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Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease and a frequent complication of Down syndrome. Additionally we are shipping beta-Site APP-Cleaving Enzyme 1 Kits (53) and beta-Site APP-Cleaving Enzyme 1 Proteins (34) and many more products for this protein.
Showing 10 out of 251 products:
Human Polyclonal BACE Primary Antibody for EIA, IHC (p) - ABIN358083
Xie, Guo: PAR-4 is involved in regulation of beta-secretase cleavage of the Alzheimer amyloid precursor protein. in The Journal of biological chemistry 2005
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Human Polyclonal BACE Primary Antibody for IHC (p), WB - ABIN392201
He, Li, Chang, Tang: GGA proteins mediate the recycling pathway of memapsin 2 (BACE). in The Journal of biological chemistry 2005
Show all 5 references for 392201
Human Polyclonal BACE Primary Antibody for WB - ABIN264995
Hussain, Powell, Howlett, Tew, Meek, Chapman, Gloger, Murphy, Southan, Ryan, Smith, Simmons, Walsh, Dingwall, Christie: Identification of a novel aspartic protease (Asp 2) as beta-secretase. in Molecular and cellular neurosciences 2000
Show all 4 references for 264995
Human Polyclonal BACE Primary Antibody for IHC (p), WB - ABIN401041
Vassar, Bennett, Babu-Khan, Kahn, Mendiaz, Denis, Teplow, Ross, Amarante, Loeloff, Luo, Fisher, Fuller, Edenson, Lile, Jarosinski, Biere, Curran, Burgess, Louis, Collins, Treanor, Rogers, Citron: Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. in Science (New York, N.Y.) 1999
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Human Polyclonal BACE Primary Antibody for IHC (p), WB - ABIN389517
Huang, Chang, Koelsch, Turner, Lupu, Tang: Internalization of exogenously added memapsin 2 (beta-secretase) ectodomain by cells is mediated by amyloid precursor protein. in The Journal of biological chemistry 2004
Show all 4 references for 389517
Human Polyclonal BACE Primary Antibody for WB - ABIN392200
Chiocco, Kulnane, Younkin, Younkin, Evin, Lamb: Altered amyloid-beta metabolism and deposition in genomic-based beta-secretase transgenic mice. in The Journal of biological chemistry 2004
Show all 4 references for 392200
Cow (Bovine) Polyclonal BACE Primary Antibody for IF, IHC - ABIN2782766
Shimizu, Tosaki, Kaneko, Hisano, Sakurai, Nukina: Crystal structure of an active form of BACE1, an enzyme responsible for amyloid beta protein production. in Molecular and cellular biology 2008
study supports the hypothesis that Abeta (show APP Antibodies) induces microtubule disruption in presynaptic dystrophic neurites that surround plaques, thus impairing axonal transport and leading to accumulation of BACE1 and exacerbation of amyloid pathology in Alzheimer's disease
Here, we demonstrate that Snapin (show SNAPIN Antibodies)-mediated retrograde transport plays a critical role in removing BACE1 from presynaptic terminals toward the soma, thus reducing synaptic Abeta (show APP Antibodies) production. Adeno (show ADORA2A Antibodies)-associated virus-mediated Snapin (show SNAPIN Antibodies) overexpression in the hippocampus of mutant hAPP mice significantly decreases synaptic Abeta (show APP Antibodies) levels, attenuates synapse loss, and thus rescues cognitive deficits. Our study uncovers a new pathway...
beta-site APP cleaving enzyme 1 (BACE1) is essential for amyloid beta protein production. We discovered that A673V mutation shifted the BACE1 cleavage site from the Glu (show GCG Antibodies)(11) to the Asp(1 (show BACE2 Antibodies)) site, resulting in much higher C99 level and C99/C89 ratio.
