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anti-alpha Hemoglobin Stabilizing Protein (aHSP) Antibodies

Act as a chaperone to prevent the harmful aggregation of alpha-hemoglobin during normal erythroid cell development. Additionally we are shipping aHSP Proteins (17) and aHSP Kits (14) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
aHSP 51327 Q9NZD4
aHSP 170812 Q9CY02
aHSP 293522  
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Top anti-aHSP Antibodies at antibodies-online.com

Showing 10 out of 38 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Mouse Rabbit Un-conjugated FM, IHC (fp), ELISA, WB Immunohistochemistry of Rabbit anti-AHSP antibody. Tissue: A. Normal bone marrow, H&E. B. CD235a stains both nucleated EPs and mature, anucleate RBCs. C. AHSP stains nucleated EPs, but not mature, anucleate RBCs. D. CD71 stains nucleated EPs, but not mature, anucleate RBCs. Fixation: acetic acid-zinc-formalin and formalin fixation, embedded in paraffin Antigen retrieval: TRIS-EDTA pH9.0 Primary antibody: AHSP antibody at 1:8,000 for overnight at 4°C Secondary antibody: anti-rabbit secondary at (1:10,000 for 45 min at RT) Localization: Anti-AHSP is cytoplasmic Staining: AHSP antibody as precipitated brown signal with a purple nuclear counterstain using Bond-max™ – fully automated for IHC. 25 μL Log in to see 2 to 3 Days
$135.00
Details
Human Mouse Un-conjugated ELISA, WB Detection limit for recombinant GST tagged ERAF is 0.03 ng/ml as a capture antibody. Western Blot detection against Immunogen (36.96 KDa) . 100 μg Log in to see 9 Days
$430.00
Details
Human Rabbit Un-conjugated IHC, ELISA, WB 100 μL Log in to see 8 to 10 Days
$610.50
Details
Mouse Rabbit Un-conjugated ICC, IHC (fro), IHC (p), ELISA, WB 100 μg Log in to see 11 to 13 Days
$356.40
Details
Human Rabbit Un-conjugated ICC, IHC (fro), IHC (p), ELISA, WB 100 μg Log in to see 11 to 13 Days
$347.60
Details
Rat Rabbit Un-conjugated ICC, IHC (fro), IHC (p), ELISA, WB 100 μg Log in to see 9 to 11 Days
$376.20
Details
Human Mouse Un-conjugated ELISA, WB Western Blot analysis of ERAF expression in transfected 293T cell line by ERAF monoclonal antibody (M32), clone 2E4.Lane 1: ERAF transfected lysate(11.8 KDa).Lane 2: Non-transfected lysate. Western Blot detection against Immunogen (38.2 KDa) . 100 μg Log in to see 9 Days
$430.00
Details
Human Mouse Un-conjugated ELISA, WB Western Blot analysis of ERAF expression in transfected 293T cell line by ERAF polyclonal antibody (A01).Lane1:ERAF transfected lysate(11.84 KDa).Lane2:Non-transfected lysate. Western Blot detection against Immunogen (37.33 KDa) . 50 μL Log in to see 9 Days
$298.57
Details
Human Rabbit Biotin ELISA   100 μg Log in to see 8 to 10 Days
$537.17
Details
Human Rabbit FITC ELISA   100 μg Log in to see 8 to 10 Days
$551.83
Details

aHSP Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human , ,
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Mouse (Murine)


Rat (Rattus) ,


Top referenced anti-aHSP Antibodies

  1. Mouse (Murine) Polyclonal aHSP Primary Antibody for FM, IHC (fp) - ABIN1043696 : Nasimuzzaman, Khandros, Wang, Kong, Zhao, Weiss, Rivella, Weiss, Persons: Analysis of alpha hemoglobin stabilizing protein overexpression in murine β-thalassemia. in American journal of hematology 2010 (PubMed)

  2. Human Monoclonal aHSP Primary Antibody for ELISA, WB - ABIN526641 : Wang, Fang, Guo, Ren, Zhang: Transgenic human alpha-hemoglobin stabilizing protein could partially relieve betaIVS-2-654-thalassemia syndrome in model mice. in Human gene therapy 2010 (PubMed)

More Antibodies against aHSP Interaction Partners

Human alpha Hemoglobin Stabilizing Protein (aHSP) interaction partners

  1. AHSP is predominantly expressed in erythroid precursors in bone marrow biopsy specimens from patients with hematologic malignancies.

