anti-gamma-aminobutyric Acid (GABA) A Receptor, alpha 2 (GABRA2) Antibodies

GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Additionally we are shipping GABRA2 Kits (21) and GABRA2 Proteins (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
GABRA2 2555 P47869
GABRA2 289606  
GABRA2 14395 P26048
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Top anti-GABRA2 Antibodies at antibodies-online.com

Showing 10 out of 74 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB <b>WB Suggested Anti-GABRA2 Antibody Titration: </b>1.25ug/ml<br><b>ELISA Titer: </b>1:62500<br><b>Positive Control: </b>HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$229.00
Details
Cow Rabbit Un-conjugated WB Host: Rabbit Target Name: GABRA2 Sample Type: OVCAR-3 Whole Cell lysates Antibody Dilution: 1.0ug/ml 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB Western blot analysis of GABRA2 Antibody (C-term) (ABIN653245) in NCI-H460, MDA-MB435 cell line lysates (35 µg/lane). GABRA2 (arrow) was detected using the purified polyclonal antibody. GABRA2 Antibody (C-term) (ABIN653245) IHC analysis in formalin fixed and paraffin embedded brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining 400 μL Log in to see 10 to 11 Days
$324.50
Details
Mouse Rabbit Un-conjugated WB Western blot of 10 ?g of rat cortex lysate showing immunolabeling of the ~53k ?2-subunit of the GABAA-R. Western Blot: GABA A Receptor alpha 2 Antibody [ABIN152495] - Western blot of 10 ug of rat brain lysate showing immunolabeling of the ~53 kda GABAaR a2. 0.05 mL Log in to see 7 to 9 Days
$381.94
Details
Human Rabbit Un-conjugated IHC, WB Western blot analysis of extracts of mouse brain, using GABRA2 antibody. 100 μL Log in to see 16 Days
$323.13
Details
Human Rabbit Un-conjugated IP, WB dilution: 1 : 1000, sample: unboiled synaptic membrane fraction of rat brain (LP1) 200 μL Log in to see 5 to 6 Days
$358.05
Details
Human Guinea Pig Un-conjugated ICC, IP, WB dilution: 1 : 1000, sample: unboiled synaptic membrane fraction of rat brain (LP1) Indirect immunostaining of hippocampus neurons (dilution 1 : 500). 100 μL Log in to see 5 to 6 Days
$358.05
Details
Human Rabbit Un-conjugated WB WB Image Sample (30 ug of whole cell lysate) A: NT2D1 10% SDS PAGE antibody diluted at 1:1000 100 μL Log in to see 1 to 2 Days
$358.60
Details
Human Rabbit Un-conjugated IHC, WB Immunohistochemical analysis of GABRA2 staining in rat brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the an Western blot analysis of GABRA2 expression in mouse brain (A), rat brain (B) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated FACS, IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat brain labeled with Anti GABRA2/GABA A Receptor alpha 2 Polyclonal Antibody, Unconjugated (ABIN1387528) at 1:200 followed by conjugation to the secondary antibody and DAB staining Mouse brain lysates probed with Rabbit Anti-GABRA2/GABA A Receptor alpha 2 Polyclonal Antibody, Unconjugated  ) at 1:300 overnight at 4˚C. Followed by a conjugated secondary antibody at 1:5000 for 90 min at 37˚C. 100 μL Log in to see 3 to 7 Days
$295.90
Details

GABRA2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-GABRA2 Antibodies

  1. Cow (Bovine) Polyclonal GABRA2 Primary Antibody for WB - ABIN2792259 : Hadingham, Wingrove, Le Bourdelles, Palmer, Ragan, Whiting: Cloning of cDNA sequences encoding human alpha 2 and alpha 3 gamma-aminobutyric acidA receptor subunits and characterization of the benzodiazepine pharmacology of recombinant alpha 1-, alpha 2-, alpha 3-, and alpha 5-containing human gamma-aminobutyric ac in Molecular pharmacology 1993 (PubMed)
    Show all 3 Pubmed References

