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The multi-pass membrane protein encoded by GABBR2 belongs to the G-protein coupled receptor 3 family and GABA-B receptor subfamily. Additionally we are shipping GABBR2 Proteins (9) and GABBR2 Kits (3) and many more products for this protein.
Showing 10 out of 200 products:
Human Polyclonal GABBR2 Primary Antibody for IF, WB - ABIN264843
Fritschy, Meskenaite, Weinmann, Honer, Benke, Mohler: GABAB-receptor splice variants GB1a and GB1b in rat brain: developmental regulation, cellular distribution and extrasynaptic localization. in The European journal of neuroscience 1999
Show all 6 references for ABIN264843
Human Monoclonal GABBR2 Primary Antibody for ICC, IF - ABIN2484081
Kaupmann, Huggel, Heid, Flor, Bischoff, Mickel, McMaster, Angst, Bittiger, Froestl, Bettler: Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors. in Nature 1997
Human Monoclonal GABBR2 Primary Antibody for IHC, ELISA - ABIN1724938
Balasubramanian, Fam, Hall: GABAB receptor association with the PDZ scaffold Mupp1 alters receptor stability and function. in The Journal of biological chemistry 2007
Cow (Bovine) Polyclonal GABBR2 Primary Antibody for IF, WB - ABIN372643
Kuramoto, Wilkins, Fairfax, Revilla-Sanchez, Terunuma, Tamaki, Iemata, Warren, Couve, Calver, Horvath, Freeman, Carling, Huang, Gonzales, Cooper, Smart, Pangalos, Moss: Phospho-dependent functional modulation of GABA(B) receptors by the metabolic sensor AMP-dependent protein kinase. in Neuron 2007
Human Polyclonal GABBR2 Primary Antibody for IHC (p), WB - ABIN654172
Oblak, Gibbs, Blatt: Decreased GABA(B) receptors in the cingulate cortex and fusiform gyrus in autism. in Journal of neurochemistry 2010
The rare variants in GABBR2 were significantly associated with smoking status.
GABBR2 receptors are expressed in aortic smooth muscle cells and regulate the [Ca(2 (show CA2 Antibodies)+)]i via a Gi/o-coupled receptor pathway and a phospholipase C (show PLC Antibodies) activation pathway.
Putative GABAA (show GABRg1 Antibodies) and ASIC1a (show ACCN2 Antibodies) channels functionally interact with each other, possibly via an inter-molecular association by forming a novel protein complex.
gamma-aminobutyric acidB receptor proteasomal degradation is mediated by the interaction of the GABAB2 C terminus with the proteasomal ATPase (show DNAH8 Antibodies) Rtp6 and regulated by neuronal activity
and GABABR2 proteins are reduced in the prefrontal cortex of aged rats but these reductions are not associated with spatial learning abilities.
The GABBR2 ectodomain adopts a constitutively open conformation, suggesting a structural asymmetry in the active state of GABA(B) receptor that is unique to the GABAergic system.
The results indicate that there may be specific GABA receptor gene expression variation in migraine, particularly involving the GABRA3 (show GABRA3 Antibodies) and GABBR2 genes.
The results of this study provided evidence of Gabbr2 Deficit in schizophrenia and mood disorders.
GABA(B) receptor subunit 2 (show CCT2 Antibodies) levels are significantly decreased in the cingulate cortex and fusiform gyrus of autism patients compared to controls.
variants of GABBR1 (show GABBR1 Antibodies) and GABBR2 are associated with nicotine dependence in European- and African-American populations
Immunoblotting and RT-PCR results showed that NIHL increased the expression of PKCgamma (show PRKCG Antibodies) but decreased that of GABABR1 (show GABBR1 Antibodies) and GABABR2 at both protein and mRNA levels in the CNC
GABABR2 has a role as a regulator of glutamine synthetase (show GLUL Antibodies) stability
siRNA knock-down of NgR1 (show NEUROG1 Antibodies) resulted in a selective increase of GABAB R1 and GABAB R2 protein and an increase in GIRK1 (show KCNJ3 Antibodies).
Cadm1 (show CADM1 Antibodies) specifically interacts with Mupp1 (show MPDZ Antibodies), and may form a ternary complex with Mupp1 (show MPDZ Antibodies)-GABBR2 in the cerebellum.
Gabbr1 (show GABBR1 Antibodies) and Gabbr2 transcription levels were altered in cerebral areas related to drug taking only in mice behaviorally classified as "addicted" drinkers
GABA(B)R is predominantly expressed by osteoblasts to negatively regulate osteoblastogenesis through down-regulation of BMP2 (show BMP2 Antibodies) expression toward disturbance of osteoclastogenesis after down-regulation of RANKL (show TNFSF11 Antibodies) expression in mouse bone.
results suggest that GABA(B)R2 protein levels are closely correlated with the partner subunit GABA(B)R1 (show GABBR1 Antibodies) protein levels in mouse brains during postnatal development in vivo
Our data suggest that association of GABAB(2) with GABAB(1 (show GABBR1 Antibodies)) is essential for receptor localization in distal processes but not absolutely necessary for signaling. Functional GABAB receptors may exist in neurons that naturally lack GABAB(2) subunits.
Activation of GABA(B) receptor by either GABA or the selective agonist baclofen induces ERK(1 (show MAPK3 Antibodies)/2) phosphorylation in cultured cerebellar granule neurons.
GABABR2 are expressed in the cerebellar cortex, supporting previous studies showing that inhibitory neurotransmission is highly patterned in the cerebellar cortex.
The multi-pass membrane protein encoded by this gene belongs to the G-protein coupled receptor 3 family and GABA-B receptor subfamily. The GABA-B receptors inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters, and the activity of ion channels and adenylyl cyclase. This receptor subunit forms an active heterodimeric complex with GABA-B receptor subunit 1, neither of which is effective on its own. Allelic variants of this gene have been associated with nicotine dependence.
gamma-aminobutyric acid (GABA) B receptor, 2
, gamma-aminobutyric acid type B receptor subunit 2-like
, G protein-coupled receptor 51
, G-protein coupled receptor 51
, GABA-B R2 receptor
, GABA-B receptor 2
, gamma-aminobutyric acid type B receptor subunit 2
, GABA-B receptor, R2 subunit
, gamma-aminobutyric acid B receptor 2
, gamma-aminobutyric acid type B receptor, subunit 2
, ortholog of human G protein-coupled receptor 51 GPR51