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helicase 2, X-linked (ATRX) ELISA Kits

The protein encoded by ATRX contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. Additionally we are shipping ATRX Antibodies (94) and ATRX Proteins (4) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
ATRX 546 P46100
Anti-Rat ATRX ATRX 246284  
ATRX 22589 Q61687
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More ELISA Kits for ATRX Interaction Partners

Human helicase 2, X-linked (ATRX) interaction partners

  1. our study describes a novel missense mutation of the ATRX gene helicase domain, carried by three affected males of the two generations of the same family and segregated with intellectual deficiency, dysmorphism and behaviour disorder without alpha-thalassaemia and with non-skewed X-chromosome inactivation

  2. ATRX mutation is associated with increased mutation rate at the single-nucleotide variant (SNV) level.

  3. ATRX loss may predict better clinical outcome in astrocytoma patients with p53 (show TP53 ELISA Kits) overexpression as compared to patients with wild-type ATRX

  4. Loss of ATRX was highly associated with alternative lengthening of telomeres

  5. For WHO grade II diffuse glioma, molecular classification using 1p/19qcodel, IDHmut, and ATRX loss more accurately predicts outcome and should be incorporated in the neuropathologic evaluation.

  6. We provide an overview of the individual components (ATRX, DAXX and/or H3.3) tested in each study and propose a model where the ATRX/DAXX chaperone complex deposits H3.3 to maintain the H3K9me3 modification at heterochromatin throughout the genome.

  7. Frequent ATRX mutations and aberrant ATRX gene expression in uterine leiomyosarcomas.

  8. Daxx (show DAXX ELISA Kits) and Atrx safeguard the genome by silencing repetitive elements when DNA methylation (show HELLS ELISA Kits) levels are low.

  9. Loss of ATRX is associated with DNA methylation (show HELLS ELISA Kits) pattern of chromosome end and impacts biological behaviors of astrocytic tumors.

  10. Data identify MDM2 (show MDM2 ELISA Kits) and ATRX as new regulators controlling geroconversion, the process by which quiescent cells become senescent.

Mouse (Murine) helicase 2, X-linked (ATRX) interaction partners

  1. The changes of ATRX distribution occur and partially correlate with the main stages of zygotic genome activation during mouse early development, butthese changes seem to be determined by other processes of structural and functional rearrangements of blastomere nuclei.

  2. ATRX mutation is associated with increased mutation rate at the single-nucleotide variant (SNV) level.

  3. Daxx (show DAXX ELISA Kits) and Atrx safeguard the genome by silencing repetitive elements when DNA methylation (show HELLS ELISA Kits) levels are low.

  4. A direct role of Atrx in the establishment and robust maintenance of heterochromatin is demonstrated.

  5. We propose a model whereby ATRX-dependent deposition of H3.3 into heterochromatin is normally required to maintain the memory of silencing at imprinted loci.

  6. ATRX promotes the incorporation of histone H3.3 (show H3F3A ELISA Kits) at particular transcribed genes and facilitates transcriptional elongation through G-rich sequences.

  7. Using X chromosome inactivation as a model, study applied an unbiased proteomics approach to isolate Xist and PRC2 regulators and identified ATRX; ATRX functions as a high-affinity RNA-binding protein that directly interacts with RepA/Xist RNA to promote loading of PRC2 in vivo. Without ATRX, PRC2 cannot load onto Xist RNA nor spread in cis (show CISH ELISA Kits) along the X chromosome.

  8. These results indicate that while ATRX plays limited roles during early stages of skeletal development, deficiency of the protein in adult tissues does not confer susceptibility to osteoarthritis.

  9. ATRX plays a direct role in facilitating DNA replication. Ablation of ATRX alone, although leading to a DNA damage response at telomeres, is not sufficient to trigger the alternative lengthening of telomere pathway in mouse embryonic stem cells.

  10. The findings indicate that ATRX regulates gene expression at a subset of imprinted domains by maintaining a nucleosome configuration conducive to CTCF (show CTCF ELISA Kits) binding and to the maintenance of higher order chromatin structure.

ATRX Antigen Profile

Antigen Summary

The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. The mutations of this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.

Gene names and symbols associated with helicase 2, X-linked (ATRX) ELISA Kits

  • alpha thalassemia/mental retardation syndrome X-linked (ATRX) antibody
  • alpha thalassemia/mental retardation syndrome X-linked (Atrx) antibody
  • alpha thalassemia/mental retardation syndrome X-linked homolog (human) (Atrx) antibody
  • RAD54 like (S. cerevisiae) (Rad54l) antibody
  • 4833408C14Rik antibody
  • AI447451 antibody
  • ATR2 antibody
  • DXHXS6677E antibody
  • HP1-BP38 antibody
  • Hp1bp2 antibody
  • Hp1bp38 antibody
  • JMS antibody
  • MRXHF1 antibody
  • MRXS3 antibody
  • Rad54 antibody
  • RAD54L antibody
  • SFM1 antibody
  • SHS antibody
  • XH2 antibody
  • Xnp antibody
  • ZNF-HX antibody

Protein level used designations for helicase 2, X-linked (ATRX) ELISA Kits

ATP-dependent helicase ATRX , DNA dependent ATPase and helicase , X-linked helicase II , X-linked nuclear protein , Zinc finger helicase , alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae) , helicase 2, X-linked , transcriptional regulator ATRX , alpha thalassemia/mental retardation syndrome X-linked homolog , helicase II , pABP-2 , XNP , HP1 alpha-interacting protein , alpha thalassemia/mental retardation syndrome (X-linked) , heterochromatin protein 2 , DNA repair and recombination protein RAD54-like , RAD54 homolog , mHR54 , mRAD54

GENE ID SPECIES
100455265 Pongo abelii
546 Homo sapiens
246284 Rattus norvegicus
449625 Pan troglodytes
22589 Mus musculus
19366 Mus musculus
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