anti-beta-Site APP-Cleaving Enzyme 1 (BACE) Antibodies

Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease and a frequent complication of Down syndrome. Additionally we are shipping beta-Site APP-Cleaving Enzyme 1 Kits (56) and beta-Site APP-Cleaving Enzyme 1 Proteins (34) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
BACE 23821 P56818
BACE 29392 P56819
BACE 23621 P56817
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Top anti-beta-Site APP-Cleaving Enzyme 1 Antibodies at antibodies-online.com

Showing 10 out of 267 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IF, IHC, WB <b>WB Suggested Anti-BACE1 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:62500<br><b>Positive Control: </b>Human Liver 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of anti-BACE Antibody (S498) (ABIN392200) in mouse cerebellum tissue lysates (35 µg/lane). BACE (arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IHC (p), WB The anti-Phospho-BACE-S498 Pab (ABIN389517) is used in Western blot to detect Phospho-BACE-S498 in mouse brain tissue lysate Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of anti-BACE1 Antibody (N-term) (ABIN392201) in mouse heart tissue lysates (35 µg/lane). BACE1(arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human brain tissue reacted with BACE1 antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Mouse Un-conjugated CyTOF, FACS, IHC, WB Detection of Human BACE-1 by Western Blot. Western blot shows lysates of human brain (Alzheimer's disease hippocampus) tissue. PVDF Membrane was probed with 2 ug/mL of Mouse Anti-Human/Mouse BACE-1 Ectodomain Monoclonal Antibody. This experiment was conducted under reducing conditions. Detection of Human BACE-1 by Western Blot. Western blot shows lysates of human brain (Alzheimer's disease hippocampus) tissue. PVDF Membrane was probed with 2 ug/mL of Mouse Anti-Human/Mouse BACE-1 Ectodomain Monoclonal Antibody. This experiment was conducted under reducing conditions. 100 μg Log in to see 8 to 9 Days
$294.00
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat brain labeled with Rabbit Anti BACE1/ASP2 Polyclonal Antibody, Unconjugated (ABIN725705) at 1:200 followed by conjugation to the secondary antibody and DAB staining L1 rat brain lysates probed with Anti BACE1/ASP2 Polyclonal Antibody, Unconjugated (ABIN725705) at 1:200 overnight at 4 °C. Followed by conjugation to secondary antibody at 1:3000 for 90 min at 37 °C. Predicted band 51kD. Observed band size:51kD. 100 μL Log in to see 3 to 7 Days
$307.45
Details
Human Rabbit Un-conjugated WB 0.1 mg Log in to see 6 to 8 Days
$478.50
Details

BACE Antibodies by Reactivity, Application, Clonality and Conjugate

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Top referenced anti-beta-Site APP-Cleaving Enzyme 1 Antibodies

  1. Human Polyclonal BACE Primary Antibody for IF (p), IHC (p) - ABIN725705 : Tian, Guo, Wu, Ma, Zhao: Minocycline Alleviates Sevoflurane-Induced Cognitive Impairment in Aged Rats. in Cellular and molecular neurobiology 2015 (PubMed)
    Show all 4 Pubmed References

  2. Human Monoclonal BACE Primary Antibody for CyTOF, FACS - ABIN4900526 : Cheng, He, Lee, Yao, Li, Shen: High activities of BACE1 in brains with mild cognitive impairment. in The American journal of pathology 2013 (PubMed)
    Show all 3 Pubmed References

  3. Human Monoclonal BACE Primary Antibody for CyTOF, FACS - ABIN4900525 : Ahmed, Holler, Webb, Li, Beckett, Murphy: BACE1 and BACE2 enzymatic activities in Alzheimer's disease. in Journal of neurochemistry 2010 (PubMed)
    Show all 3 Pubmed References

  4. Human Polyclonal BACE Primary Antibody for IHC (p), WB - ABIN392201 : Xie, Guo: PAR-4 is involved in regulation of beta-secretase cleavage of the Alzheimer amyloid precursor protein. in The Journal of biological chemistry 2005 (PubMed)
    Show all 5 Pubmed References

  5. Cow (Bovine) Polyclonal BACE Primary Antibody for IHC (p) - ABIN2477571 : Rossner, Lange-Dohna, Zeitschel, Perez-Polo: Alzheimer's disease beta-secretase BACE1 is not a neuron-specific enzyme. in Journal of neurochemistry 2005 (PubMed)

  6. Human Monoclonal BACE Primary Antibody for IHC, WB - ABIN4282833 : Prior, Dargusch, Ehren, Chiruta, Schubert: The neurotrophic compound J147 reverses cognitive impairment in aged Alzheimer's disease mice. in Alzheimer's research & therapy 2014 (PubMed)