SEPT8 (show SEPT8 Antibodies) modulates beta-amyloidogenic processing of APP (show APP Antibodies) through a mechanism affecting the intracellular sorting and accumulation of BACE1.
the depletion of BIN1 (show BIN1 Antibodies) increases cellular BACE1 levels through impaired endosomal trafficking and reduces BACE1 lysosomal degradation, resulting in increased Ab production. Our findings provide a mechanistic role of BIN1 (show BIN1 Antibodies) in the pathogenesis of Alzheimer disease (AD), as a novel genetic regulator of BACE1 levels and Ab production
In an Alzheimer's disease mouse model we show that BACE-1 is upregulated at the blood-brain barrier compared to healthy controls.
study provides new insights into autophagy-mediated regulation of BACE1 turnover and APP (show APP Antibodies) processing, thus building a foundation for future development of potential Alzheimer's disease therapeutic strategies.
analysis suggests that some familial Alzheimer's disease mutations in APP (show APP Antibodies) are amyloidogenic and/or amyloidolytic via selection of alternative BACE1 cleavage sites
data indicate that Egr-1 (show EGR1 Antibodies) promotes Abeta (show APP Antibodies) synthesis via transcriptional activation of BACE-1 and suggest that Egr-1 (show EGR1 Antibodies) plays role in activation of BACE-1 and acceleration of Abeta (show APP Antibodies) synthesis in AD brain.
PD98059 had no influence on the expression of BACE1 and PS1 (show PSEN1 Antibodies).
Data suggest that trimerization of BACE1 requires transmembrane sequences (TMSs) and cytoplasmic domains, with residues Ala463 and Cys466 buried within trimer interface of the sulfur-rich core of TMSs; BACE1 appears to play role in compartmentalization of intracellular copper by transferring cytosolic copper to intracellular compartments.
in vitro BACE1-activity assays demonstrate that palmitoylation-dependent dimerization of APP (show APP Antibodies) promotes beta-cleavage of APP (show APP Antibodies) in lipid-rich detergent resistant cell membranes (DRMs), when compared to total APP (show APP Antibodies).
The circular RNA ciRS-7 promotes APP (show APP Antibodies) and BACE1 degradation in an NF-kappaB (show NFKB1 Antibodies)-dependent manner.
rs638405 in BACE1 was not associated with the risk of Alzheimer's disease (AD), rs638405 decreased the risk of apolipoprotein-E (show APOE Antibodies) epsilon4 (APOE4) positive AD patients, rs638405 also decreased the risk of Asian AD patients. Data of meta-analysis suggested rs638405 in BACE1 was a protective factor of AD.
In this study, we aimed to investigate the association of BACE1 rs490460 with the risk of Schizophrenia in an Iranian population. A significant association was observed between the rs490460 T allele and Schizophrenia ( p = 0.0002, odds ratio 0.69, 95% confidence interval 0.57-0.84).
findings demonstrate that USP8 (show USP8 Antibodies) plays a key role in the trafficking and degradation of BACE1 by deubiquitinating lysine 501.
Cassia obtusifolia extract and its major constituents are potent BACE1 inhibitors.
bace1 mutants display hypomyelination in the peripheral nervous system and supernumerary neuromasts while in bace2 (show BACE2 Antibodies) mutants the shape and migration of melanocytes is affected.
Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein encoded by this gene. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Multiple transcript variants encoding different isoforms have been described for this gene.
beta-site APP-cleaving enzyme 1
, beta-secretase 1
, beta-secretase 1 isoform A preproprotein
, beta-secretase 1 isoform B preproprotein
, beta-secretase 1 isoform C preproprotein
, beta-secretase 1-like
, beta-site APP-cleaving enzyme 2
, beta-secretase 2-like
, APP beta-secretase
, asp 2
, aspartyl protease 2
, beta-site amyloid precursor protein cleaving enzyme 1
, membrane-associated aspartic protease 2
, beta-secretase 1 precursor variant 1
, beta-site APP cleaving enzyme 1
, beta-site amyloid beta A4 precursor protein-cleaving enzyme
, transmembrane aspartic proteinase Asp2
, beta-site APP cleaving enzyme
, beta secretase 1