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Zinc Finger and BTB Domain Containing 7B Proteins (ZBTB7B)

ZBTB7B encodes a zinc finger-containing transcription factor that acts as a key regulator of lineage commitment of immature T-cell precursors. Additionally we are shipping Zinc Finger and BTB Domain Containing 7B Antibodies (85) and Zinc Finger and BTB Domain Containing 7B Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ZBTB7B 51043 O15156
Rat ZBTB7B ZBTB7B 295248  
Mouse ZBTB7B ZBTB7B 22724 Q64321
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Top Zinc Finger and BTB Domain Containing 7B Proteins at antibodies-online.com

Showing 2 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

ZBTB7B Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,

More Proteins for Zinc Finger and BTB Domain Containing 7B (ZBTB7B) Interaction Partners

Human Zinc Finger and BTB Domain Containing 7B (ZBTB7B) interaction partners

  1. a novel pathway by which TIP60 (show KAT5 Proteins) and ThPOK synergistically suppresses Eomes (show EOMES Proteins) function and IFNgamma production, which could contribute to the regulation of inflammation.

  2. ThPOK may be considered a central regulator of the earliest events in the immune system during colorectal cancer development, decreasing the immune response against cancer cells.

  3. The distal regulatory element (DRE (show SUFUH Proteins)) in the Thpok gene also functions as a transcriptional enhancer, with DNA sequences specifically responsible for thymic enhancer activity.

  4. ThPOK transgene stably represses CD8 (show CD8A Proteins) gene expression through the deacetylation of Cd8 (show CD8A Proteins) loci in CD4 (show CD4 Proteins) cell lineage commitment.

  5. The p65 subunit of NF-kappaB inhibits COL1A1 gene transcription in human dermal and scleroderma fibroblasts through its recruitment on promoter by protein interaction with transcriptional activators (c-Krox, Sp1, and Sp3).

  6. impairment of Lck (show LCK Proteins)-mediated CD4 (show CD4 Proteins) coreceptor signaling by Nef is an important in vivo mechanism of HIV-1 pathogenesis

  7. Thymoma neoplastic epithelial cells can induce Th-POK expression in T-cell subsets similarly to the normal thymic epithelial cells. In addition, there was no significant difference in Runx3 (show RUNX3 Proteins) expression in T-cell subsets between normal thymi and thymomas.

  8. These data suggest that the regulation of COL1A1 gene transcription in human dermal fibroblasts involves a complex machinery that implicates at least three transcription proteins, hc-Krox, Sp1, and Sp3.

  9. Chondroitin sulphate and its derived hydrolytic fragments (CSf (show CSF2 Proteins)) repress COL1A1 (show COL1A1 Proteins) gene transcription through a -112/-61 bp sequence upstream the start site of transcription and imply hc-Krox and Sp1 (show PSG1 Proteins) transcription factors.

  10. Runx and ThPOK role in mechanisms of lineage-specific gene regulation in the process of T-cell commitments[review]

Mouse (Murine) Zinc Finger and BTB Domain Containing 7B (ZBTB7B) interaction partners

  1. Runx3 (show RUNX3 Proteins) is crucial for the phenotypic and functional changes observed in ThPok-deficient invariant natural killer T cells.

  2. present evidence that ectopic ThPOK expression gives rise to a preleukemic and self-perpetuating DN4 lymphoma precursor population

  3. Data indicate that transcription factors Thpok and LRF (show ZBTB7A Proteins) redundantly maintain CD4 (show CD4 Proteins)+ lineage integrity.

  4. induction of SOCS (show CISH Proteins)-encoding genes is the main mechanism by which ThPOK imposes the CD4 (show CD4 Proteins)(+) lineage fate in the thymus

  5. The role of TCF-1 (show HNF1A Proteins) and LEF-1 (show LEF1 Proteins) in the CD4 (show CD4 Proteins)-versus-CD8 (show CD8A Proteins) lineage 'choice' was mediated in part by direct positive regulation of the transcription factor Th-POK

  6. These findings imply that long-lasting T-cell receptor signals are needed to establish stable Thpok expression activity to commit to helper T-cell fate.

  7. Gata3 (show GATA3 Proteins) promotes Cd4 (show CD4 Proteins) expression in Thpok-deficient thymocytes.

  8. Data indicate that Valpha14 invariant natural killer T (Valpha14i NKT (show CTSL1 Proteins)) cells from Th-POK-mutant helper deficient (hd/hd (show HTT Proteins)) mice have increased transcripts of genes normally expressed by Th17 and NKT17 cells.

  9. ZBTB7B is a critical factor genetically predetermining the balance of effector subsets within the NKT (show CTSL1 Proteins) cell population.

  10. Th-POK and Runx3 (show RUNX3 Proteins) transcription factors are reciprocally involved in the control of G1-phase progression, on which they exert their functions dependently.

Zinc Finger and BTB Domain Containing 7B (ZBTB7B) Protein Profile

Protein Summary

This gene encodes a zinc finger-containing transcription factor that acts as a key regulator of lineage commitment of immature T-cell precursors. It is necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. It also functions as a transcriptional repressor of type I collagen genes. Alternatively spliced transcript variants have been found for this gene.

Gene names and symbols associated with ZBTB7B

  • zinc finger and BTB domain containing 7B (ZBTB7B)
  • kruppel-related zinc finger protein hcKrox (zbtb7b)
  • zinc finger and BTB domain containing 7B (Zbtb7b)
  • zinc finger protein 317 (Zfp317)
  • 4932416G03 protein
  • c-Krox protein
  • D230022C05Rik protein
  • hcKROX protein
  • KRAB9 protein
  • MGC130914 protein
  • mszf40 protein
  • Thpok protein
  • zbtb7b protein
  • ZBTB15 protein
  • ZFP-67 protein
  • Zfp67 protein
  • Zfp75 protein
  • ZNF857B protein

Protein level used designations for ZBTB7B

zinc finger and BTB domain containing 7B , kruppel-related zinc finger protein hcKrox , T-helper-inducing POZ/Krueppel-like factor , krueppel-related zinc finger protein cKrox , zinc finger and BTB domain containing 15 , zinc finger and BTB domain-containing protein 7B , zinc finger protein 67 homolog , zinc finger protein 857B , zinc finger protein Th-POK , zinc finger protein 67 , T helper-inducing POZ/Krueppel factor , Vzinc finger and BTB domain containing 7B , zfp-67 , zinc finger protein 75

GENE ID SPECIES
457353 Pan troglodytes
779199 Xenopus laevis
51043 Homo sapiens
295248 Rattus norvegicus
22724 Mus musculus
244713 Mus musculus
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