylation is a novel regulator of ZNF131 action in estrogen signaling and breast cancer cell proliferation.
The mechanism of Znf131 nuclear localization, is reported.
Interaction between ZNF131 and ERalpha (show ESR1 Proteins) interrupts or prevents ERalpha (show ESR1 Proteins) binding to the estrogen response element. ZNF131 also suppresses the expression of TFF1 (show TFF1 Proteins).
We also demonstrate that Kaiso (show ZBTB33 Proteins) inhibits Znf131 expression, raising the possibility that Kaiso (show ZBTB33 Proteins) and Znf131 act to fine-tune target gene expression. Together, our findings implicate Znf131 as a co-regulator of Kaiso (show ZBTB33 Proteins)-mediated biological processes.
Znf131 is critical for T cell development during double-negative to double-positive stage, with which significant cell expansion triggered by the pre-TCR signal is coupled.
Znf131 is a transcriptional activator, a less common function of POZ-ZF proteins, that is negatively regulated by its heterodimerization partner Kaiso (show ZBTB33 Proteins).
Results suggest that Znf131/ZNF131 plays a role during development and organogenesis as well as in the function of the adult central nervous system.
May be involved in transcriptional regulation. Plays a role during development and organogenesis as well as in the function of the adult central nervous system (By similarity).
zinc finger and BTB domain containing 35
, zinc finger protein 131 (clone pHZ-10)
, putative transcription factor ZNF131