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Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease and a frequent complication of Down syndrome. Additionally we are shipping beta-Site APP-Cleaving Enzyme 1 Kits (53) and beta-Site APP-Cleaving Enzyme 1 Proteins (34) and many more products for this protein.
Showing 10 out of 244 products:
Human Polyclonal BACE Primary Antibody for EIA, IHC (p) - ABIN358083
Xie, Guo: PAR-4 is involved in regulation of beta-secretase cleavage of the Alzheimer amyloid precursor protein. in The Journal of biological chemistry 2005
Show all 5 references for ABIN358083
Human Polyclonal BACE Primary Antibody for IHC (p), WB - ABIN392201
He, Li, Chang, Tang: GGA proteins mediate the recycling pathway of memapsin 2 (BACE). in The Journal of biological chemistry 2005
Show all 5 references for ABIN392201
Human Polyclonal BACE Primary Antibody for WB - ABIN264995
Hussain, Powell, Howlett, Tew, Meek, Chapman, Gloger, Murphy, Southan, Ryan, Smith, Simmons, Walsh, Dingwall, Christie: Identification of a novel aspartic protease (Asp 2) as beta-secretase. in Molecular and cellular neurosciences 2000
Show all 4 references for ABIN264995
Human Polyclonal BACE Primary Antibody for IHC (p), WB - ABIN401041
Vassar, Bennett, Babu-Khan, Kahn, Mendiaz, Denis, Teplow, Ross, Amarante, Loeloff, Luo, Fisher, Fuller, Edenson, Lile, Jarosinski, Biere, Curran, Burgess, Louis, Collins, Treanor, Rogers, Citron: Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. in Science (New York, N.Y.) 1999
Show all 4 references for ABIN401041
Human Polyclonal BACE Primary Antibody for WB - ABIN392200
Huang, Chang, Koelsch, Turner, Lupu, Tang: Internalization of exogenously added memapsin 2 (beta-secretase) ectodomain by cells is mediated by amyloid precursor protein. in The Journal of biological chemistry 2004
Show all 4 references for ABIN392200
Human Polyclonal BACE Primary Antibody for IHC (p), WB - ABIN389517
Chiocco, Kulnane, Younkin, Younkin, Evin, Lamb: Altered amyloid-beta metabolism and deposition in genomic-based beta-secretase transgenic mice. in The Journal of biological chemistry 2004
Show all 4 references for ABIN389517
Human Monoclonal BACE Primary Antibody for FACS, IHC - ABIN4900525
Cheng, He, Lee, Yao, Li, Shen: High activities of BACE1 in brains with mild cognitive impairment. in The American journal of pathology 2013
Show all 3 references for ABIN4900525
Cow (Bovine) Polyclonal BACE Primary Antibody for IF, IHC - ABIN2782766
Shimizu, Tosaki, Kaneko, Hisano, Sakurai, Nukina: Crystal structure of an active form of BACE1, an enzyme responsible for amyloid beta protein production. in Molecular and cellular biology 2008
study provides new insights into autophagy-mediated regulation of BACE1 turnover and APP (show APP Antibodies) processing, thus building a foundation for future development of potential Alzheimer's disease therapeutic strategies.
analysis suggests that some familial Alzheimer's disease mutations in APP (show APP Antibodies) are amyloidogenic and/or amyloidolytic via selection of alternative BACE1 cleavage sites
data indicate that Egr-1 (show EGR1 Antibodies) promotes Abeta (show APP Antibodies) synthesis via transcriptional activation of BACE-1 and suggest that Egr-1 (show EGR1 Antibodies) plays role in activation of BACE-1 and acceleration of Abeta (show APP Antibodies) synthesis in AD brain.
PD98059 had no influence on the expression of BACE1 and PS1 (show PSEN1 Antibodies).
Three- and six-month-old female APP (show APP Antibodies)/PS1 (show PSEN1 Antibodies) double transgenic mice were used to study abnormal accumulation of BACE-1 protein in brains. We found a high immunoreactive density of BACE-1 protein on the outer layer of brain blood vessels, implicating BACE-1 protein as a central player in the pathogenesis of Alzheimer's disease.
