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anti-Zinc Metalloproteinase, Ste24 (Zmpste24) Antibodies

Zmpste24 encodes a member of the peptidase M48A family. Additionally we are shipping Zinc Metalloproteinase, Ste24 Proteins (7) and Zinc Metalloproteinase, Ste24 Kits (2) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
Zmpste24 10269 O75844
Zmpste24 313564  
Zmpste24 230709 Q80W54
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Top anti-Zinc Metalloproteinase, Ste24 Antibodies at antibodies-online.com

Showing 10 out of 90 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-ZMPSTE24 Antibody Titration: 0.2-1 ug/mlPositive Control: Jurkat cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IHC (p), WB The anti-ZMPSTE24 Pab (ABIN389049) is used in Western blot to detect ZMPSTE24 in T-47D cell lysate. Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 10 to 12 Days
$427.35
Details
Human Rabbit Un-conjugated IHC (p), WB The anti-ZMPSTE24 Pab (ABIN389048) is used in Western blot to detect ZMPSTE24 in mouse cerebellum tissue lysate. Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Goat Un-conjugated ELISA, WB ABIN185713 (0.5µg/ml) staining of Human Skin lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 4 to 5 Days
$318.20
Details
Human Rabbit Un-conjugated WB ZMPSTE24 Antibody (C-term) (ABIN1882012) western blot analysis in HepG2 cell line lysates (35 µg/lane). This demonstrates the ZMPSTE24 antibody detected the ZMPSTE24 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Goat Un-conjugated WB 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated ELISA, WB 50 μg Log in to see 2 to 3 Days
$433.13
Details

Zmpste24 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human ,
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, , , , , , , ,
Rat (Rattus)



Mouse (Murine)



Top referenced anti-Zinc Metalloproteinase, Ste24 Antibodies

  1. Human Polyclonal Zmpste24 Primary Antibody for WB - ABIN1882012 : Fontaine-Bisson, Alessi, Saut, Fumeron, Marre, Dutour, Badens, Levy, Tichet, Juhan-Vague, Trégouët, Balkau, Morange: Polymorphisms of the lamina maturation pathway and their association with the metabolic syndrome: the DESIR prospective study. in Journal of molecular medicine (Berlin, Germany) 2010 (PubMed)
    Show all 3 references for ABIN1882012

  2. Human Polyclonal Zmpste24 Primary Antibody for IHC (p), WB - ABIN389048 : Kumagai, Kawamura, Yanagisawa, Komano: Identification of a human cDNA encoding a novel protein structurally related to the yeast membrane-associated metalloprotease, Ste24p. in Biochimica et biophysica acta 1999 (PubMed)
    Show all 3 references for ABIN389048

  3. Human Polyclonal Zmpste24 Primary Antibody for IHC (p), WB - ABIN389049 : Moulson, Go, Gardner, van der Wal, Smitt, van Hagen, Miner: Homozygous and compound heterozygous mutations in ZMPSTE24 cause the laminopathy restrictive dermopathy. in The Journal of investigative dermatology 2005 (PubMed)
    Show all 2 references for ABIN389049

  4. Human Polyclonal Zmpste24 Primary Antibody for EIA, IHC (p) - ABIN357708 : Freije, Blay, Pendás, Cadiñanos, Crespo, López-Otín: Identification and chromosomal location of two human genes encoding enzymes potentially involved in proteolytic maturation of farnesylated proteins. in Genomics 1999 (PubMed)
    Show all 2 references for ABIN357708

  5. Human Polyclonal Zmpste24 Primary Antibody for EIA, IHC (p) - ABIN357707 : Corrigan, Kuszczak, Rusinol, Thewke, Hrycyna, Michaelis, Sinensky: Prelamin A endoproteolytic processing in vitro by recombinant Zmpste24. in The Biochemical journal 2005 (PubMed)

  6. Human Polyclonal Zmpste24 Primary Antibody for WB - ABIN374738 : Fong, Frost, Meta, Qiao, Yang, Coffinier, Young: A protein farnesyltransferase inhibitor ameliorates disease in a mouse model of progeria. in Science (New York, N.Y.) 2006 (PubMed)

More Antibodies against Zinc Metalloproteinase, Ste24 Interaction Partners

Human Zinc Metalloproteinase, Ste24 (Zmpste24) interaction partners

  1. ZMPSTE24 downregulation is a major contributor in VSMC dysfunctions resulting from LMNA (show LMNA Antibodies) mutations or PI treatments that could translate in early atherosclerosis at the clinical level.

  2. Here, we report on a familial c.50delA (p.Lys17Serfs*21) mutation of the ZMPSTE24 gene, causing RD in two siblings.

  3. complete loss-of-function of ZMPSTE24 leads to RD, whereas other less severe phenotypes are associated with at least one haploinsufficient allele.

  4. miR (show MLXIP Antibodies)-141-3p, which is overexpressed during senescence as a result of epigenetic regulation, is able to decrease ZMPSTE24 expression levels, and leads to an upregulation of prelamin A in human mesenchymal stem cells.

  5. Laminopathy-associated mutations predicted to reduce ZMPSTE24 activity map to the zinc metalloprotease (show ADAM8 Antibodies) peptide-binding site and to the bottom of the chamber.

  6. Characterization of disease causing mutations in the ZMPSTE24 gene, residual proteolytic activity correlates with disease severity.

  7. A report of a novel and a previously reported homozygous null mutation in ZMPSTE24 in two newborns with restrictive dermopathy.

