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Transcriptional corepressor which does not bind directly to DNA and may regulate transcription through recruitment of histone deacetylases to gene promoters. Additionally we are shipping Zinc Finger Protein 703 Proteins (1) and many more products for this protein.
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Cow (Bovine) Polyclonal ZNF703 Primary Antibody for WB - ABIN2778360
Garcia, Pole, Chin, Teschendorff, Naderi, Ozdag, Vias, Kranjac, Subkhankulova, Paish, Ellis, Brenton, Edwards, Caldas: A 1 Mb minimal amplicon at 8p11-12 in breast cancer identifies new candidate oncogenes. in Oncogene 2005
Results show that ZNF703 overexpression is associated with adverse prognosis in head and neck squamous cell carcinomas, which might be a novel biomarker for this type of neoplasm.
ZNF703 was a target of SPRY4 (show SPRY4 Antibodies)-IT1 (show HAUS3 Antibodies).
Results show that ZNF703 expression is upregulated in colorectal cancer tissues (CRC (show CALR Antibodies)) and is significantly correlated with tumor size, pathological grading, and serosal and lymph node metastasis suggesting that it may act as an oncogene (show RAB1A Antibodies) in CRC (show CALR Antibodies).
The results showed that ZNF703 acts as a gastric cancer oncogene (show RAB1A Antibodies)
High expression of ZNF703 independent of amplification indicates worse prognosis in patients with luminal B breast cancer.
Data indicate that ZNF703 overexpression in MCF-7 breast cancer cells activated the Akt (show AKT1 Antibodies)/mTOR (show FRAP1 Antibodies) signaling pathway, downregulated ERalpha (show ESR1 Antibodies), and reduced the antitumor effect of tamoxifen.
The conserved domains are essential for proper subcellular localization and transcriptional repression of the NLZ1/ZNF703 protein.
ZNF703 expression results in the activation of stem cell-related gene expression leading to an increase in cancer stem cells.
These data strongly point to ZNF703 as a novel oncogene (show RAB1A Antibodies) in Luminal B breast cancer.
Data show that FGFR1 (show FGFR1 Antibodies) and DDHD2 (show DDHD2 Antibodies) at 8p12 cooperated functionally with MYC (show MYC Antibodies), whereas CCND1 (show CCND1 Antibodies) and ZNF703 cooperated with a dominant negative form of TP53 (show TP53 Antibodies).
Zeppo1 is a key regulator of breast cancer progression
Nlz1 is required for cilia formation in zebrafish embryogenesis.
nlz1 is expressed in the presumptive hindbrain and midbrain/hindbrain boundary. nlz2 (show ZNF503 Antibodies) is uniquely expressed more anteriorly, in the presumptive midbrain and diencephalon.
Nlz1/Znf703 acts as a repressor of transcription
identify misregulation of pax2 (show PAX2 Antibodies) in the developing eye of morphant fish, suggesting that Nlz1 and Nlz2 (show ZNF503 Antibodies) act upstream of the Pax2 (show PAX2 Antibodies) pathway in directing proper closure of the optic fissure
Transcriptional corepressor which does not bind directly to DNA and may regulate transcription through recruitment of histone deacetylases to gene promoters. Regulates cell adhesion, migration and proliferation. May be required for segmental gene expression during hindbrain development.
zinc finger elbow-related proline domain protein 1
, ES neuronal differentiation 2
, nocA related zinc finger 1
, nocA-like zinc finger protein 1
, nocA-related zinc finger protein 1