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Zinc Finger Protein 163 Proteins (ZNF163)

ZNF163 encodes a nuclear zinc finger protein that functions as a transcriptional repressor. Additionally we are shipping Zinc Finger Protein 163 Antibodies (60) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ZNF163 14581 P70338
ZNF163 2672 Q99684
Rat ZNF163 ZNF163 24388 Q07120
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Top Zinc Finger Protein 163 Proteins at antibodies-online.com

Showing 5 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Dog His tag   1 mg Log in to see 56 to 66 Days
$3,175.33
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 9 to 11 Days
$229.85
Details

ZNF163 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,
,

More Proteins for Zinc Finger Protein 163 (ZNF163) Interaction Partners

Mouse (Murine) Zinc Finger Protein 163 (ZNF163) interaction partners

  1. these findings demonstrate a novel regulatory role of Gfi1 in the regulation of the Th1 (show HAND1 Proteins)-type immune response.

  2. GFI1 proteins recruit the chromatin-modifying protein LSD1 (show KDM1A Proteins), a member of the CoREST (show Rcor2 Proteins) repressive complex, to epigenetically silence the endothelial program in haemogenic endothelium and allow the emergence of blood cells

  3. GFI1 inhibits NLRP3 (show NLRP3 Proteins) inflammasome activation and IL-1beta (show IL1B Proteins) secretion in macrophages

  4. Gfi-1 is linked to the erythroid gene regulatory network by repressing Id2 expression.

  5. results, supported by evidence from mouse models, identify GFI1 and GFI1B (show GFI1B Proteins) as prominent medulloblastoma oncogenes and implicate 'enhancer hijacking' as an efficient mechanism driving oncogene (show RAB1A Proteins) activation in a childhood cancer

  6. Gfi1 and gfi1b (show GFI1B Proteins) repress rag transcription in plasmacytoid dendritic cells in vitro.

  7. Our data indicate that Gfi1 is required for hematopoietic precursors to withstand Notch1 (show NOTCH1 Proteins) activation and to maintain Notch1 (show NOTCH1 Proteins) dependent transcriptional programming to determine early T-lymphoid lineage identity.

  8. Data indicate that Gfi1 regulates the activation of type 2 innate lymphoid cells (ILC2 cells) cells during infection with Nippostrongylus brasiliensis.

  9. Gfi1 actively controls thymocyte IL-2 (show IL2 Proteins) production, thereby shaping thymic generation of Treg cells.

  10. Compromised IL-7Ralpha expression in TGF-beta-receptor-deficient T cells was associated with increased expression of the Il7ra transcriptional repressor, Gfi-1.

Human Zinc Finger Protein 163 (ZNF163) interaction partners

  1. Gfi1 gene expression is regulated by cytokines in activated T cells.

  2. miR-495 directly interacts with the Gfi1 3'UTR to regulate Gfi1 at a post-transcriptional level and the expression level of miR-495 is inversely correlated with the Gfi1 protein level in medulloblastoma specimens.

  3. Gfi1 acts as a transcriptional repressor by recruiting histone-modifying enzymes to promoters and enhancers of target genes. Mutations of the C-terminal zinc finger domain causes congenital neutropenia. It may be involved in leukemia and lymphoma. Review.

  4. During infection, the incoming HCMV rapidly downregulates the GFI1 mRNA and protein in both wild-type cells and in cells in which EZH2 (show EZH2 Proteins), NDY1/KDM2B (show KDM2B Proteins) or JARID2 (show JARID2 Proteins) were knocked down.

  5. Data shows that MYB regulates the expression of endogenous human GFI1.

  6. results, supported by evidence from mouse models, identify GFI1 and GFI1B (show GFI1B Proteins) as prominent medulloblastoma oncogenes and implicate 'enhancer hijacking' as an efficient mechanism driving oncogene (show RAB1A Proteins) activation in a childhood cancer

  7. Lymphoid progenitor cells from childhood acute lymphoblastic leukemia are functionally deficient and express high levels of the transcriptional repressor Gfi-1.

  8. GFI1 is repressed by p53 (show TP53 Proteins)

  9. the expression of Gfi-1 contributes to SOCS1 (show SOCS1 Proteins) silencing in AML (show RUNX1 Proteins) cells through epigenetic modification, and suppression of histone methyltransferase can provide new insight in AML (show RUNX1 Proteins) therapy.

  10. Studies indicate that Gfi1 recruits LSD1 (show KDM1A Proteins) to p53 (show TP53 Proteins) and dampens its activity by de-methylating p53 (show TP53 Proteins) at C-terminal lysines to prevent immediate apoptosis.

Zinc Finger Protein 163 (ZNF163) Protein Profile

Protein Summary

This gene encodes a nuclear zinc finger protein that functions as a transcriptional repressor. This protein plays a role in diverse developmental contexts, including hematopoiesis and oncogenesis. It functions as part of a complex along with other cofactors to control histone modifications that lead to silencing of the target gene promoters. Mutations in this gene cause autosomal dominant severe congenital neutropenia, and also dominant nonimmune chronic idiopathic neutropenia of adults, which are heterogeneous hematopoietic disorders that cause predispositions to leukemias and infections. Multiple alternatively spliced variants, encoding the same protein, have been identified for this gene.

Gene names and symbols associated with ZNF163

  • growth factor independent 1 (Gfi1)
  • growth factor independent 1 transcription repressor (GFI1)
  • growth factor independent 1 transcription repressor (Gfi1)
  • AW495828 protein
  • GFI-1 protein
  • GFI1A protein
  • Pal-1 protein
  • Pal1 protein
  • SCN2 protein
  • ZNF163 protein

Protein level used designations for ZNF163

growth factor independent protein 1 , zinc finger protein Gfi-1 , growth factor independence-1 , zinc finger protein 163 , growth factor independence 1 , Growth factor independent-1

GENE ID SPECIES
14581 Mus musculus
2672 Homo sapiens
490156 Canis lupus familiaris
24388 Rattus norvegicus
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