  2. AHSP expression was higher in patients with sickle cell anemia versus thalassemia, with no significant difference between BTM and BTI. Expression was higher in patients with NTDT and on hydroxyurea therapy.

  3. In maturing RBC (show CACNA1C Antibodies) progenitors AHSP bind to free alpha-globin (show HBA1 Antibodies) chains to increase the HbA (show SCN2A Antibodies) production. (Review)

  4. analysis showed binding of STAT3 (show STAT3 Antibodies) to AHSP promoter and binding was significantly augmented with IL6 (show IL6 Antibodies) stimulation and upon alpha-globin (show HBA1 Antibodies) overexpression

  5. The relationship between AHSP gene expression, disease severity, and the beta/alpha globin (show HBA1 Antibodies) mRNA ratio was studied among different homozygote beta-thalassemia patients.

  6. alpha-Hemoglobin-stabilizing protein (AHSP) perturbs the proximal heme pocket of oxy (show GCG Antibodies)-alpha-hemoglobin and weakens the iron-oxygen bond.

  7. alpha-Hemoglobin stabilizing protein (AHSP) markedly decreases the redox potential and reactivity of alpha-subunits of human HbA (show SCN2A Antibodies) with hydrogen peroxide.

  8. AHSP acts as a molecular chaperone (show HSP90AA1 Antibodies) by rapidly binding and stabilizing met-alpha hemichrome folding intermediates

  9. AHSP could be a secondary compensatory mechanism in red blood cells to counterbalance the excess of alpha-globin (show HBA1 Antibodies) chains in HbE (show HBe1 Antibodies)/beta-thalassaemia individuals.

  10. NF-E2 (show NFE2 Antibodies) may play an important role in AHSP gene regulation, providing new insights into the molecular mechanisms underlying the erythroid-specific expression of AHSP as well as new possibilities for beta-thalassemia treatment

Mouse (Murine) alpha Hemoglobin Stabilizing Protein (aHSP) interaction partners

  1. role of alpha-hemoglobin stabilizing protein in hemoglobin assembly

  2. Endogenous AHSP is not limiting for alpha-globin (show HBA-A1 Antibodies) detoxification in beta-thalassemic mice.

  3. activin A (show INHBA Antibodies) does not appear to affect the exocrine or endocrine components of the pancreas, but promotes differentiation of pancreatic tissue into intestine via a Shh (show SHH Antibodies)-dependent mechanism

  4. Loss of AHSP impairs erythropoiesis and exacerbates beta-thalassemia.

  5. These results support the hypothesis that EKLF (show KLF1 Antibodies) acts as a transcription factor and a chromatin modulator for the AHSP and beta-globin (show HBB Antibodies) genes and indicate that EKLF (show KLF1 Antibodies) may play similar roles for other erythroid genes.

  6. developmental stage- and differentiation state-specific regulation of the nuclear transport of EKLF (show KLF1 Antibodies) might be one of the steps necessary for the switch-on of the mammalian adult beta globin (show HBB Antibodies) gene transcription

  7. AHSP also acts as a molecular chaperone to stabilize nascent alpha-globin for hemoglobin A assembly

  8. The expression of AHSP in a subclone of murine erythroleukemia cells in relationship to prion protein (show PRNP Antibodies) on the cell surface is reported.

aHSP Antigen Profile

Protein Summary

Act as a chaperone to prevent the harmful aggregation of alpha-hemoglobin during normal erythroid cell development. Specifically protects free alpha-hemoglobin from precipitation (By similarity).

Gene names and symbols associated with aHSP

  • alpha hemoglobin stabilizing protein (AHSP) antibody
  • erythroid associated factor (LOC100340962) antibody
  • alpha hemoglobin stabilizing protein (Ahsp) antibody
  • alpha-hemoglobin-stabilizing protein-like (LOC100620111) antibody
  • AHSP antibody
  • EDRF antibody
  • Eraf antibody

Protein level used designations for aHSP

alpha hemoglobin stabilizing protein , erythroid associated factor , alpha hemoglobin stabilising protein , alpha-hemoglobin-stabilizing protein , erythroid differentiation associated factor , erythroid differentiation-related factor , erythroid-associated factor

GENE ID SPECIES
454073 Pan troglodytes
714392 Macaca mulatta
100127218 Ovis aries
100340962 Oryctolagus cuniculus
51327 Homo sapiens
170812 Mus musculus
338381 Bos taurus
293522 Rattus norvegicus
100712877 Cavia porcellus
100620111 Sus scrofa
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