  7. Human Polyclonal BACE Primary Antibody for WB - ABIN550289 : Vassar, Bennett, Babu-Khan, Kahn, Mendiaz, Denis, Teplow, Ross, Amarante, Loeloff, Luo, Fisher, Fuller, Edenson, Lile, Jarosinski, Biere, Curran, Burgess, Louis, Collins, Treanor, Rogers, Citron: Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. in Science (New York, N.Y.) 1999 (PubMed)
    Show all 3 Pubmed References

More Antibodies against beta-Site APP-Cleaving Enzyme 1 Interaction Partners

Mouse (Murine) beta-Site APP-Cleaving Enzyme 1 (BACE) interaction partners

  1. Results indicate that SNX4 (show SNX4 Antibodies)-mediated regulation of the steady-state levels and trafficking of BACE1, as well as the subsequent increase in BACE1-mediated cleavage, may be relevant to Alzheimer's disease progression.

  2. In conclusion, glucocorticoid couples mGR (show GRHL1 Antibodies) with Galphas (show GNAS Antibodies) and triggers cAMP-PKA-CREB (show CREB1 Antibodies) axis dependent on the lipid raft to stimulate BACE1 upregulation and Abeta (show APP Antibodies) generation.SIGNIFICANCE STATEMENT Patients with Alzheimer's disease (AD) have been growing sharply and stress is considered as the major environment factor of AD.

  3. study supports the hypothesis that Abeta (show APP Antibodies) induces microtubule disruption in presynaptic dystrophic neurites that surround plaques, thus impairing axonal transport and leading to accumulation of BACE1 and exacerbation of amyloid pathology in Alzheimer's disease

  4. Here, we demonstrate that Snapin (show SNAPIN Antibodies)-mediated retrograde transport plays a critical role in removing BACE1 from presynaptic terminals toward the soma, thus reducing synaptic Abeta (show APP Antibodies) production. Adeno (show ADORA2A Antibodies)-associated virus-mediated Snapin (show SNAPIN Antibodies) overexpression in the hippocampus of mutant hAPP mice significantly decreases synaptic Abeta (show APP Antibodies) levels, attenuates synapse loss, and thus rescues cognitive deficits. Our study uncovers a new pathway...

  5. beta-site APP cleaving enzyme 1 (BACE1) is essential for amyloid beta protein production. We discovered that A673V mutation shifted the BACE1 cleavage site from the Glu (show GCG Antibodies)(11) to the Asp(1 (show BACE2 Antibodies)) site, resulting in much higher C99 level and C99/C89 ratio.

  6. SEPT8 (show SEPT8 Antibodies) modulates beta-amyloidogenic processing of APP (show APP Antibodies) through a mechanism affecting the intracellular sorting and accumulation of BACE1.

  7. the depletion of BIN1 (show BIN1 Antibodies) increases cellular BACE1 levels through impaired endosomal trafficking and reduces BACE1 lysosomal degradation, resulting in increased Ab production. Our findings provide a mechanistic role of BIN1 (show BIN1 Antibodies) in the pathogenesis of Alzheimer disease (AD), as a novel genetic regulator of BACE1 levels and Ab production

  8. In an Alzheimer's disease mouse model we show that BACE-1 is upregulated at the blood-brain barrier compared to healthy controls.

  9. study provides new insights into autophagy-mediated regulation of BACE1 turnover and APP (show APP Antibodies) processing, thus building a foundation for future development of potential Alzheimer's disease therapeutic strategies.

  10. analysis suggests that some familial Alzheimer's disease mutations in APP (show APP Antibodies) are amyloidogenic and/or amyloidolytic via selection of alternative BACE1 cleavage sites

Human beta-Site APP-Cleaving Enzyme 1 (BACE) interaction partners

  1. Results indicate that SNX4 (show SNX4 Antibodies)-mediated regulation of the steady-state levels and trafficking of BACE1, as well as the subsequent increase in BACE1-mediated cleavage, may be relevant to Alzheimer's disease progression.

  2. We discuss how the underlying mechanisms can be conceived and develop scenarios how the regulation of ion conductances by BACE1 might shape electric activity in the intact and diseased brain and heart

  3. Study showed that serum deprivation enhances ADAM10 (show ADAM10 Antibodies)/17-mediated cleavage and secretion of enzymatically active BACE1. This could be the result of alterations in the lipid composition of the membrane that lead in disruption of membrane compartmentalization in lipid rafts and non-lipid rafts. At present the significance of BACE1 shedding in the development of Alzheimer's disease is unclear.

  4. Data suggest that trimerization of BACE1 requires transmembrane sequences (TMSs) and cytoplasmic domains, with residues Ala463 and Cys466 buried within trimer interface of the sulfur-rich core of TMSs; BACE1 appears to play role in compartmentalization of intracellular copper by transferring cytosolic copper to intracellular compartments.

