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Act as a chaperone to prevent the harmful aggregation of alpha-hemoglobin during normal erythroid cell development. Additionally we are shipping aHSP Proteins (17) and aHSP Kits (13) and many more products for this protein.
Showing 10 out of 39 products:
Mouse (Murine) Polyclonal aHSP Primary Antibody for FM, IHC (fp) - ABIN1043696
Nasimuzzaman, Khandros, Wang, Kong, Zhao, Weiss, Rivella, Weiss, Persons: Analysis of alpha hemoglobin stabilizing protein overexpression in murine β-thalassemia. in American journal of hematology 2010
Human Monoclonal aHSP Primary Antibody for ELISA, WB - ABIN526641
Wang, Fang, Guo, Ren, Zhang: Transgenic human alpha-hemoglobin stabilizing protein could partially relieve betaIVS-2-654-thalassemia syndrome in model mice. in Human gene therapy 2010
AHSP is predominantly expressed in erythroid precursors in bone marrow biopsy specimens from patients with hematologic malignancies.
AHSP expression was higher in patients with sickle cell anemia versus thalassemia, with no significant difference between BTM and BTI. Expression was higher in patients with NTDT and on hydroxyurea therapy.
In maturing RBC (show CACNA1C Antibodies) progenitors AHSP bind to free alpha-globin (show HBA1 Antibodies) chains to increase the HbA (show SCN2A Antibodies) production. (Review)
analysis showed binding of STAT3 (show STAT3 Antibodies) to AHSP promoter and binding was significantly augmented with IL6 (show IL6 Antibodies) stimulation and upon alpha-globin (show HBA1 Antibodies) overexpression
The relationship between AHSP gene expression, disease severity, and the beta/alpha globin (show HBA1 Antibodies) mRNA ratio was studied among different homozygote beta-thalassemia patients.
alpha-Hemoglobin-stabilizing protein (AHSP) perturbs the proximal heme pocket of oxy (show GCG Antibodies)-alpha-hemoglobin and weakens the iron-oxygen bond.
alpha-Hemoglobin stabilizing protein (AHSP) markedly decreases the redox potential and reactivity of alpha-subunits of human HbA (show SCN2A Antibodies) with hydrogen peroxide.
AHSP acts as a molecular chaperone (show HSP90AA1 Antibodies) by rapidly binding and stabilizing met-alpha hemichrome folding intermediates
AHSP could be a secondary compensatory mechanism in red blood cells to counterbalance the excess of alpha-globin (show HBA1 Antibodies) chains in HbE (show HBe1 Antibodies)/beta-thalassaemia individuals.
NF-E2 (show NFE2 Antibodies) may play an important role in AHSP gene regulation, providing new insights into the molecular mechanisms underlying the erythroid-specific expression of AHSP as well as new possibilities for beta-thalassemia treatment
role of alpha-hemoglobin stabilizing protein in hemoglobin assembly
Endogenous AHSP is not limiting for alpha-globin (show HBA-A1 Antibodies) detoxification in beta-thalassemic mice.
activin A (show INHBA Antibodies) does not appear to affect the exocrine or endocrine components of the pancreas, but promotes differentiation of pancreatic tissue into intestine via a Shh (show SHH Antibodies)-dependent mechanism
Loss of AHSP impairs erythropoiesis and exacerbates beta-thalassemia.
These results support the hypothesis that EKLF (show KLF1 Antibodies) acts as a transcription factor and a chromatin modulator for the AHSP and beta-globin (show HBB Antibodies) genes and indicate that EKLF (show KLF1 Antibodies) may play similar roles for other erythroid genes.
developmental stage- and differentiation state-specific regulation of the nuclear transport of EKLF (show KLF1 Antibodies) might be one of the steps necessary for the switch-on of the mammalian adult beta globin (show HBB Antibodies) gene transcription
AHSP also acts as a molecular chaperone to stabilize nascent alpha-globin for hemoglobin A assembly
The expression of AHSP in a subclone of murine erythroleukemia cells in relationship to prion protein (show PRNP Antibodies) on the cell surface is reported.
Act as a chaperone to prevent the harmful aggregation of alpha-hemoglobin during normal erythroid cell development. Specifically protects free alpha-hemoglobin from precipitation (By similarity).
alpha hemoglobin stabilizing protein
, erythroid associated factor
, alpha hemoglobin stabilising protein
, alpha-hemoglobin-stabilizing protein
, erythroid differentiation associated factor
, erythroid differentiation-related factor
, erythroid-associated factor