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beta-Site APP-Cleaving Enzyme 2 Proteins (BACE2)

Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease and a frequent complication of Down syndrome. Additionally we are shipping beta-Site APP-Cleaving Enzyme 2 Antibodies (154) and beta-Site APP-Cleaving Enzyme 2 Kits (30) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
BACE2 25825 Q9Y5Z0
BACE2 56175 Q9JL18
BACE2 288227 Q6IE75
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Top beta-Site APP-Cleaving Enzyme 2 Proteins at antibodies-online.com

Showing 10 out of 14 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Human Cells Mouse His tag 50 μg Log in to see 16 Days
$437.80
Details
HOST_Escherichia coli (E. coli) Mouse His tag,GST tag 100 μg Log in to see 11 to 13 Days
$739.20
Details
HOST_Escherichia coli (E. coli) Rat His tag,GST tag 100 μg Log in to see 11 to 13 Days
$774.40
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human His tag   100 μg Log in to see 11 to 13 Days
$668.80
Details
HOST_NSO cells Mouse Un-conjugated   20 μg Log in to see 2 to 3 Days
$463.38
Details

BACE2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine) , , ,
, ,
Rat (Rattus)

More Proteins for beta-Site APP-Cleaving Enzyme 2 (BACE2) Interaction Partners

Human beta-Site APP-Cleaving Enzyme 2 (BACE2) interaction partners

  1. RNA-seq evidence of biallelic expression of BACE2 and 10 neighboring genes in at least one primary human tissue tested indicates that the expression of BACE2 is uncoupled from the control of the maternally inherited 5mCpG imprints at the WRB (show WRB Proteins) differentially methylated region (DMR (show WDR20 Proteins)) in disomic controls or trisomy (Down syndrome) individuals.

  2. Studies suggest that beta-Secretases BACE1 (show BACE Proteins)/2 plays an important role in retinal homeostasis and that BACE (show BACE Proteins) upregulation in response to stress is a protective measure.

  3. Data suggest that the amino acid residues would be essential for selectivity of beta-amyloid precursor protein cleavage enzymes BACE1 (show BACE Proteins) and BACE2 functions and could be sites for the design of selective inhibitors targeting either BACE1 (show BACE Proteins) or BACE2.

  4. Data identified two novel genome-wide significant associations: 2-h plasma glucose and HKDC1, and fasting C-peptide and BACE2.

  5. BACE2 cle (show BACE Proteins)aves the integral membrane form (show PMEL Proteins) of PMEL within the juxtamembrane domain, releasing the PMEL luminal domain into endosomal precursors for (show BACE Proteins) the formation of amyloid fibrils and downstream melanosome morphogenesis.

  6. Inhibiting Chrna7 (show CHRNA7 Proteins) expression markedly stimulated the production of Abeta (show APP Proteins) through the mechanism of increased expression of BACE1 (show BACE Proteins) and inhibited expression of BACE2 in SH-SY5Y cells.

  7. BACE2 overexpression in cultured cells was found to lower net amyloid ss-protein levels.

  8. The BACE2 distal promoter contains an activating cis (show CISH Proteins)-regulatory element that is responsive to Trichostatin A (TSA (show PRDX2 Proteins)) treatment according to promoter reporter assays in HEK (show EPHA3 Proteins) 293 cells.

  9. All these data point to a role for BACE2 in the IRbeta trafficking and insulin (show INS Proteins) signaling. In conclusion, BACE2 is hereby presented as an important enzyme in beta-cell function.

  10. Trransgenic BACE2 mice show increased anxiety-like behaviour along with increased numbers of noradrenergic neurones in the locus coeruleus.

Mouse (Murine) beta-Site APP-Cleaving Enzyme 2 (BACE2) interaction partners

  1. the BACE1 (show BACE Proteins) homologue BACE2 processes PMEL (show PMEL Proteins) to generate functional amyloids. BACE2 is highly expressed in pigment cells and Bace2(-/-) but not Bace1 (show BACE Proteins)(-/-) mice display coat color defects, implying a specific role for BACE2 during melanogenesis

  2. non-redundant roles of BACE1 (show BACE Proteins)/2 in ectodomain shedding with BACE1 (show BACE Proteins) regulating a broader and BACE2 a more distinct set of beta-cell-enriched substrates including two proteins of the seizure 6 protein (show SEZ6L Proteins) family (SEZ6L (show SEZ6L Proteins) and SEZ6L2 (show SEZ6L2 Proteins)).

  3. Tmem27 (show TMEM27 Proteins) dimerization is a dynamic process involving Bace2

  4. Bace2 is a beta (show SUCLA2 Proteins) cell-enriched protease that regulates pancreatic beta cell function and mass.

  5. The TgBACE2-APP (show APP Proteins) mice showed deregulation of BACE2 expression levels that were significantly increased with respect to single TgBACE2 mice.

  6. Data show that BACE1 (show BACE Proteins) knockout mice display a complex phenotype, and a combined deficiency of BACE2 and BACE1 (show BACE Proteins) enhanced the bace1 (show BACE Proteins)-/- lethality.

  7. BACE1 (show BACE Proteins) and BACE2 may act as alternative alpha-secretase-like proteases in proteolytic processing of IL-1R2 and APP (show APP Proteins)

  8. The presence of BACE2 in secretory granules of beta cells suggests that it may play a role in diabetes-associated amyloidogenesis.

beta-Site APP-Cleaving Enzyme 2 (BACE2) Protein Profile

Protein Summary

Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease and a frequent complication of Down syndrome. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein by 2 proteases, one of which is the protein encoded by this gene. This gene localizes to the 'Down critical region' of chromosome 21. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease. Three transcript variants encoding different isoforms have been described for this gene.

Gene names and symbols associated with BACE2

  • beta-site APP-cleaving enzyme 2 (BACE2)
  • beta-site APP-cleaving enzyme 2 (Bace2)
  • beta-site APP-cleaving enzyme 2 (LOC100342092)
  • 1110059C24Rik protein
  • AEPLC protein
  • AI850424 protein
  • ALP56 protein
  • ARP1 protein
  • ASP1 protein
  • ASP21 protein
  • BAE2 protein
  • CDA13 protein
  • CEAP1 protein
  • DRAP protein

Protein level used designations for BACE2

56 kDa aspartic-like protease , Down syndrome region aspartic protease , aspartyl protease 1 , beta-secretase 2 , beta-site amyloid beta A4 precursor protein-cleaving enzyme 2 , memapsin-1 , membrane-associated aspartic protease 1 , theta-secretase , transmembrane aspartic proteinase Asp1 , ASP1 , asp 1 , beta-site APP cleaving enzyme 2 , beta-site amyloid precursor protein cleaving enzyme 2

GENE ID SPECIES
25825 Homo sapiens
56175 Mus musculus
288227 Rattus norvegicus
100342092 Oryctolagus cuniculus
100720853 Cavia porcellus
100517374 Sus scrofa
478418 Canis lupus familiaris
534774 Bos taurus
418526 Gallus gallus
101102027 Ovis aries
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