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May link EHMT1 and EHMT2 histone methyltransferases to the CTBP corepressor machinery.
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Human Polyclonal ZNF803 Primary Antibody for WB - ABIN375091
Rathert, Dhayalan, Murakami, Zhang, Tamas, Jurkowska, Komatsu, Shinkai, Cheng, Jeltsch: Protein lysine methyltransferase G9a acts on non-histone targets. in Nature chemical biology 2008
Human Polyclonal ZNF803 Primary Antibody for EIA, WB - ABIN783351
Matsumoto, Ishii, Yoshida, Shiosaka, Wanaka, Tohyama: Molecular cloning and distinct developmental expression pattern of spliced forms of a novel zinc finger gene wiz in the mouse cerebellum. in Brain research. Molecular brain research 1999
Disrupting the association of G9a (show EHMT2 Antibodies)-GLP (show RCBTB1 Antibodies) with chromatin by depleting WIZ resulted in altered gene expression and protein-protein interactions that were distinguishable from that of small molecule-based inhibition of G9a (show EHMT2 Antibodies)/GLP (show RCBTB1 Antibodies)
Data indicate zinc finger proteins ZNF644 (show ZNF644 Antibodies) and WIZ as two core subunits in the histone-lysine N-methyltransferase G9a (show EHMT2 Antibodies)/GLP (show RCBTB1 Antibodies) complex, and interact with the transcription activation domain of G9a (show EHMT2 Antibodies) and GLP (show RCBTB1 Antibodies).
Wiz plays a major role in G9a (show EHMT2 Antibodies)/GLP (show GOLGA6A Antibodies) heterodimer formation in cultured stem cells.
May link EHMT1 and EHMT2 histone methyltransferases to the CTBP corepressor machinery. May be involved in EHMT1-EHMT2 heterodimer formation and stabilization (By similarity).
, WIZ zinc finger
, widely-interspaced zinc finger motifs
, widely-interspaced zinc finger-containing protein
, zinc finger protein 803