Partial BACE1 reduction in a Down syndrome mouse model blocks Alzheimer-related endosomal anomalies and cholinergic neurodegeneration.
Review discussing the major discoveries of the past 3 (show EHD3 Antibodies) years concerning BACE1 biology and to what extent these could limit the use of BACE1 inhibitors in the clinic
The electrophysiological effects of BACE1 on KCNQ1 (show KCNQ1 Antibodies) reported here were independent of its enzymatic activity.
Results suggest that ubiquilin-1 (show UBQLN1 Antibodies) may mechanistically participate in Alzheimer's disease molecular pathogenesis by affecting BACE1 and thereby APP (show APP Antibodies) processing and Abeta (show APP Antibodies) accumulation
Results indicate that DISC (show DISC1 Antibodies)1 attenuates Abeta generation and cognitive deficits of APP/PS1 transgenic mice through promoting lysoso (show APP Antibodies)mal degradation of BACE1
in vitro BACE1-activity assays demonstrate that palmitoylation-dependent dimerization of APP (show APP Antibodies) promotes beta-cleavage of APP (show APP Antibodies) in lipid-rich detergent resistant cell membranes (DRMs), when compared to total APP (show APP Antibodies).
The circular RNA ciRS-7 promotes APP (show APP Antibodies) and BACE1 degradation in an NF-kappaB (show NFKB1 Antibodies)-dependent manner.
rs638405 in BACE1 was not associated with the risk of Alzheimer's disease (AD), rs638405 decreased the risk of apolipoprotein-E (show APOE Antibodies) epsilon4 (APOE4) positive AD patients, rs638405 also decreased the risk of Asian AD patients. Data of meta-analysis suggested rs638405 in BACE1 was a protective factor of AD.
In this study, we aimed to investigate the association of BACE1 rs490460 with the risk of Schizophrenia in an Iranian population. A significant association was observed between the rs490460 T allele and Schizophrenia ( p = 0.0002, odds ratio 0.69, 95% confidence interval 0.57-0.84).
findings demonstrate that USP8 (show USP8 Antibodies) plays a key role in the trafficking and degradation of BACE1 by deubiquitinating lysine 501.
Cassia obtusifolia extract and its major constituents are potent BACE1 inhibitors.
Suggest the potential of ginsenosides (Rb1 (show RB1 Antibodies), Rb2 (show RBL2 Antibodies), Rc, Re, Rg1 (show PPP1R3A Antibodies), and Rg3) for use in the development of therapeutic or preventive agents for Alzheimer's disease, especially through inhibition of AChE, BChE (show BCHE Antibodies) and BACE1 activities, as well as scavenging of ONOO(-) and inhibition of nitrotyrosine formation.
the behavior of the flap (show ALOX5AP Antibodies) tips during simulations is different between BACE1 and BACE2 (show BACE2 Antibodies). The BACE1 active site cavity is more spacious as compared to that of BACE2 (show BACE2 Antibodies). The analysis of 10S loop and 113S loop showed a similar trend to that of flaps, with the BACE1 loops being more flexible and less stable than those of BACE2 (show BACE2 Antibodies)
bace1 mutants display hypomyelination in the peripheral nervous system and supernumerary neuromasts while in bace2 (show BACE2 Antibodies) mutants the shape and migration of melanocytes is affected.
Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein encoded by this gene. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Multiple transcript variants encoding different isoforms have been described for this gene.
beta-site APP-cleaving enzyme 1
, beta-secretase 1
, beta-secretase 1 isoform A preproprotein
, beta-secretase 1 isoform B preproprotein
, beta-secretase 1 isoform C preproprotein
, beta-secretase 1-like
, beta-site APP-cleaving enzyme 2
, beta-secretase 2-like
, APP beta-secretase
, asp 2
, aspartyl protease 2
, beta-site amyloid precursor protein cleaving enzyme 1
, membrane-associated aspartic protease 2
, beta-secretase 1 precursor variant 1
, beta-site APP cleaving enzyme 1
, beta-site amyloid beta A4 precursor protein-cleaving enzyme
, transmembrane aspartic proteinase Asp2
, beta-site APP cleaving enzyme
, beta secretase 1