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erythrocyte Membrane Protein Band 4.9 (Dematin) Proteins (EPB49)

Dematin, or EPB49, is an actin-bundling protein originally identified in the erythroid membrane skeleton. Additionally we are shipping erythrocyte Membrane Protein Band 4.9 (Dematin) Antibodies (54) and erythrocyte Membrane Protein Band 4.9 (Dematin) Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
EPB49 2039 Q08495
Mouse EPB49 EPB49 13829 Q9WV69
Rat EPB49 EPB49 361069  
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Top erythrocyte Membrane Protein Band 4.9 (Dematin) Proteins at antibodies-online.com

Showing 2 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

EPB49 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,

More Proteins for erythrocyte Membrane Protein Band 4.9 (Dematin) (EPB49) Interaction Partners

Human erythrocyte Membrane Protein Band 4.9 (Dematin) (EPB49) interaction partners

  1. When unphosphorylated, dematin's two F-actin binding domains move independent of one another permitting them to bind different F-actin filaments.

  2. the headpiece domain of dematin regulates calcium mobilization and signaling in platelets

  3. a novel functional role for dematin in regulating erythrocyte membrane function.

  4. Fast backbone dynamics probed at amide nitrogen versus carbonyl carbon sites for dematin headpiece C-terminal. The reduction of mobility in the loop region upon the S74E mutation can be seen from the (15)N order parameters.

  5. results suggest that phosphorylation of the dematin headpiece acts as a conformational switch within this headpiece domain

  6. a crucial role for this proline residue in structural stability and folding potential of HP (sub)domains consistent with Pro-Trp (show TBPL1 Proteins) stacking as a more general determinant of protein stability

  7. study investigated motions in the backbone of dematin headpiece domain and its mutant DHPS74E using several complementary NMR relaxation techniques

  8. results suggest that the core domain of dematin exhibits properties typical of a natively unfolded protein, while the headpiece domain is folded in a conformation essentially identical to its native structure

Mouse (Murine) erythrocyte Membrane Protein Band 4.9 (Dematin) (EPB49) interaction partners

  1. the headpiece domain of dematin regulates calcium mobilization and signaling in platelets

  2. remodeling of the host cell directed Plasmodium includes the recruitment of dematin, an actin-binding protein (show PFN1 Proteins) of the erythrocyte membrane skeleton and its repositioning to the parasite

  3. physiological significance of dematin and demonstrate a role for the headpiece domain in the maintenance of structural integrity and mechanical properties of erythrocytes in vivo.

  4. Dematin plays an essential role in the maintenance of erythrocyte shape and membrane stability; dematin-membrane interaction could link the junctional complex to the plasma membrane in erythroid cells.

  5. Dematin is expressed in skin, mostly in dermal fibroblasts and hypodermal adipocytes. Knockout mice lacking dematin exhibit hair loss.

  6. These results unveil a new function of dematin as a negative regulator of the RhoA (show RHOA Proteins) activation pathway with physiological implications for normal and pathogenic signaling pathways.

erythrocyte Membrane Protein Band 4.9 (Dematin) (EPB49) Protein Profile

Protein Summary

Dematin, or EPB49, is an actin-bundling protein originally identified in the erythroid membrane skeleton. Its actin-bundling activity is abolished upon phosphorylation by cAMP-dependent protein kinase and is restored after dephosphorylation (Rana et al., 1993

Gene names and symbols associated with EPB49

  • erythrocyte membrane protein band 4.9 (dematin) (epb49)
  • erythrocyte membrane protein band 4.9 (dematin) (EPB49)
  • erythrocyte membrane protein band 4.9 (dematin) (DMTN)
  • erythrocyte membrane protein band 4.9 (LOC100357787)
  • dematin actin binding protein (DMTN)
  • dematin actin binding protein (Dmtn)
  • AI325486 protein
  • dematin protein
  • DMT protein
  • Epb4.9 protein
  • Epb49 protein
  • MGC80597 protein
  • MGC108072 protein

Protein level used designations for EPB49

erythrocyte membrane protein band 4.9 (dematin) , dematin , dematin actin-binding protein , erythrocyte membrane protein band 4.9 , erythrocyte protein band 4.9

GENE ID SPECIES
444150 Xenopus laevis
486132 Canis lupus familiaris
548579 Xenopus (Silurana) tropicalis
706762 Macaca mulatta
741796 Pan troglodytes
100030483 Monodelphis domestica
100056495 Equus caballus
100173938 Pongo abelii
100357787 Oryctolagus cuniculus
100592471 Nomascus leucogenys
2039 Homo sapiens
13829 Mus musculus
361069 Rattus norvegicus
512981 Bos taurus
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