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beta-2-Microglobulin Proteins (B2M)

B2M encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. Additionally we are shipping beta-2-Microglobulin Antibodies (665) and beta-2-Microglobulin Kits (71) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat B2M B2M 24223 P07151
Mouse B2M B2M 12010 P01887
B2M 567 P61769
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Top beta-2-Microglobulin Proteins at antibodies-online.com

Showing 10 out of 128 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag beta-2-Microglobulin (B2M) (AA 22-119), (full length) protein (His tag) 50 μg Log in to see 9 to 11 Days
$242.00
Details
HOST_HEK-293 Cells Rat His tag 50 μg Log in to see 2 to 3 Days
$286.00
Details
HOST_HEK-293 Cells Human His tag 100 μg Log in to see 2 to 3 Days
$275.00
Details
HOST_HEK-293 Cells Cynomolgus His tag 100 μg Log in to see 2 to 3 Days
$275.00
Details
HOST_Human Cells Human His tag 100 μg Log in to see 16 Days
$173.80
Details
HOST_Human Cells Rat His tag 50 μg Log in to see 16 Days
$382.80
Details
HOST_Human Cells Cynomolgus His tag 50 μg Log in to see 16 Days
$382.80
Details
HOST_Human Cells Mouse His tag 50 μg Log in to see 16 Days
$382.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details

B2M Proteins by Origin and Source

Origin Expressed in Conjugate
Rat (Rattus) , , , ,

Mouse (Murine) ,

Human , , , , , , ,
, ,

Top referenced beta-2-Microglobulin Proteins

  1. Cynomolgus B2M Protein expressed in HEK-293 Cells - ABIN2180610 : Gorevic, Munoz, Casey, DiRaimondo, Stone, Prelli, Rodrigues, Poulik, Frangione: Polymerization of intact beta 2-microglobulin in tissue causes amyloidosis in patients on chronic hemodialysis. in Proceedings of the National Academy of Sciences of the United States of America 1986 (PubMed)
    Show all 5 references for ABIN2180610

  2. Human B2M Protein expressed in HEK-293 Cells - ABIN2180612 : Argilés, Derancourt, Jauregui-Adell, Mion, Demaille: Biochemical characterization of serum and urinary beta 2 microglobulin in end-stage renal disease patients. in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 1993 (PubMed)
    Show all 5 references for ABIN2180612

  3. Rat (Rattus) B2M Protein expressed in HEK-293 Cells - ABIN2180615 : Momoi, Suzuki, Titani, Hisanaga, Ogawa, Saito: Amino acid sequence of a modified beta 2-microglobulin in renal failure patient urine and long-term dialysis patient blood. in Clinica chimica acta; international journal of clinical chemistry 1995 (PubMed)
    Show all 5 references for ABIN2180615

  4. Mouse (Murine) B2M Protein expressed in Human Cells - ABIN2008449 : Miyata, Inagi, Wada, Ueda, Iida, Takahashi, Taniguchi, Maeda: Glycation of human beta 2-microglobulin in patients with hemodialysis-associated amyloidosis: identification of the glycated sites. in Biochemistry 1994 (PubMed)
    Show all 4 references for ABIN2008449

  5. Cynomolgus B2M Protein expressed in Human Cells - ABIN2009919 : Trinh, Smith, Kalverda, Phillips, Radford: Crystal structure of monomeric human beta-2-microglobulin reveals clues to its amyloidogenic properties. in Proceedings of the National Academy of Sciences of the United States of America 2002 (PubMed)
    Show all 4 references for ABIN2009919

  6. Human B2M Protein expressed in Human Cells - ABIN2004946 : He, Xu, Liu, Zeng: [Cloning of human beta-microglobulin gene and its high expression in Escherichia coli]. in Sheng wu gong cheng xue bao = Chinese journal of biotechnology 2005 (PubMed)
    Show all 4 references for ABIN2004946

  7. Rat (Rattus) B2M Protein expressed in Human Cells - ABIN2009601 : Kihara, Chatani, Iwata, Yamamoto, Matsuura, Nakagawa, Naiki, Goto: Conformation of amyloid fibrils of beta2-microglobulin probed by tryptophan mutagenesis. in The Journal of biological chemistry 2006 (PubMed)
    Show all 4 references for ABIN2009601

  8. Human B2M Protein expressed in Escherichia coli (E. coli) - ABIN1046607 : Haag-Weber, Mai, Hörl: Isolation of a granulocyte inhibitory protein from uraemic patients with homology of beta 2-microglobulin. in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 1994 (PubMed)
    Show all 2 references for ABIN1046607

More Proteins for beta-2-Microglobulin (B2M) Interaction Partners

Mouse (Murine) beta-2-Microglobulin (B2M) interaction partners

  1. The results show that, although other factors influence the fibril growth kinetics, a striking difference in the solubility of the proteins is a key determinant of the different amyloidogenicity of human B2M and mouse B2M.

  2. Use of shRNA against beta-2-microglobulin offers a simple and effective approach to minimize immunogenicity of the main cellular components of cardiac tissue constructs in non-syngeneic recipients.

  3. systemic B2M accumulation in aging blood promotes age-related cognitive dysfunction and impairs neurogenesis

  4. Because all forms of H-2K(b) are internalized but little beta2m-receptive heavy chain is present at the cell surface, it is likely that beta2m dissociation and recognition of the heavy chain for lysosomal degradation take place in an endocytic compartment.

  5. We report a novel dichotomous role of beta2m and CD1d, whereby these molecules differently regulate autoimmunity against phospholipid versus non-phospholipid autoantigens.

