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beta-Site APP-Cleaving Enzyme 1 (BACE) ELISA Kits

Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease and a frequent complication of Down syndrome. Additionally we are shipping beta-Site APP-Cleaving Enzyme 1 Antibodies (244) and beta-Site APP-Cleaving Enzyme 1 Proteins (34) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
BACE 23821 P56818
BACE 29392 P56819
BACE 23621 P56817
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Top beta-Site APP-Cleaving Enzyme 1 ELISA Kits at antibodies-online.com

Showing 10 out of 53 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human 0.78 pg/mL 3.12-200 pg/mL Typical standard curve 96 Tests Log in to see 9 to 11 Days
$1,026.67
Details
Mouse 14.1 pg/mL 31.25-2000 pg/mL 96 Tests Log in to see 13 to 16 Days
$545.68
Details
Rat 6.7 pg/mL 15.62-1000 pg/mL 96 Tests Log in to see 13 to 16 Days
$576.00
Details
Human 1.0 ng/mL 1.0-250 ng/mL 96 Tests Log in to see 2 to 3 Days
$556.60
Details
Guinea Pig 1.0 pg/mL 50-1000 pg/mL   96 Tests Log in to see 11 to 13 Days
$707.14
Details
Rabbit 1.0 pg/mL 50-1000 pg/mL   96 Tests Log in to see 11 to 13 Days
$707.14
Details
Chicken 0.938 ng/mL 1.563-100 ng/mL   96 Tests Log in to see 8 to 9 Days
$715.00
Details
Monkey 0.375 ng/mL 0.625-40 ng/mL   96 Tests Log in to see 8 to 9 Days
$715.00
Details
Pig 0.375 ng/mL 0.625-40 ng/mL   96 Tests Log in to see 8 to 9 Days
$715.00
Details
Dog 1.0 pg/mL 50-1000 pg/mL   96 Tests Log in to see 11 to 13 Days
$707.14
Details

Top referenced beta-Site APP-Cleaving Enzyme 1 ELISA Kits

  1. Human BACE ELISA Kit for Sandwich ELISA - ABIN365021 : Qian, Ding, Cheng, Zhu, Zhao, Jin, Guan, Zhang, Chen, Xu: Early biomarkers for post-stroke cognitive impairment. in Journal of neurology 2012 (PubMed)

More ELISA Kits for beta-Site APP-Cleaving Enzyme 1 Interaction Partners

Mouse (Murine) beta-Site APP-Cleaving Enzyme 1 (BACE) interaction partners

  1. study provides new insights into autophagy-mediated regulation of BACE1 turnover and APP (show APP ELISA Kits) processing, thus building a foundation for future development of potential Alzheimer's disease therapeutic strategies.

  2. analysis suggests that some familial Alzheimer's disease mutations in APP (show APP ELISA Kits) are amyloidogenic and/or amyloidolytic via selection of alternative BACE1 cleavage sites

  3. data indicate that Egr-1 (show EGR1 ELISA Kits) promotes Abeta (show APP ELISA Kits) synthesis via transcriptional activation of BACE-1 and suggest that Egr-1 (show EGR1 ELISA Kits) plays role in activation of BACE-1 and acceleration of Abeta (show APP ELISA Kits) synthesis in AD brain.

  4. PD98059 had no influence on the expression of BACE1 and PS1 (show PSEN1 ELISA Kits).

  5. Three- and six-month-old female APP (show APP ELISA Kits)/PS1 (show PSEN1 ELISA Kits) double transgenic mice were used to study abnormal accumulation of BACE-1 protein in brains. We found a high immunoreactive density of BACE-1 protein on the outer layer of brain blood vessels, implicating BACE-1 protein as a central player in the pathogenesis of Alzheimer's disease.

  6. Partial BACE1 reduction in a Down syndrome mouse model blocks Alzheimer-related endosomal anomalies and cholinergic neurodegeneration.

  7. Review discussing the major discoveries of the past 3 (show EHD3 ELISA Kits) years concerning BACE1 biology and to what extent these could limit the use of BACE1 inhibitors in the clinic

  8. The electrophysiological effects of BACE1 on KCNQ1 (show KCNQ1 ELISA Kits) reported here were independent of its enzymatic activity.

  9. Results suggest that ubiquilin-1 (show UBQLN1 ELISA Kits) may mechanistically participate in Alzheimer's disease molecular pathogenesis by affecting BACE1 and thereby APP (show APP ELISA Kits) processing and Abeta (show APP ELISA Kits) accumulation

  10. Results indicate that DISC (show DISC1 ELISA Kits)1 attenuates Abeta generation and cognitive deficits of APP/PS1 transgenic mice through promoting lysoso (show APP ELISA Kits)mal degradation of BACE1

Human beta-Site APP-Cleaving Enzyme 1 (BACE) interaction partners

  1. in vitro BACE1-activity assays demonstrate that palmitoylation-dependent dimerization of APP (show APP ELISA Kits) promotes beta-cleavage of APP (show APP ELISA Kits) in lipid-rich detergent resistant cell membranes (DRMs), when compared to total APP (show APP ELISA Kits).

  2. The circular RNA ciRS-7 promotes APP (show APP ELISA Kits) and BACE1 degradation in an NF-kappaB (show NFKB1 ELISA Kits)-dependent manner.