  5. SEPT8 (show SEPT8 Antibodies) modulates beta-amyloidogenic processing of APP (show APP Antibodies) through a mechanism affecting the intracellular sorting and accumulation of BACE1.

  6. the depletion of BIN1 (show BIN1 Antibodies) increases cellular BACE1 levels through impaired endosomal trafficking and reduces BACE1 lysosomal degradation, resulting in increased Ab production. Our findings provide a mechanistic role of BIN1 (show BIN1 Antibodies) in the pathogenesis of Alzheimer disease (AD), as a novel genetic regulator of BACE1 levels and Ab production

  7. in vitro BACE1-activity assays demonstrate that palmitoylation-dependent dimerization of APP (show APP Antibodies) promotes beta-cleavage of APP (show APP Antibodies) in lipid-rich detergent resistant cell membranes (DRMs), when compared to total APP (show APP Antibodies).

  8. The circular RNA ciRS-7 promotes APP (show APP Antibodies) and BACE1 degradation in an NF-kappaB (show NFKB1 Antibodies)-dependent manner.

  9. rs638405 in BACE1 was not associated with the risk of Alzheimer's disease (AD), rs638405 decreased the risk of apolipoprotein-E (show APOE Antibodies) epsilon4 (APOE4) positive AD patients, rs638405 also decreased the risk of Asian AD patients. Data of meta-analysis suggested rs638405 in BACE1 was a protective factor of AD.

  10. analysis suggests that some familial Alzheimer's disease mutations in APP (show APP Antibodies) are amyloidogenic and/or amyloidolytic via selection of alternative BACE1 cleavage sites

Zebrafish beta-Site APP-Cleaving Enzyme 1 (BACE) interaction partners

  1. bace1 mutants display hypomyelination in the peripheral nervous system and supernumerary neuromasts while in bace2 (show BACE2 Antibodies) mutants the shape and migration of melanocytes is affected.

beta-Site APP-Cleaving Enzyme 1 (BACE) Antigen Profile

Protein Summary

Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein encoded by this gene. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Multiple transcript variants encoding different isoforms have been described for this gene.

Gene names and symbols associated with BACE

  • beta-site APP-cleaving enzyme 1 (BACE1) antibody
  • beta-site APP-cleaving enzyme 1 (MGC145931) antibody
  • beta-site APP-cleaving enzyme 1 (LOC100232107) antibody
  • beta-site APP-cleaving enzyme 2 (bace2) antibody
  • beta-site APP-cleaving enzyme 2 (BACE2) antibody
  • beta-site APP-cleaving enzyme 2 (LOC100224177) antibody
  • beta-site APP cleaving enzyme 1 (Bace1) antibody
  • beta-site APP-cleaving enzyme 1 (bace1) antibody
  • ASP2 antibody
  • BACE antibody
  • BACE1 antibody
  • BACE2 antibody
  • C76936 antibody
  • HSPC104 antibody
  • MGC68482 antibody
  • MGC68881 antibody
  • MGC145931 antibody
  • zgc:77409 antibody

Protein level used designations for BACE

beta-site APP-cleaving enzyme 1 , beta-secretase 1 , beta-secretase 1 isoform A preproprotein , beta-secretase 1 isoform B preproprotein , beta-secretase 1 isoform C preproprotein , beta-secretase 1-like , beta-site APP-cleaving enzyme 2 , beta-secretase 2-like , APP beta-secretase , ASP2 , asp 2 , aspartyl protease 2 , beta-site amyloid precursor protein cleaving enzyme 1 , memapsin-2 , membrane-associated aspartic protease 2 , beta-secretase 1 precursor variant 1 , beta-site APP cleaving enzyme 1 , beta-site amyloid beta A4 precursor protein-cleaving enzyme , transmembrane aspartic proteinase Asp2 , beta-site APP cleaving enzyme , beta secretase 1

GENE ID SPECIES
100071137 Equus caballus
451573 Pan troglodytes
697694 Macaca mulatta
779940 Xenopus (Silurana) tropicalis
100025518 Monodelphis domestica
100232107 Taeniopygia guttata
100459804 Pongo abelii
380307 Xenopus laevis
398806 Xenopus laevis
747819 Pan troglodytes
100016587 Monodelphis domestica
100216145 Xenopus (Silurana) tropicalis
100224177 Taeniopygia guttata
100406072 Callithrix jacchus
100602656 Nomascus leucogenys
23821 Mus musculus
29392 Rattus norvegicus
100135485 Cavia porcellus
23621 Homo sapiens
614333 Bos taurus
403005 Danio rerio
419768 Gallus gallus
489390 Canis lupus familiaris
100511707 Sus scrofa
100343442 Oryctolagus cuniculus
101119667 Ovis aries
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