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helicase 2, X-linked Proteins (ATRX)

The protein encoded by ATRX contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. Additionally we are shipping ATRX Antibodies (89) and ATRX Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ATRX 546 P46100
ATRX 246284  
Mouse ATRX ATRX 22589 Q61687
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Top ATRX Proteins at antibodies-online.com

Showing 3 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Macropus eugenii His tag   1 mg Log in to see 56 to 66 Days
$3,408.17
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,501.67
Details

ATRX Proteins by Origin and Source

Origin Expressed in Conjugate
Human

Rat (Rattus)

More Proteins for helicase 2, X-linked (ATRX) Interaction Partners

Human helicase 2, X-linked (ATRX) interaction partners

  1. ATRX loss may predict better clinical outcome in astrocytoma patients with p53 (show TP53 Proteins) overexpression as compared to patients with wild-type ATRX

  2. Loss of ATRX was highly associated with alternative lengthening of telomeres

  3. For WHO grade II diffuse glioma, molecular classification using 1p/19qcodel, IDHmut, and ATRX loss more accurately predicts outcome and should be incorporated in the neuropathologic evaluation.

  4. We provide an overview of the individual components (ATRX, DAXX and/or H3.3) tested in each study and propose a model where the ATRX/DAXX chaperone complex deposits H3.3 to maintain the H3K9me3 modification at heterochromatin throughout the genome.

  5. Frequent ATRX mutations and aberrant ATRX gene expression in uterine leiomyosarcomas.

  6. Daxx (show DAXX Proteins) and Atrx safeguard the genome by silencing repetitive elements when DNA methylation (show HELLS Proteins) levels are low.

  7. Loss of ATRX is associated with DNA methylation (show HELLS Proteins) pattern of chromosome end and impacts biological behaviors of astrocytic tumors.

  8. Data identify MDM2 (show MDM2 Proteins) and ATRX as new regulators controlling geroconversion, the process by which quiescent cells become senescent.

  9. ATRX interacts with ZNF274 (show ZNF274 Proteins), TRIM28 (show TRIM28 Proteins) and SETDB1 (show SETDB1 Proteins) and binds to the 3' exons of zinc finger genes that present an atypical H3K9me3/H3K36me3 chromatin signature. Depletion of ATRX or ZNF274 (show ZNF274 Proteins) leads to decreased H3K9me3 levels at zinc finger genes and other atypical chromatin regions.

  10. ATRX loss was the most likely mechanism of alternative telomere lengthening in liposarcoma and alternative telomere lengthening was a prognostic factor of poor outcome in dedifferentiated liposarcoma.

Mouse (Murine) helicase 2, X-linked (ATRX) interaction partners

  1. Daxx (show DAXX Proteins) and Atrx safeguard the genome by silencing repetitive elements when DNA methylation (show HELLS Proteins) levels are low.

  2. A direct role of Atrx in the establishment and robust maintenance of heterochromatin is demonstrated.

  3. We propose a model whereby ATRX-dependent deposition of H3.3 into heterochromatin is normally required to maintain the memory of silencing at imprinted loci.

  4. ATRX promotes the incorporation of histone H3.3 (show H3F3A Proteins) at particular transcribed genes and facilitates transcriptional elongation through G-rich sequences.

  5. Using X chromosome inactivation as a model, study applied an unbiased proteomics approach to isolate Xist and PRC2 regulators and identified ATRX; ATRX functions as a high-affinity RNA-binding protein that directly interacts with RepA/Xist RNA to promote loading of PRC2 in vivo. Without ATRX, PRC2 cannot load onto Xist RNA nor spread in cis (show CISH Proteins) along the X chromosome.

  6. These results indicate that while ATRX plays limited roles during early stages of skeletal development, deficiency of the protein in adult tissues does not confer susceptibility to osteoarthritis.

  7. ATRX plays a direct role in facilitating DNA replication. Ablation of ATRX alone, although leading to a DNA damage response at telomeres, is not sufficient to trigger the alternative lengthening of telomere pathway in mouse embryonic stem cells.

  8. The findings indicate that ATRX regulates gene expression at a subset of imprinted domains by maintaining a nucleosome configuration conducive to CTCF (show CTCF Proteins) binding and to the maintenance of higher order chromatin structure.

  9. Targeted loss of the ATR-X syndrome protein in the limb mesenchyme of mice causes brachydactyly.

  10. loss of ATRX increases DNA damage locally in the forebrain and anterior pituitary and causes tissue attrition and other systemic defects similar to those seen in aging

ATRX Protein Profile

Protein Summary

The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. The mutations of this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.

Gene names and symbols associated with helicase 2, X-linked Proteins (ATRX)

  • alpha thalassemia/mental retardation syndrome X-linked (ATRX)
  • alpha thalassemia/mental retardation syndrome X-linked (Atrx)
  • alpha thalassemia/mental retardation syndrome X-linked homolog (human) (Atrx)
  • RAD54 like (S. cerevisiae) (Rad54l)
  • 4833408C14Rik protein
  • AI447451 protein
  • ATR2 protein
  • DXHXS6677E protein
  • HP1-BP38 protein
  • Hp1bp2 protein
  • Hp1bp38 protein
  • JMS protein
  • MRXHF1 protein
  • MRXS3 protein
  • Rad54 protein
  • RAD54L protein
  • SFM1 protein
  • SHS protein
  • XH2 protein
  • Xnp protein
  • ZNF-HX protein

Protein level used designations for helicase 2, X-linked Proteins (ATRX)

ATP-dependent helicase ATRX , DNA dependent ATPase and helicase , X-linked helicase II , X-linked nuclear protein , Zinc finger helicase , alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae) , helicase 2, X-linked , transcriptional regulator ATRX , alpha thalassemia/mental retardation syndrome X-linked homolog , helicase II , pABP-2 , XNP , HP1 alpha-interacting protein , alpha thalassemia/mental retardation syndrome (X-linked) , heterochromatin protein 2 , DNA repair and recombination protein RAD54-like , RAD54 homolog , mHR54 , mRAD54

GENE ID SPECIES
100455265 Pongo abelii
546 Homo sapiens
246284 Rattus norvegicus
449625 Pan troglodytes
22589 Mus musculus
19366 Mus musculus
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