  3. rs638405 in BACE1 was not associated with the risk of Alzheimer's disease (AD), rs638405 decreased the risk of apolipoprotein-E (show APOE ELISA Kits) epsilon4 (APOE4) positive AD patients, rs638405 also decreased the risk of Asian AD patients. Data of meta-analysis suggested rs638405 in BACE1 was a protective factor of AD.

  4. analysis suggests that some familial Alzheimer's disease mutations in APP (show APP ELISA Kits) are amyloidogenic and/or amyloidolytic via selection of alternative BACE1 cleavage sites

  5. In this study, we aimed to investigate the association of BACE1 rs490460 with the risk of Schizophrenia in an Iranian population. A significant association was observed between the rs490460 T allele and Schizophrenia ( p = 0.0002, odds ratio 0.69, 95% confidence interval 0.57-0.84).

  6. findings demonstrate that USP8 (show USP8 ELISA Kits) plays a key role in the trafficking and degradation of BACE1 by deubiquitinating lysine 501.

  7. Cassia obtusifolia extract and its major constituents are potent BACE1 inhibitors.

  8. Suggest the potential of ginsenosides (Rb1 (show RB1 ELISA Kits), Rb2 (show RBL2 ELISA Kits), Rc, Re, Rg1 (show PPP1R3A ELISA Kits), and Rg3) for use in the development of therapeutic or preventive agents for Alzheimer's disease, especially through inhibition of AChE, BChE (show BCHE ELISA Kits) and BACE1 activities, as well as scavenging of ONOO(-) and inhibition of nitrotyrosine formation.

  9. the behavior of the flap (show ALOX5AP ELISA Kits) tips during simulations is different between BACE1 and BACE2 (show BACE2 ELISA Kits). The BACE1 active site cavity is more spacious as compared to that of BACE2 (show BACE2 ELISA Kits). The analysis of 10S loop and 113S loop showed a similar trend to that of flaps, with the BACE1 loops being more flexible and less stable than those of BACE2 (show BACE2 ELISA Kits)

  10. Review discussing the major discoveries of the past 3 (show EHD3 ELISA Kits) years concerning BACE1 biology and to what extent these could limit the use of BACE1 inhibitors in the clinic

Zebrafish beta-Site APP-Cleaving Enzyme 1 (BACE) interaction partners

  1. bace1 mutants display hypomyelination in the peripheral nervous system and supernumerary neuromasts while in bace2 (show BACE2 ELISA Kits) mutants the shape and migration of melanocytes is affected.

beta-Site APP-Cleaving Enzyme 1 (BACE) Antigen Profile

Antigen Summary

Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein encoded by this gene. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Multiple transcript variants encoding different isoforms have been described for this gene.

Gene names and symbols associated with BACE

  • beta-site APP-cleaving enzyme 1 (BACE1) antibody
  • beta-site APP-cleaving enzyme 1 (MGC145931) antibody
  • beta-site APP-cleaving enzyme 1 (LOC100232107) antibody
  • beta-site APP-cleaving enzyme 2 (bace2) antibody
  • beta-site APP-cleaving enzyme 2 (BACE2) antibody
  • beta-site APP-cleaving enzyme 2 (LOC100224177) antibody
  • beta-site APP cleaving enzyme 1 (Bace1) antibody
  • beta-site APP-cleaving enzyme 1 (bace1) antibody
  • ASP2 antibody
  • BACE antibody
  • BACE1 antibody
  • BACE2 antibody
  • C76936 antibody
  • HSPC104 antibody
  • MGC68482 antibody
  • MGC68881 antibody
  • MGC145931 antibody
  • zgc:77409 antibody

Protein level used designations for BACE

beta-site APP-cleaving enzyme 1 , beta-secretase 1 , beta-secretase 1 isoform A preproprotein , beta-secretase 1 isoform B preproprotein , beta-secretase 1 isoform C preproprotein , beta-secretase 1-like , beta-site APP-cleaving enzyme 2 , beta-secretase 2-like , APP beta-secretase , ASP2 , asp 2 , aspartyl protease 2 , beta-site amyloid precursor protein cleaving enzyme 1 , memapsin-2 , membrane-associated aspartic protease 2 , beta-secretase 1 precursor variant 1 , beta-site APP cleaving enzyme 1 , beta-site amyloid beta A4 precursor protein-cleaving enzyme , transmembrane aspartic proteinase Asp2 , beta-site APP cleaving enzyme , beta secretase 1

GENE ID SPECIES
100071137 Equus caballus
451573 Pan troglodytes
697694 Macaca mulatta
779940 Xenopus (Silurana) tropicalis
100025518 Monodelphis domestica
100232107 Taeniopygia guttata
100459804 Pongo abelii
380307 Xenopus laevis
398806 Xenopus laevis
747819 Pan troglodytes
100016587 Monodelphis domestica
100216145 Xenopus (Silurana) tropicalis
100224177 Taeniopygia guttata
100406072 Callithrix jacchus
100602656 Nomascus leucogenys
23821 Mus musculus
29392 Rattus norvegicus
100135485 Cavia porcellus
23621 Homo sapiens
614333 Bos taurus
403005 Danio rerio
419768 Gallus gallus
489390 Canis lupus familiaris
100511707 Sus scrofa
100343442 Oryctolagus cuniculus
101119667 Ovis aries
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