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Transcription factor that can both act as an activator or a repressor depending on the context. Additionally we are shipping and many more products for this protein.
Showing 10 out of 23 products:
Human Polyclonal ZNF521 Primary Antibody for EIA, IF - ABIN1449926
Warming, Liu, Suzuki, Akagi, Lindtner, Pavlakis, Jenkins, Copeland: Evi3, a common retroviral integration site in murine B-cell lymphoma, encodes an EBFAZ-related Krüppel-like zinc finger protein. in Blood 2003
two multi-zinc finger transcription cofactors named ZNF423 (show 104125 Antibodies) and ZNF521 have been characterised as potent inhibitors of EBF1 (show EBF1 Antibodies) and are emerging as potentially relevant contributors to the development of B-cell leukaemias
Data show that zinc finger protein 521 (ZNF521) can function as a repressor of osteoblastic differentiation of bone marrow mesenchymal stem cells (bmMSCs).
Newly discovered ZNF521-molecular partners of potentially relevant functional role, such as ZNF423 (show 104125 Antibodies), Spt16 (show SUPT16H Antibodies), Spt5 (show SUPT5H Antibodies), were discovered and validated by Western blotting.
Data strongly support the notion that ZNF521, through the recruitment of the NuRD complex, contributes to the clonogenic growth, migration and tumorigenicity of medulloblastoma cells.
Data show that ZNF521 can antagonize B-cell development and support the notion that it may contribute to conserve the multipotency of primitive lympho-myeloid progenitors by preventing or delaying their EBF1 (show EBF1 Antibodies)-driven commitment toward the B-cell lineage.
Zinc finger protein 521, a new player in bone formation.
EHZF is likely to play a relevant role in the control of human hematopoiesis and might be implicated in the development of hematopoietic malignancies.
A review of possible roles for ZNF521 in development, stem cell regulation and oncogenesis.
ZNF521 modulates erythroid cell differentiation through direct binding with GATA-1 (show GATA1 Antibodies).
Enhanced resistance of target cells to NK cell-mediated cytotoxicity was induced by enforced expression of EHZF in the cervical carcinoma cell line HeLa and in the B lymphoblastoid cell line IM9
Data show that zinc finger protein 521 (ZNF521) overexpression repressed osteoblastic differentiation of C3H10T1/2 cells.
Runx1 (show RUNX1 Antibodies)-dependent transcription factor gene Zfp521 is expressed in, and required for establishing molecular features that define, mechanoreceptors.
the data suggest that Zfp521 is a cell fate switch critical for BMP-induced osteoblast commitment and identify Zfp521 as the intrinsic repressor of Zfp423 and hence of adipocyte commitment during BMP-induced mesenchymal precursor differentiation.
the interplay between Zfp521 and Ebf1 (show EBF1 Antibodies) is identified as a novel rheostat for bone homeostasis.
Reduction of Zfp521 enhances adipogenic potential in vivo.
Zfp521 is a nuclear protein with 30 Kruppel-like zinc fingers mediating multiple protein-protein interactions, and regulates transcription in diverse tissues and organs.
we found the expression of Zfp521 declined with the neural differentiation of bone marrow mesenchymal stem cells, and miR (show MLXIP Antibodies)-9 could promote the neural differentiation via targeting Zfp521.
This study provides the first genetic evidence that Zfp521 is required downstream of PTHR1 (show PTH1R Antibodies) signaling to act on chondrocyte proliferation, differentiation, and cell death.
transition of ES cell differentiation from the epiblast state into neuroectodermal progenitors specifically depends on the cell-intrinsic expression and activator function of Zfp521
The balance and HDAC3 (show HDAC3 Antibodies)-dependent molecular interplay between Zfp521 and Runx2 (show RUNX2 Antibodies) contribute to the control of osteoblast differentiation, skeletal development, and bone homeostasis.
Transcription factor that can both act as an activator or a repressor depending on the context. Involved in BMP signaling and in the regulation of the immature compartment of the hematopoietic system. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved specification of B-cell lineage\; this interaction preventing EBF1 to bind DNA and activate target genes.
LYST-interacting protein 3
, early hematopoietic zinc finger protein
, ecotropic viral integration site 3 protein