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Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease and a frequent complication of Down syndrome. Additionally we are shipping beta-Site APP-Cleaving Enzyme 1 Kits (50) and beta-Site APP-Cleaving Enzyme 1 Proteins (34) and many more products for this protein.
Showing 10 out of 249 products:
Human Polyclonal BACE Primary Antibody for EIA, IHC (p) - ABIN358083
Xie, Guo: PAR-4 is involved in regulation of beta-secretase cleavage of the Alzheimer amyloid precursor protein. in The Journal of biological chemistry 2005
Show all 5 references for ABIN358083
Human Polyclonal BACE Primary Antibody for IHC (p), WB - ABIN392201
He, Li, Chang, Tang: GGA proteins mediate the recycling pathway of memapsin 2 (BACE). in The Journal of biological chemistry 2005
Show all 5 references for ABIN392201
Human Polyclonal BACE Primary Antibody for WB - ABIN264995
Hussain, Powell, Howlett, Tew, Meek, Chapman, Gloger, Murphy, Southan, Ryan, Smith, Simmons, Walsh, Dingwall, Christie: Identification of a novel aspartic protease (Asp 2) as beta-secretase. in Molecular and cellular neurosciences 2000
Show all 4 references for ABIN264995
Human Polyclonal BACE Primary Antibody for IHC (p), WB - ABIN401041
Vassar, Bennett, Babu-Khan, Kahn, Mendiaz, Denis, Teplow, Ross, Amarante, Loeloff, Luo, Fisher, Fuller, Edenson, Lile, Jarosinski, Biere, Curran, Burgess, Louis, Collins, Treanor, Rogers, Citron: Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. in Science (New York, N.Y.) 1999
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Human Polyclonal BACE Primary Antibody for WB - ABIN392200
Huang, Chang, Koelsch, Turner, Lupu, Tang: Internalization of exogenously added memapsin 2 (beta-secretase) ectodomain by cells is mediated by amyloid precursor protein. in The Journal of biological chemistry 2004
Show all 4 references for ABIN392200
Human Polyclonal BACE Primary Antibody for IHC (p), WB - ABIN389517
Chiocco, Kulnane, Younkin, Younkin, Evin, Lamb: Altered amyloid-beta metabolism and deposition in genomic-based beta-secretase transgenic mice. in The Journal of biological chemistry 2004
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Human Monoclonal BACE Primary Antibody for IHC, WB - ABIN4282833
Prior, Dargusch, Ehren, Chiruta, Schubert: The neurotrophic compound J147 reverses cognitive impairment in aged Alzheimer's disease mice. in Alzheimer's research & therapy 2014
Chicken Polyclonal BACE Primary Antibody for IHC, WB - ABIN2782766
Shimizu, Tosaki, Kaneko, Hisano, Sakurai, Nukina: Crystal structure of an active form of BACE1, an enzyme responsible for amyloid beta protein production. in Molecular and cellular biology 2008
PD98059 had no influence on the expression of BACE1 and PS1 (show PSEN1 Antibodies).
Three- and six-month-old female APP (show APP Antibodies)/PS1 (show PSEN1 Antibodies) double transgenic mice were used to study abnormal accumulation of BACE-1 protein in brains. We found a high immunoreactive density of BACE-1 protein on the outer layer of brain blood vessels, implicating BACE-1 protein as a central player in the pathogenesis of Alzheimer's disease.
Partial BACE1 reduction in a Down syndrome mouse model blocks Alzheimer-related endosomal anomalies and cholinergic neurodegeneration.
Review discussing the major discoveries of the past 3 (show EHD3 Antibodies) years concerning BACE1 biology and to what extent these could limit the use of BACE1 inhibitors in the clinic
The electrophysiological effects of BACE1 on KCNQ1 (show KCNQ1 Antibodies) reported here were independent of its enzymatic activity.
Results suggest that ubiquilin-1 (show UBQLN1 Antibodies) may mechanistically participate in Alzheimer's disease molecular pathogenesis by affecting BACE1 and thereby APP (show APP Antibodies) processing and Abeta (show APP Antibodies) accumulation
Results indicate that DISC (show DISC1 Antibodies)1 attenuates Abeta generation and cognitive deficits of APP/PS1 transgenic mice through promoting lysoso (show APP Antibodies)mal degradation of BACE1
A single bout of exercise reduced BACE1 cortical content and activity in obese mice.
reduction in miR (show MLXIP Antibodies)-186 levels during aging may lead to the up-regulation of BACE1 in the brain, thereby increasing a risk for Alzheimer's disease
reveal Dicer1 (show DICER1 Antibodies)-miR (show MLXIP Antibodies)-328-Bace1 signalling as a determinant of brown adipose tissue function
the behavior of the flap (show ALOX5AP Antibodies) tips during simulations is different between BACE1 and BACE2 (show BACE2 Antibodies). The BACE1 active site cavity is more spacious as compared to that of BACE2 (show BACE2 Antibodies). The analysis of 10S loop and 113S loop showed a similar trend to that of flaps, with the BACE1 loops being more flexible and less stable than those of BACE2 (show BACE2 Antibodies)
Results suggest that DISC1 (show DISC1 Antibodies) interacts with BACE1 and promotes lysosomal degradation of BACE1, thus reducing the generation of Abeta (show APP Antibodies)
GG genotype and G allele of BACE1 gene rs638405 probably increase the risk of AD. [META-ANALYSIS]
study reports that sAbetaPPalpha, the product of the cleavage of AbetaPP by alpha-secretase, is a potent endogenous direct inhibitor of the BACE enzyme, and that its inhibition is likely by an allosteric mechanism
p38alpha (show MAPK14 Antibodies) MAPK (show MAPK1 Antibodies) plays a critical role in the regulation of BACE1 degradation and Abeta (show APP Antibodies) generation in Alzheimer Disease pathogenesis
this is the first study to acquire a DNA aptamer that exhibited binding specificity to BACE1 and inhibited its activity.
Results reveal a link between p25 (show LCN2 Antibodies) and BACE1 in Alzheimer disease (AD) brains and suggest that upregulated Cdk5 (show CDK5 Antibodies) activation by p25 (show LCN2 Antibodies) accelerates AD pathogenesis by enhancing BACE1 activity via phosphorylation.
the Alzheimer's disease-protective 'Icelandic' mutation greatly attenuates APP (show APP Antibodies)-BACE-1 interactions, suggesting a mechanistic basis for protection.
bace1 mutants display hypomyelination in the peripheral nervous system and supernumerary neuromasts while in bace2 (show BACE2 Antibodies) mutants the shape and migration of melanocytes is affected.
Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein encoded by this gene. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Multiple transcript variants encoding different isoforms have been described for this gene.
beta-site APP-cleaving enzyme 1
, beta-secretase 1
, beta-secretase 1 isoform A preproprotein
, beta-secretase 1 isoform B preproprotein
, beta-secretase 1 isoform C preproprotein
, beta-secretase 1-like
, beta-site APP-cleaving enzyme 2
, beta-secretase 2-like
, APP beta-secretase
, asp 2
, aspartyl protease 2
, beta-site amyloid precursor protein cleaving enzyme 1
, membrane-associated aspartic protease 2
, beta-secretase 1 precursor variant 1
, beta-site APP cleaving enzyme 1
, beta-site amyloid beta A4 precursor protein-cleaving enzyme
, transmembrane aspartic proteinase Asp2
, beta-site APP cleaving enzyme
, beta secretase 1