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Involved in transcriptional regulation. Additionally we are shipping Zinc Finger Protein 281 Antibodies (41) and many more products for this protein.
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High ZNF281 expression is associated with colon and breast cancer.
Zpf281 mediates Nanog autorepression through recruitment of the NuRD complex and hibits somatic cell reprogramming.
Data demonstrated that Zfp281 is required for Nanog (show NANOG Proteins) binding to its own promoter, suggesting that Nanog (show NANOG Proteins)-associated repressive complex(es) involving Zfp281 may fine-tune Nanog (show NANOG Proteins) expression for pluripotency of ESCs (show NR2E3 Proteins).
Zfp281 plays bifunctional roles in regulating gene expression within the network.
Involved in transcriptional regulation. Represses the transcription of a number of genes including gastrin and ornithine decarboxylase. Binds to the G-rich box in the enhancer region of these genes.
zinc finger protein 281
, GC-box-binding zinc finger protein 1
, ZNP-99 transcription factor
, transcription factor ZBP-99
, zinc finger DNA-binding protein 99