  6. The goal of the present work was to study peculiarities in functioning of proteasomes and associated signaling pathways along with evaluation of NeuN (show RBFOX3 Proteins) and gFAP (show GFAP Proteins) expression in different sections of the brain in mice.

  7. MHC I and b2m genes are both expressed in in human as well as mice during the developmental stages of cerebellar cortex

  8. Knocking out beta 2 microglobulin abolishes NMDAR-dependent LTD in area CA1 of adult mouse hippocampus and is accompanied by memory deficits. MHC class I expression could be an unexpected cause of disrupted synaptic plasticity and cognitive deficits.

  9. This study demonistrated that Deletion of beta-2-microglobulin ameliorates spinal cord lesion load and promotes recovery of brainstem NAA levels in a murine model of multiple sclerosis

  10. Data show that tapasin (show TAPBP Proteins) expression is enhanced by beta 2-microglobulin via both transcriptional and post-transcriptional mechanisms.

Human beta-2-Microglobulin (B2M) interaction partners

  1. BTP and B2M levels are less affected than serum by amputation, and should be considered for future study of GFR (show RAPGEF5 Proteins) estimation

  2. Overexpression of B2M are associated with invasion, metastasis of the pancreatic ductal adenocarcinoma.

  3. Serum Beta-2 Microglobulin level is elevated in Chronic Hepatitis C related chronic liver diseases and may be used as a marker for Chronic Hepatitis C disease progression towards cirrhosis and carcinoma.

  4. Data suggest that, in modeling early assembly mechanisms for amyloidogenic beta2-microglobulin (B2M and/or truncated B2M, crosslinked and native), domain-swapped hinge region of B2M is key to both intra-molecular and inter-molecular interactions.

  5. The results show that, although other factors influence the fibril growth kinetics, a striking difference in the solubility of the proteins is a key determinant of the different amyloidogenicity of human B2M and mouse B2M.

  6. beta2M-mediated VEGFR-2/Akt/mTOR phosphorylation and tumor angiogenesis was significantly suppressed by over-expression of DKK-3.

  7. ESAT-6/ESAT-6:CFP-10 can enter into the endoplasmic reticulum where it sequesters beta2M to inhibit cell surface expression of MHC-I-beta2M complexes, resulting in downregulation of class I-mediated antigen presentation.

  8. The study presents the X-ray crystallographic structures of three families of oligomers formed by macrocyclic peptides containing a heptapeptide sequence derived from the amyloidogenic E chain of beta 2-microglobulin (B2M).

  9. Serum cystatin C (show CST3 Proteins), urine NAG (show NAGLU Proteins), RBP (show RBP4 Proteins), and ET-1 (show EDN1 Proteins) levels were found to be insufficient for the evaluation of SCD (show SCD Proteins) nephropathy. Increased B2M/creatinie levels can be valuable in estimating possible glomerular and tubular damage in SCD (show SCD Proteins).

  10. Unfolding of the C-terminal portion of human beta 2 microglobulin may be related to amyloidogenicity.

Pig (Porcine) beta-2-Microglobulin (B2M) interaction partners

  1. B2M contains alpha-helix, beta-sheet, turn, and random coil.

Rhesus Monkey beta-2-Microglobulin (B2M) interaction partners

Zebrafish beta-2-Microglobulin (B2M) interaction partners

beta-2-Microglobulin (B2M) Protein Profile

Protein Summary

This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.

Gene names and symbols associated with beta-2-Microglobulin Proteins (B2M)

  • beta-2-microglobulin (B2M)
  • beta-2 microglobulin (b2m)
  • beta-2 microglobulin (B2m)
  • beta-2-microglobulin (b2m)
  • beta-2-microglobulin (B2m)
  • Beta-2-microglobulin-like (LOC100350679)
  • b2m protein
  • b2m-W01 protein
  • b2m-W03 protein
  • b2m-Z01 protein
  • b2m-Z02 protein
  • b2m-Z03 protein
  • B2MG protein
  • beta2-m protein
  • beta2m protein
  • bwm protein
  • Ly-m11 protein
  • wu:fa94c05 protein
  • wu:fb10a09 protein

Protein level used designations for beta-2-Microglobulin Proteins (B2M)

beta-2-microglobulin , beta-2 microglobulin , Beta-2-microglobulin , beta-2-microglobulin C-terminal fragment (55 AA) , beta2 microglobulin , beta 2-m , beta 2-microglobulin , beta chain of MHC class I molecules , beta-2-microglobin , lactollin , beta 2 microglobulin , beta-2-microglobulin-like protein , beta 2 microglobulin (54 AA)

GENE ID SPECIES
100174579 Pongo abelii
554191 Monodelphis domestica
100136933 Salmo salar
100381194 Papio anubis
100304470 Ictalurus punctatus
24223 Rattus norvegicus
12010 Mus musculus
100379556 Cavia porcellus
100689409 Cricetulus griseus
567 Homo sapiens
397033 Sus scrofa
414830 Gallus gallus
712428 Macaca mulatta
280729 Bos taurus
494145 Felis catus
100034203 Equus caballus
443295 Ovis aries
100855741 Canis lupus familiaris
30400 Danio rerio
101843036 Mesocricetus auratus
100404307 Callithrix jacchus
450170 Pan troglodytes
791104 Ornithorhynchus anatinus
398171 Xenopus laevis
478284 Canis lupus familiaris
100350679 Oryctolagus cuniculus
Selected quality suppliers for beta-2-Microglobulin Proteins (B2M)
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