  8. Three of 87 patients with metabolic syndrome carry a heterozygous mutation in LMNA (show LMNA Antibodies) or in ZMPSTE24.

  9. In patients with mandibuloacral dysplasia due to ZMPSTE24 mutations, the onset of disease manifestations such as thin skin and micrognathia occurs as early as 5 months of age.

  10. Data show that mandibuloacral dysplasia associated with ZMPSTE24 mutations has a more severe phenotype than that associated with lamin A (show LMNA Antibodies) mutations.

Mouse (Murine) Zinc Metalloproteinase, Ste24 (Zmpste24) interaction partners

  1. we identified the abnormal lamin A (show LMNA Antibodies) (prelamin A), accompanied by a down-regulation of a lamin A (show LMNA Antibodies) processing enzyme (Zmpste24) in the kidney of the GMF (show GMFB Antibodies) transgenic mice

  2. In Zmpste24(-/-) mice, histone H4 (show HIST1H4H Antibodies) was hypoacetylated at a lysine 16 residue (H4K16), and this defect was attributed to the reduced association of a histone acetyltransferase (show HAT Antibodies), Mof (show KAT8 Antibodies), to the nuclear matrix.

  3. Nuclear envelope alterations generate an aging-like epigenetic pattern in mice deficient in Zmpste24 metalloprotease (show ADAMTS7 Antibodies)

  4. Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase-deficient mice.

  5. Zmpste24 has a role in processing of prelamin A and lack of Zmpste24 results in a brittle bone phenotype

  6. the progeria-like phenotypes caused by the lack of Zmpste24 in knockout mice is eliminated by heterozygosity for Lmna (show LMNA Antibodies)

  7. Lack of functional Zmpste24, a metalloproteinase responsible for the maturation of prelamin A, also results in progeroid phenotypes in mice

  8. Zmpste24 deficiency elicits a stress signalling pathway that is evidenced by a marked upregulation of p53 (show TP53 Antibodies) target genes, and accompanied by a senescence phenotype at the cellular level and accelerated ageing at the organismal level

  9. darunavir does not inhibit the biochemical activity of ZMPSTE24, nor does it lead to an accumulation of farnesyl-prelamin A in cells.

  10. Zmpste24-null mice show accelerated aging and exhibit an extensive basal activation of autophagy.

Zinc Metalloproteinase, Ste24 (Zmpste24) Antigen Profile

Protein Summary

This gene encodes a member of the peptidase M48A family. The encoded protein is a zinc metalloproteinase involved in the two step post-translational proteolytic cleavage of carboxy terminal residues of farnesylated prelamin A to form mature lamin A. Mutations in this gene have been associated with mandibuloacral dysplasia and restrictive dermopathy.

Gene names and symbols associated with Zmpste24

  • zinc metallopeptidase (STE24 homolog, S. cerevisiae) (ZMPSTE24) antibody
  • zinc metallopeptidase STE24 (zmpste24) antibody
  • zinc metallopeptidase STE24 homolog (S. cerevisiae) (ZMPSTE24) antibody
  • CAAX prenyl protease (zmpste24) antibody
  • zinc metallopeptidase (STE24 homolog, S. cerevisiae) (zmpste24) antibody
  • peptidase family M48 family protein (ATSTE24) antibody
  • zinc metallopeptidase STE24 (ZMPSTE24) antibody
  • zinc metallopeptidase STE24 (Zmpste24) antibody
  • zinc metallopeptidase, STE24 (Zmpste24) antibody
  • zinc metallopeptidase, STE24 homolog (zmpste24) antibody
  • A530043O15Rik antibody
  • D030046F19 antibody
  • DDBDRAFT_0189115 antibody
  • DDBDRAFT_0237846 antibody
  • DDB_0189115 antibody
  • DDB_0237846 antibody
  • F2N1.21 antibody
  • F2N1_21 antibody
  • Face-1 antibody
  • FACE1 antibody
  • fi45a02 antibody
  • HGPS antibody
  • MADB antibody
  • PRO1 antibody
  • STE24 antibody
  • Ste24p antibody
  • wu:fi45a02 antibody
  • zgc:55655 antibody

Protein level used designations for Zmpste24

zinc metallopeptidase (STE24 homolog, S. cerevisiae) , zinc metallopeptidase (STE24 homolog) , zinc metallopeptidase STE24 homolog , zinc metalloproteinase STE24 homolog , CAAX prenyl protease 1 homolog , STE24 endopeptidase , zinc metalloproteinase , zinc metallopeptidase STE24 , CAAX prenyl protease 1 homolog-like , farnesylated proteins-converting enzyme 1 , prenyl protein-specific endoprotease 1 , zinc metalloproteinase Ste24 homolog , zinc metallopeptidase, STE24 homolog , zinc metalloproteinase, STE24 homolog , farnesylated-proteins converting enzyme 1 , zinc metalloproteinase (STE24 homolog, yeast)

GENE ID SPECIES
419572 Gallus gallus
447784 Xenopus laevis
456790 Pan troglodytes
482460 Canis lupus familiaris
550009 Xenopus (Silurana) tropicalis
693765 Macaca mulatta
8627861 Dictyostelium discoideum AX4
100032108 Monodelphis domestica
100339077 Oryctolagus cuniculus
100404786 Callithrix jacchus
100445390 Pongo abelii
100475834 Ailuropoda melanoleuca
100557771 Anolis carolinensis
100580430 Nomascus leucogenys
828209 Arabidopsis thaliana
538104 Bos taurus
10269 Homo sapiens
313564 Rattus norvegicus
230709 Mus musculus
334380 Danio rerio
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