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The protein encoded by GGCT catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides, the penultimate step in glutathione catabolism, and may play a critical role in glutathione homeostasis. Additionally we are shipping gamma-Glutamylcyclotransferase Proteins (19) and gamma-Glutamylcyclotransferase Kits (5) and many more products for this protein.
Showing 10 out of 55 products:
Human Polyclonal GGCT Primary Antibody for EIA, WB - ABIN952507
Oakley, Yamada, Liu, Coggan, Clark, Board: The identification and structural characterization of C7orf24 as gamma-glutamyl cyclotransferase. An essential enzyme in the gamma-glutamyl cycle. in The Journal of biological chemistry 2008
Show all 3 references for ABIN952507
Human Polyclonal GGCT Primary Antibody for IHC, IHC (p) - ABIN4313404
Gromov, Gromova, Friis, Timmermans-Wielenga, Rank, Simon, Sauter, Moreira: Proteomic profiling of mammary carcinomas identifies C7orf24, a gamma-glutamyl cyclotransferase, as a potential cancer biomarker. in Journal of proteome research 2010
Show all 2 references for ABIN4313404
GGCT plays a critical role in glioma cell proliferation and may be a potential cancer therapeutic target.
GGCT is promising as a diagnostic marker and a therapeutic target for various cancers. This review summarizes these interesting findings.
G6PD (show G6PD Antibodies), GGCT, IDH1 (show IDH1 Antibodies), isocitrate dehydrogenase 2 (show IDH2 Antibodies) (NADP+,mitochondrial) (IDH2 (show IDH2 Antibodies)) and glutathione S-transferase pi 1(GSTP1 (show GSTP1 Antibodies)), five of the critical components of GSH pathway, contribute to chemoresistance.
GGCT plays a critical role in lung cancer cell proliferation.
Transcriptional silencing of the C7orf24 gene in the non-malignant cells is elicited through heterochromatin formation in its promoter region.
increased expression of GGCT was a common event among invasive esophageal squamous cell carcinoma tissues regardless of the depth of invasion. Lymph node metastasis and tumor differentiation correlated with GGCT expression
C7orf24 has been recognized as a potent marker for bladder and breast cancers. Studies on the role of gamma-glutamylcyclotransferace may aid in the control of malignant transformation of these cancers.
GGCT may be a biomarker of tumors in a limited range of organs.
C7orf24 overexpression defines a subgroup of breast tumors with poor clinical outcome.
CRF21 (show IFNAR1 Antibodies) might play an important role in the induction of apoptosis by GGO in leukemia U937 cells.
The protein encoded by this gene catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides, the penultimate step in glutathione catabolism, and may play a critical role in glutathione homeostasis. The encoded protein may also play a role in cell proliferation, and the expression of this gene is a potential marker for cancer. Pseudogenes of this gene are located on the long arm of chromosome 5 and the short arm of chromosomes 2 and 20. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
, gamma-glutamyl cyclotransferase
, gamma-glutamyl cyclotransferase-like 1
, cytochrome c-releasing factor 21
, gamma -glutamyl cyclotransferase