  2. Human Polyclonal GABRA2 Primary Antibody for ICC, IP - ABIN1742454 : Herrera-Molina, Sarto-Jackson, Montenegro-Venegas, Heine, Smalla, Seidenbecher, Beesley, Gundelfinger, Montag: Structure of excitatory synapses and GABAA receptor localization at inhibitory synapses are regulated by neuroplastin-65. in The Journal of biological chemistry 2014 (PubMed)
    Show all 2 Pubmed References

  3. Mouse (Murine) Polyclonal GABRA2 Primary Antibody for WB - ABIN152495 : Werner, Swihart, Rau, Jia, Borghese, McCracken, Iyer, Fanselow, Oh, Sonner, Eger, Harrison, Harris, Homanics: Inhaled anesthetic responses of recombinant receptors and knockin mice harboring α2(S270H/L277A) GABA(A) receptor subunits that are resistant to isoflurane. in The Journal of pharmacology and experimental therapeutics 2010 (PubMed)

  4. Human Polyclonal GABRA2 Primary Antibody for IP, WB - ABIN1742453 : Ardi, Albrecht, Richter-Levin, Saha, Richter-Levin: Behavioral profiling as a translational approach in an animal model of posttraumatic stress disorder. in Neurobiology of disease 2016 (PubMed)

More Antibodies against GABRA2 Interaction Partners

Rhesus Monkey gamma-aminobutyric Acid (GABA) A Receptor, alpha 2 (GABRA2) interaction partners

  1. the developmental shift in GABA(A) receptor alpha subunit (show POLG Antibodies) expression continues through adolescence in primate dorsolateral prefrontal cortex

Human gamma-aminobutyric Acid (GABA) A Receptor, alpha 2 (GABRA2) interaction partners

  1. An uncorrected exploratory analysis revealed associations between GABBR2 (show GABBR2 Antibodies), GABRA2 and DRD2 (show DRD2 Antibodies) variants with transcranial magnetic stimulation measures of corticospinal excitability and cortical inhibition in Huntington's disease, as well as with age at onset.

  2. Our study findings showed COMT (show COMT Antibodies) polymorphism conferring risk and GABRA1 (show GABRA1 Antibodies) and GABRA2 polymorphism as a protective genotype for Indian male with alcohol dependence (AD)

  3. parental externalizing was associated with more life events, and the association between life events and subsequent adolescent externalizing varied as a function of GABRA2 genotype (p

  4. A GABRA2 x Parental Monitoring effect on externalizing behavior trajectory was observed, such that A-carriers were largely unaffected by parental monitoring, whereas trajectory for those with the GG genotype was affected by parental monitoring.

  5. GABRA2 SNPs directly predicted adolescent alcohol problems.

  6. Alcohol dependence-associated variation in GABRA2 is associated with differential expression of the entire cluster of GABAA (show GABRg1 Antibodies) subunit genes on chromosome 4p12 in neural stem cells.

  7. Recent drinking history (p = 0.01), and recent drinking history x genotype interaction (p = 0.01) were significantly associated with acute adaptation of the subjective responses to alcohol for the GABRA2 SNP rs279858.

  8. The results of this study support a growing body of evidence linking GABAA (show GABRg1 Antibodies) receptors with the development of alcohol tolerance, dependence and withdrawal symptoms

  9. GABRA2 is significantly associated with rule breaking in mid- to late adolescence, but not substance abuse symptomatology across adolescence.

  10. GABRA2 genetic variants play a role in antipsychotic-associated weight gain.

Mouse (Murine) gamma-aminobutyric Acid (GABA) A Receptor, alpha 2 (GABRA2) interaction partners

  1. Findings suggest that ovarian cycle-related progesterone and neurosteroids regulate alpha2-GABA-A receptor expression in the hippocampus via a non-progesterone receptor (show PGR Antibodies) pathway, which may be relevant to menstrual-cycle related brain conditions.

