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B2M encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. Additionally we are shipping beta-2-Microglobulin Proteins (130) and beta-2-Microglobulin Kits (62) and many more products for this protein.
Showing 10 out of 662 products:
Human Monoclonal B2M Primary Antibody for EIA, FACS - ABIN112398
Hilgert, Horejsí, Kristofová: The use of murine monoclonal antibody B2M-01 for detection and purification of human beta 2-microglobulin. in Folia biologica 1985
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Human Monoclonal B2M Primary Antibody for EIA, FACS - ABIN112400
Khurana, Traum, Aivado, Wells, Guerrero, Grall, Libermann, Schachter: Urine proteomic profiling of pediatric nephrotic syndrome. in Pediatric nephrology (Berlin, Germany) 2006
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Human Polyclonal B2M Primary Antibody for EIA, IHC (p) - ABIN357931
Sakata, Chatani, Kameda, Sakurai, Naiki, Goto: Kinetic coupling of folding and prolyl isomerization of beta2-microglobulin studied by mutational analysis. in Journal of molecular biology 2008
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Human Polyclonal B2M Primary Antibody for EIA, IHC (p) - ABIN357932
Huang, Havel, Zhau, Qian, Lue, Chu, Nomura, Chung: Beta2-microglobulin signaling blockade inhibited androgen receptor axis and caused apoptosis in human prostate cancer cells. in Clinical cancer research : an official journal of the American Association for Cancer Research 2008
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Human Polyclonal B2M Primary Antibody for FACS, IHC (p) - ABIN389259
Gattoni-Celli, Kirsch, Timpane, Isselbacher: Beta 2-microglobulin gene is mutated in a human colon cancer cell line (HCT) deficient in the expression of HLA class I antigens on the cell surface. in Cancer research 1992
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Human Polyclonal B2M Primary Antibody for WB - ABIN2786771
Platt, Routledge, Homans, Radford: Fibril growth kinetics reveal a region of beta2-microglobulin important for nucleation and elongation of aggregation. in Journal of molecular biology 2008
The results show that, although other factors influence the fibril growth kinetics, a striking difference in the solubility of the proteins is a key determinant of the different amyloidogenicity of human B2M and mouse B2M.
Use of shRNA against beta-2-microglobulin offers a simple and effective approach to minimize immunogenicity of the main cellular components of cardiac tissue constructs in non-syngeneic recipients.
systemic B2M accumulation in aging blood promotes age-related cognitive dysfunction and impairs neurogenesis
Because all forms of H-2K(b) are internalized but little beta2m-receptive heavy chain is present at the cell surface, it is likely that beta2m dissociation and recognition of the heavy chain for lysosomal degradation take place in an endocytic compartment.
We report a novel dichotomous role of beta2m and CD1d, whereby these molecules differently regulate autoimmunity against phospholipid versus non-phospholipid autoantigens.
The goal of the present work was to study peculiarities in functioning of proteasomes and associated signaling pathways along with evaluation of NeuN (show RBFOX3 Antibodies) and gFAP (show GFAP Antibodies) expression in different sections of the brain in mice.
MHC I and b2m genes are both expressed in in human as well as mice during the developmental stages of cerebellar cortex
Knocking out beta 2 microglobulin abolishes NMDAR-dependent LTD in area CA1 of adult mouse hippocampus and is accompanied by memory deficits. MHC class I expression could be an unexpected cause of disrupted synaptic plasticity and cognitive deficits.
This study demonistrated that Deletion of beta-2-microglobulin ameliorates spinal cord lesion load and promotes recovery of brainstem NAA levels in a murine model of multiple sclerosis
Data show that tapasin (show TAPBP Antibodies) expression is enhanced by beta 2-microglobulin via both transcriptional and post-transcriptional mechanisms.
The chaperone crystallin, which is a mild modulator of the lag (show STMN1 Antibodies) phase of the variant fibrillogenesis, potently inhibits fibril elongation of the wild-type even once it is absorbed on D76N beta2-microglobulin fibrils.
B2M is a potential tissue biomarker and therapeutic target of borderline and malignant ovarian tumours and the dysregulation of B2M in these tumours may be mediated by the TGF-beta (show TGFB1 Antibodies) signaling pathway.
BTP and B2M levels are less affected than serum by amputation, and should be considered for future study of GFR (show RAPGEF5 Antibodies) estimation
Overexpression of B2M are associated with invasion, metastasis of the pancreatic ductal adenocarcinoma.
Serum Beta-2 Microglobulin level is elevated in Chronic Hepatitis C related chronic liver diseases and may be used as a marker for Chronic Hepatitis C disease progression towards cirrhosis and carcinoma.
Data suggest that, in modeling early assembly mechanisms for amyloidogenic beta2-microglobulin (B2M and/or truncated B2M, crosslinked and native), domain-swapped hinge region of B2M is key to both intra-molecular and inter-molecular interactions.
beta2M-mediated VEGFR-2/Akt/mTOR phosphorylation and tumor angiogenesis was significantly suppressed by over-expression of DKK-3.
ESAT-6/ESAT-6:CFP-10 can enter into the endoplasmic reticulum where it sequesters beta2M to inhibit cell surface expression of MHC-I-beta2M complexes, resulting in downregulation of class I-mediated antigen presentation.
The study presents the X-ray crystallographic structures of three families of oligomers formed by macrocyclic peptides containing a heptapeptide sequence derived from the amyloidogenic E chain of beta 2-microglobulin (B2M).
B2M contains alpha-helix, beta-sheet, turn, and random coil.
This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.
, beta-2 microglobulin
, beta-2-microglobulin C-terminal fragment (55 AA)
, beta2 microglobulin
, beta 2-m
, beta 2-microglobulin
, beta chain of MHC class I molecules
, beta 2 microglobulin
, beta-2-microglobulin-like protein
, beta 2 microglobulin (54 AA)