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C2H2-type zinc finger proteins, such as ZNF238, act on the molecular level as transcriptional activators or repressors and are involved in chromatin assembly (Becker et al., 1997 [PubMed 9568537]).[supplied by OMIM, Jan 2011].. Additionally we are shipping Zinc Finger Protein 238 Antibodies (22) and many more products for this protein.
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Human ZNF238 Protein expressed in Wheat germ - ABIN1326010
Mao, Ladd, Gad, Rastetter, Johnson, Marzbani, Childs, Lu, Dang, Broussard, Stanton, Hanash, Disis: Mining the pre-diagnostic antibody repertoire of TgMMTV-neu mice to identify autoantibodies useful for the early detection of human breast cancer. in Journal of translational medicine 2014
repression of the CR2/CD21 (show CR2 Proteins) promoter can occur through one of the E-box motifs via recruitment of RP58.
RP58 may act to favor neuronal differentiation and brain growth by coherently repressing multiple proneurogenic genes in a timely manner.
Findings indicate that ZNF238 is a novel brain tumor suppressor and its reactivation in tumors could open a novel anticancer strategy.
Disruption of RP58 expression alters the differentiation of immature neurons and impairs their migration and positioning within the mouse cerebral cortex.
RP58 represses Ngn2 (show NEUROG2 Proteins) transcription to regulate the Ngn2 (show NEUROG2 Proteins)-Rnd2 (show RND2 Proteins) pathway; Ngn2 (show NEUROG2 Proteins) knockdown rescued migration defects of the RP58(-/-) neurons.
Rp58 is essential for the growth and organization of the cerebellum and regulates the development of both GABAergic and glutamatergic neurons.
This study showed that Cre recombinase (show RAG1 Proteins) expression under the control of the RP58 gene promoter is a feasible tool for conditional gene switching in post-mitotic multipolar migrating young neurons in the developing cerebral cortex.
The authors report that a transcriptional factor, RP58, negatively regulates all four Id genes (Id1 (show ID1 Proteins)-Id4 (show ID4 Proteins)) in developing cerebral cortex.
Data show that inhibition of ZNF238 (RP58) expression in mouse GNPs decreases the expression of the neuronal differentiation markers MAP2 and NeuN (show RBFOX3 Proteins) and downregulates the expression of the cell cycle arrest protein p27 (show CDKN1B Proteins), a regulator of GNP differentiation.
The combined systems approach identified RP58 as an effector included in MyoD (show MYOD1 Proteins)-activated positive feedback and enabling progression of skeletal myogenesis by repressing expression of Id2 and Id3 (show ID3 Proteins), inhibitors of myogenesis.
These results suggest that RP58 plays a crucial role in neuronal proliferation, migration, and differentiation in the developing cerebral cortex.
Interestingly, co-transfection with simiRP58 (show ZBTB42 Proteins) and RP58 induced changes in the localization patterns of both proteins.
C2H2-type zinc finger proteins, such as ZNF238, act on the molecular level as transcriptional activators or repressors and are involved in chromatin assembly (Becker et al., 1997
BTB/POZ domain protein ZF238
, novel zinc finger domain containing protein
, zinc finger and BTB domain-containing protein 18
, zinc finger protein 238
, 58 kDa repressor protein
, transcriptional repressor RP58
, translin-associated zinc finger protein 1
, zinc finger protein C2H2-171