  2. Results show that the expression levels of Gabra2, as well as of GABA receptor-mediated inhibitory neurotransmission, are reduced in Shank2 (show SHANK2 Antibodies) e6-7, but not in e7 KO mice compared with their own wild type littermates. Shank2 (show SHANK2 Antibodies) e6-7 KO mice treated with allosteric modulator for the GABAA (show GABRg1 Antibodies) receptor reverses spatial memory deficits, indicating that reduced inhibitory neurotransmission may cause memory deficits in Shank2 (show SHANK2 Antibodies).

  3. Pharmological manipulation by clobazam, a common anticonvulsant with preferential affinity for the GABRA2 receptor, revealed dose-dependent protection against hyperthermia-induced seizures in Scn1a (show SCN1A Antibodies)+/- mice. These findings support Gabra2 as a genetic modifier of the Scn1a (show SCN1A Antibodies)+/- mouse model of Dravet syndrome.

  4. Results indicate that 174 proteins were associated with gamma-aminobutyric acid receptor subunit alpha 2 (pHalpha2).

  5. Wild-type and mutant mice have similar baseline nociceptive sensitivities and develop similar hyperalgesia specifically targeting alpha2-GABAA (show GABRg1 Antibodies) receptors which exert their antihyperalgesic effect through enhanced spinal nociceptive control.

  6. GABRA2 subunit expression in hippocampus modulates neurogenesis through nuclear factor of activated T cell (show NFATC3 Antibodies) (NFATc)4 (show NFATC4 Antibodies) activity.

  7. Disrupting the clustering of GABAA (show GABRg1 Antibodies) receptor alpha2 subunits in the frontal cortex leads to reduced gamma-power and cognitive deficits.

  8. Recovery of function following alcoholic intoxication is regulated by Gabra2 and Gabra3 (show GABRA3 Antibodies) receptor subunits.

  9. These findings suggest that alpha2-containing GABA(A) receptors expressed in the CA3 (show CA3 Antibodies) region provide the inhibition that controls hippocampal rhythm during cholinergically induced oscillations

  10. The results of this study emphasize the critical role of GABAergic synaptic signaling for structural maturation of adult-born GCs (show UGCG Antibodies) and formation of glutamatergic synapses.

GABRA2 Antigen Profile

Protein Summary

GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. Alternatively spliced transcript variants encoding the same protein have been found for this gene.

Gene names and symbols associated with GABRA2

  • gamma-aminobutyric acid (GABA) A receptor, alpha 2 (GABRA2) antibody
  • gamma-aminobutyric acid (GABA) A receptor, alpha 2 (gabra2) antibody
  • gamma-aminobutyric acid (GABA) A receptor, alpha 2 (Gabra2) antibody
  • gamma-aminobutyric acid (GABA) A receptor, subunit alpha 2 (Gabra2) antibody
  • C630048P16Rik antibody
  • Gabra-2 antibody

Protein level used designations for GABRA2

GABA(A) receptor subunit alpha-2 , gamma-aminobutyric acid receptor subunit alpha-2 , GABA-A receptor alpha-1 subunit , gamma-aminobutyric acid (GABA) A receptor, alpha 2 , gamma-aminobutyric acid A receptor alpha 2 , gamma-aminobutyric acid A receptor, alpha 2 precursor-like , GABA(A) receptor, alpha 2 , gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 2 , gamma-aminobutyric acid receptor A2 subunit , gamma-aminobutyric acid A receptor, alpha 2

GENE ID SPECIES
703894 Macaca mulatta
751992 Taeniopygia guttata
770511 Gallus gallus
100173835 Pongo abelii
100061914 Equus caballus
100170583 Xenopus (Silurana) tropicalis
100286789 Felis catus
100339376 Oryctolagus cuniculus
100546188 Meleagris gallopavo
2555 Homo sapiens
289606 Rattus norvegicus
447255 Xenopus laevis
482131 Canis lupus familiaris
282236 Bos taurus
461355 Pan troglodytes
14395 Mus musculus
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