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alpha Hemoglobin Stabilizing Protein Proteins (aHSP)

Act as a chaperone to prevent the harmful aggregation of alpha-hemoglobin during normal erythroid cell development. Additionally we are shipping aHSP Antibodies (38) and aHSP Kits (14) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
aHSP 51327 Q9NZD4
aHSP 170812 Q9CY02
aHSP 293522  
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Top aHSP Proteins at antibodies-online.com

Showing 10 out of 17 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 16 Days
$272.80
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 7 to 8 Days
$242.00
Details
HOST_Escherichia coli (E. coli) Mouse His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$788.70
Details
HOST_Escherichia coli (E. coli) Rat His tag,GST tag 100 μg Log in to see 11 to 13 Days
$792.00
Details
HOST_Escherichia coli (E. coli) Human His tag,S tag 100 μg Log in to see 11 to 13 Days
$739.20
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,150.50
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details
HOST_Escherichia coli (E. coli) Rat Un-conjugated   100 μg Log in to see 9 to 19 Days
$967.75
Details
Human Un-conjugated   10 μg Log in to see 6 Days
$168.54
Details

aHSP Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Rat (Rattus)

Top referenced aHSP Proteins

  1. Human aHSP Protein expressed in Escherichia coli (E. coli) - ABIN666787 : dos Santos, Dore, Valentine, Shelat, Hardison, Ghosh, Wang, Eisenstein, Costa, Weiss: An iron responsive element-like stem-loop regulates alpha-hemoglobin-stabilizing protein mRNA. in The Journal of biological chemistry 2008 (PubMed)
    Show all 2 references for ABIN666787

  2. Human aHSP Protein expressed in Wheat germ - ABIN1353001 : Wang, Fang, Guo, Ren, Zhang: Transgenic human alpha-hemoglobin stabilizing protein could partially relieve betaIVS-2-654-thalassemia syndrome in model mice. in Human gene therapy 2010 (PubMed)

  3. Human aHSP Protein expressed in Escherichia coli (E. coli) - ABIN2006170 : Kihm, Kong, Hong, Russell, Rouda, Adachi, Simon, Blobel, Weiss: An abundant erythroid protein that stabilizes free alpha-haemoglobin. in Nature 2002 (PubMed)

More Proteins for alpha Hemoglobin Stabilizing Protein (aHSP) Interaction Partners

Human alpha Hemoglobin Stabilizing Protein (aHSP) interaction partners

  1. AHSP is predominantly expressed in erythroid precursors in bone marrow biopsy specimens from patients with hematologic malignancies.

  2. AHSP expression was higher in patients with sickle cell anemia versus thalassemia, with no significant difference between BTM and BTI. Expression was higher in patients with NTDT and on hydroxyurea therapy.

  3. In maturing RBC (show CACNA1C Proteins) progenitors AHSP bind to free alpha-globin (show HBA1 Proteins) chains to increase the HbA (show SCN2A Proteins) production. (Review)

  4. analysis showed binding of STAT3 (show STAT3 Proteins) to AHSP promoter and binding was significantly augmented with IL6 (show IL6 Proteins) stimulation and upon alpha-globin (show HBA1 Proteins) overexpression

  5. The relationship between AHSP gene expression, disease severity, and the beta/alpha globin (show HBA1 Proteins) mRNA ratio was studied among different homozygote beta-thalassemia patients.

  6. alpha-Hemoglobin-stabilizing protein (AHSP) perturbs the proximal heme pocket of oxy (show GCG Proteins)-alpha-hemoglobin and weakens the iron-oxygen bond.

  7. alpha-Hemoglobin stabilizing protein (AHSP) markedly decreases the redox potential and reactivity of alpha-subunits of human HbA (show SCN2A Proteins) with hydrogen peroxide.

  8. AHSP acts as a molecular chaperone (show HSP90AA1 Proteins) by rapidly binding and stabilizing met-alpha hemichrome folding intermediates

  9. AHSP could be a secondary compensatory mechanism in red blood cells to counterbalance the excess of alpha-globin (show HBA1 Proteins) chains in HbE (show HBe1 Proteins)/beta-thalassaemia individuals.

  10. NF-E2 (show NFE2 Proteins) may play an important role in AHSP gene regulation, providing new insights into the molecular mechanisms underlying the erythroid-specific expression of AHSP as well as new possibilities for beta-thalassemia treatment

Mouse (Murine) alpha Hemoglobin Stabilizing Protein (aHSP) interaction partners

  1. role of alpha-hemoglobin stabilizing protein in hemoglobin assembly

  2. Endogenous AHSP is not limiting for alpha-globin (show HBA-A1 Proteins) detoxification in beta-thalassemic mice.

  3. activin A (show INHBA Proteins) does not appear to affect the exocrine or endocrine components of the pancreas, but promotes differentiation of pancreatic tissue into intestine via a Shh (show SHH Proteins)-dependent mechanism

  4. Loss of AHSP impairs erythropoiesis and exacerbates beta-thalassemia.

  5. These results support the hypothesis that EKLF (show KLF1 Proteins) acts as a transcription factor and a chromatin modulator for the AHSP and beta-globin (show HBB Proteins) genes and indicate that EKLF (show KLF1 Proteins) may play similar roles for other erythroid genes.

  6. developmental stage- and differentiation state-specific regulation of the nuclear transport of EKLF (show KLF1 Proteins) might be one of the steps necessary for the switch-on of the mammalian adult beta globin (show HBB Proteins) gene transcription

  7. AHSP also acts as a molecular chaperone to stabilize nascent alpha-globin for hemoglobin A assembly

  8. The expression of AHSP in a subclone of murine erythroleukemia cells in relationship to prion protein (show PRNP Proteins) on the cell surface is reported.

aHSP Protein Profile

Protein Summary

Act as a chaperone to prevent the harmful aggregation of alpha-hemoglobin during normal erythroid cell development. Specifically protects free alpha-hemoglobin from precipitation (By similarity).

Gene names and symbols associated with aHSP

  • alpha hemoglobin stabilizing protein (AHSP)
  • erythroid associated factor (LOC100340962)
  • alpha hemoglobin stabilizing protein (Ahsp)
  • alpha-hemoglobin-stabilizing protein-like (LOC100620111)
  • AHSP protein
  • EDRF protein
  • Eraf protein

Protein level used designations for aHSP

alpha hemoglobin stabilizing protein , erythroid associated factor , alpha hemoglobin stabilising protein , alpha-hemoglobin-stabilizing protein , erythroid differentiation associated factor , erythroid differentiation-related factor , erythroid-associated factor

GENE ID SPECIES
454073 Pan troglodytes
714392 Macaca mulatta
100127218 Ovis aries
100340962 Oryctolagus cuniculus
51327 Homo sapiens
170812 Mus musculus
338381 Bos taurus
293522 Rattus norvegicus
100712877 Cavia porcellus
100620111 Sus scrofa
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