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acts as a transcriptional repressor\; may play a role in osteoclastogenesis [RGD, Feb 2006].. Additionally we are shipping ZBTB7A Kits (10) and ZBTB7A Proteins (4) and many more products for this protein.
Showing 10 out of 106 products:
Human Polyclonal ZBTB7A Primary Antibody for EIA, IF - ABIN783361
Filion, Zhenilo, Salozhin, Yamada, Prokhortchouk, Defossez: A family of human zinc finger proteins that bind methylated DNA and repress transcription. in Molecular and cellular biology 2005
Show all 4 references for ABIN783361
Human Polyclonal ZBTB7A Primary Antibody for IP, IHC - ABIN152180
Aggarwal, Hunter, Aggarwal, Silva, Davey, Murphy, Agrawal: Expression of leukemia/lymphoma-related factor (LRF/POKEMON) in human breast carcinoma and other cancers. in Experimental and molecular pathology 2010
Show all 3 references for ABIN152180
Mouse (Murine) Polyclonal ZBTB7A Primary Antibody for WB - ABIN2779953
He, He, Dave, Zhang, Hua, Nicolas, Xu, Roe, Kappes: The zinc finger transcription factor Th-POK regulates CD4 versus CD8 T-cell lineage commitment. in Nature 2005
Human Polyclonal ZBTB7A Primary Antibody for IF (p), IHC (p) - ABIN729448
Zhao, Yao, Li, An, Chen, Sun, Kang, Wang, Hu: Pokemon enhances proliferation, cell cycle progression and anti-apoptosis activity of colorectal cancer independently of p14(ARF)-MDM2-p53 pathway. in Medical oncology (Northwood, London, England) 2014
Cow (Bovine) Polyclonal ZBTB7A Primary Antibody for WB - ABIN2776524
Laudes, Christodoulides, Sewter, Rochford, Considine, Sethi, Vidal-Puig, ORahilly: Role of the POZ zinc finger transcription factor FBI-1 in human and murine adipogenesis. in The Journal of biological chemistry 2004
Chicken Polyclonal ZBTB7A Primary Antibody for WB - ABIN2780246
Yang, Zhou, Zhu, Zhang, Yang, Xu, Huang: Cloning and functional analysis of 5'-upstream region of the Pokemon gene. in The FEBS journal 2008
Human Polyclonal ZBTB7A Primary Antibody for IHC (p), WB - ABIN658129
Qu, Qu, Chen, Zhang, Liu, Liu: ZBTB7 overexpression contributes to malignancy in breast cancer. in Cancer investigation 2010
Pokemon was found to enhance the migration and invasion of hepatocellular carcinoma by increasing MEF2D (show MEF2D Antibodies) expression
Pokemon was significantly downregulated in OSCC.
ZBTB7A directly binds to the promoter and transcriptionally represses the expression of MCAM (show MCAM Antibodies), establishing ZBTB7A as a bona fide transcriptional repressor of MCAM (show MCAM Antibodies)
MEF2D (show MEF2D Antibodies) was also found to increase the transcription of Pokemon by binding myocyte enhancer factor 2 (MEF2 (show MEF2A Antibodies)) sites within its promoter region, that can promote Hepatocellular carcinoma invasion
this study found that LRF/ZBTB7A transcription factor occupies fetal gamma-globin (show HBG1 Antibodies) genes and maintains the nucleosome density necessary for gamma-globin (show HBG1 Antibodies) gene silencing in adults, and that LRF confers its repressive activity through a NuRD repressor complex independent of the fetal globin repressor BCL11A (show BCL11A Antibodies).
p38beta (show MAPK11 Antibodies) is a novel regulatory target of the transcription factor Pokemon and positively regulated by Pokemon in hepatic cells.
Taken together, all these data suggest that Pokemon is a new partner of Smad4 (show SMAD4 Antibodies) and plays a negative role in TGF-beta (show TGFB1 Antibodies) pathway.
Pokemon prevents anoikis through the suppression of Bim (show BCL2L11 Antibodies) expression, which facilitates tumor cell invasion and metastasis.
Pokemon enhanced the oncogenesis of colorectal cancer by promoting cell proliferation, cell cycle progression and anti-apoptosis activity.
our findings suggest that TGF-b1 may inhibit the expression of Pokemon, b-catenin, and E-cadherin (show CDH1 Antibodies). The high expression of TGF-b1 leads to an increase in the phenotype and apical-base polarity of epithelial cells
This study demonstrated an unexpected transcription-independent function for LRF in the classical non-homologous end joining pathway of double-strand break repair.
LRF short hairpin RNA suppressed the expression of LRF protein in a glioma cell line compared to the negative control vector-transfected glioma cells. LRF knockdown also reduced cell viability and enhanced cisplatin-induced apoptosis in glioma cells.
Data indicate that transcription factors Thpok (show ZBTB7B Antibodies) and LRF redundantly maintain CD4 (show CD4 Antibodies)+ lineage integrity.
Findings demonstrate that Pokemon suppresses Sprouty1 expression through a miR (show MLXIP Antibodies)-21-mediated mechanism, affecting the growth and proliferation of liver cancer cells.
Data show that Notch1 (show NOTCH1 Antibodies)/Dll4 (show DLL4 Antibodies)-mediated T-cell instructive signals to long-term HSCs (LT-HSCs) are suppressed by Lrf expression in the bone marrow microenvironment.
These results support a critical role for LRF in transcriptional control of differentiation in oligodendrocyte lineage cells during developmental myelination in the CNS.
T cells lacking Thpok (show ZBTB7B Antibodies), which only displayed LRF-dependent functions, contributed to multiple effector responses, both in vitro and in vivo, with the notable exception of Th2 cell responses that control extracellular parasites
study shows that LRF plays stage-specific distinct roles in osteoclast differentiation, exemplifying the delicate transcriptional regulation at work in lineage commitment
Data demonstrate that the transcription factor leukemia/lymphoma-related factor (LRF) forms an obligate dimer in B cells and regulates mature B cell lineage fate and humoral immune responses via distinctive mechanisms.
analysis of the miRNA-mediated interaction between leukemia/lymphoma-related factor (LRF) and alternative splicing factor/splicing factor (show SLU7 Antibodies) 2 (ASF/SF2 (show SRSF1 Antibodies)) affects cell senescence and apoptosis
acts as a transcriptional repressor\; may play a role in osteoclastogenesis
zinc finger and BTB domain containing 7A
, similar to zinc finger and BTB domain containing 36
, HIV-1 1st-binding protein 1
, HIV-1 inducer of short transcripts binding protein
, POK erythroid myeloid ontogenic factor
, POZ and Krueppel erythroid myeloid ontogenic factor
, TTF-I-interacting peptide 21
, factor binding IST protein 1
, factor that binds to inducer of short transcripts protein 1
, leukemia/lymphoma-related factor
, lymphoma related factor
, zinc finger and BTB domain containing 7A, HIV-1 inducer of short transcripts binding protein
, zinc finger and BTB domain-containing protein 7A
, zinc finger protein 857A
, leukemia/lymphoma related factor
, osteoclast-derived zinc finger protein
, leukemia/lymphoma related factor cLRF