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May be a transcription factor that may be involved in hematopoiesis, oncogenesis, and immune responses (By similarity). Additionally we are shipping ZBTB20 Antibodies (14) and many more products for this protein.
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3q13.31 microdeletion-based dosage imbalance of ZBTB20 linked to a range of neurodevelopmental, cognitive and psychiatric disorders, likely mediated by dysregulation of multiple ZBTB20 target genes.
Major depressive disorder is associated with significant hypermethylation within the coding region of ZBTB20.
important role for ZBTB20 in controlling NSCLC development
Missense mutations in ZBTB20 underlie Primrose syndrome.
This study disclosed Zbtb20-mediated transcriptional repressor mechanism may be involved in development of the human archicortex.
Polymorphism in ZBTB20 gene is associated with gastric cancer.
We identified new susceptibility loci for non-cardia gastric cancer at 3q13.31: rs9841504 in ZBTB20
ZBTB20 mRNA & protein expression were elevated significantly in HCC (show FAM126A Proteins) tissues compared with the paired non-tumor tissues & normal liver. HCC (show FAM126A Proteins) recurrence or metastasis increased & disease-free survival decreased with high ZBTB20 expression.
Misexpression of Zbtb20 in transgenic mice co (show CA1 Proteins)nverts the normal cytoarchitectonic organization of the subiculum, postsubiculum, and granular retrosplenial cortex to a CA1-like stratum pyramidale.
ZBTB20, an important transcriptional factor in pituitary development, is mainly responsible for the terminal differentiation of prolactin (show PRL Proteins)-secreting cells, thereby regulating the secretion of the pituitary hormones
Data indicate that transcription factor ZBTB20 is essential for lactotrope lineage specification.
Zbtb20 regulates astrocyte specification in the mouse neocortex.
Mutation of the core sequence in this site fully abolished its binding to ZBTB20 in vitro, as well as the repression of AFP (show AFP Proteins) promoter activity by ZBTB20.
ZBTB20 regulates nociception and pain sensation by modulating TRPV1 (show TRPV1 Proteins), TRPA1 (show TRPA1 Proteins) and TRPM8 (show TRPM8 Proteins) expression in nociceptive sensory neurons.
Specific deficiency of Plzf (show ZBTB16 Proteins) paralog, Zbtb20, in Sertoli cells does not affect spermatogenesis and fertility in mice
Zbtb20 regulates the terminal differentiation of hypertrophic chondrocytes via repression of Sox9 (show SOX9 Proteins).
ZBTB20 is involved in liver regeneration after partial hepatectomy in mouse.
ZBTB20 plays a role in promoting survival, and hence antibody production in plasma cells.
The BTB-ZF transcription factor Zbtb20 is driven by Irf4 (show IRF4 Proteins) to promote plasma cell differentiation and longevity.
May be a transcription factor that may be involved in hematopoiesis, oncogenesis, and immune responses (By similarity). Binds to DNA.
BTB/POZ zinc finger protein DPZF
, dendritic cell-derived BTB/POZ zinc finger
, dendritic-derived BTB/POZ zinc finger protein
, zinc finger and BTB domain-containing protein 20
, zinc finger protein 288
, BTB/POZ domain zinc finger factor HOF
, POZ/zinc finger transcription factor ODA-8