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ZNF750 encodes a protein with a nuclear localization site and a C2H2 zinc finger domain. Additionally we are shipping Zinc Finger Protein 750 Antibodies (26) and many more products for this protein.
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Human ZNF750 Protein expressed in Escherichia coli (E. coli) - ABIN2736118
Boxer, Barajas, Tao, Zhang, Khavari: ZNF750 interacts with KLF4 and RCOR1, KDM1A, and CTBP1/2 chromatin regulators to repress epidermal progenitor genes and induce differentiation genes. in Genes & development 2014
BENI expression is regulated by activin-like signaling, and that this regulation is crucial for Xbra expression and convergent extension during gastrulation.
Suggest no connection of ZNF750 variants with psoriasis or its subphenotypes.
ZNF750 thus controls differentiation in concert with RCOR1 (show RCOR1 Proteins) and CTBP1 (show CTBP1 Proteins)/2 by acting with either KDM1A (show KDM1A Proteins) to repress progenitor genes or KLF4 (show KLF4 Proteins) to induce differentiation genes.
ZNF750 was specifically expressed in the epidermal suprabasal layers and its expression was augmented during differentiation, both in human skin and in-vitro, peaking in the granular layer.
ZNF750 directly links a tissue-specifying factor, p63 (show RPE65 Proteins), to an effector of terminal differentiation, KLF4 (show KLF4 Proteins).
Two haplotypes of ZNF750 and rare 5' regulatory variants of ZNF750 were found to be associated with psoriasis.
ZNF750 mutations could contribute to psoriasis susceptibility.
This gene encodes a protein with a nuclear localization site and a C2H2 zinc finger domain. Mutations in this gene have been associated with seborrhea-like dermatitis with psoriasiform elements.
, zinc finger protein 750
, superficial protein 1
, Protein ZNF750
, brachyury expression nuclear inhibitor