helicase 2, X-linked (ATRX) ELISA Kits

The protein encoded by ATRX contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. Additionally we are shipping ATRX Antibodies (127) and ATRX Proteins (4) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human ATRX ATRX 546 P46100
Anti-Rat ATRX ATRX 246284  
Anti-Mouse ATRX ATRX 22589 Q61687
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More ELISA Kits for ATRX Interaction Partners

Human helicase 2, X-linked (ATRX) interaction partners

  1. Both primary Alternative lengthening of telomeres(ALT) -positive and ATRX/DAXX (show DAXX ELISA Kits)-negative PanNETs are independently associated with aggressive clinicopathologic behavior and displayed reduced recurrence-free survival. In contrast, ALT activation and loss of ATRX/DAXX (show DAXX ELISA Kits) are both associated with better overall survival in patients with metastases

  2. Whole-exome sequencing has identified recurrent mutations in the genes DAXX (show DAXX ELISA Kits) and ATRX, which correlate with loss of protein expression and alternative lengthening of telomeres (ALT).ALT and DAXX (show DAXX ELISA Kits)/ATRX loss in PanNETs was associated with shorter disease-free survival (DFS (show FST ELISA Kits)) and disease-specific survival (DSS (show NR0B1 ELISA Kits)) and likely plays a significant role in driving metastatic disease

  3. The results of this study support an important role for ATRX loss and acquisition of ALT in the biology of NF1 (show NF1 ELISA Kits)-associated gliomas, particularly diffuse and high-grade tumors developing in adults.

  4. We propose that mutations in alpha thalassemia-mental retardation syndrome X-linked (ATRX)/death-domain associated protein (DAXX (show DAXX ELISA Kits)) prime alternative lengthening of telomeres activation by disrupting telomeric heterochromatin.

  5. Structural and biochemical characterization of DAXX (show DAXX ELISA Kits)-ATRX interaction.

  6. Structural basis for DAXX (show DAXX ELISA Kits) interaction with ATRX.

  7. Review of research progress of TERT (show TERT ELISA Kits)-mediated and ATRX-mediated telomere maintenance and neuroblastoma (show ARHGEF16 ELISA Kits), especially high-risk tumors

  8. This study demonstrated the ATRX loss in glioneuronal tumors with neuropil-like islands.

  9. 6 cases of diffuse glioma that presented a diagnostic challenge due to conflicting IDH1 (show IDH1 ELISA Kits)/IDH2 (show IDH2 ELISA Kits), ATRX, and 1p/19q results.

  10. The chromatin remodeling enzyme ATRX is a regulator of therapy induced senescence and drives cells into this state via multiple mechanisms.

Mouse (Murine) helicase 2, X-linked (ATRX) interaction partners

  1. Gene expression changes in the Atrx-null retina indicate defective synaptic structure and neuronal circuitry, suggest excitotoxic mechanisms of neurodegeneration, and demonstrate that common targets of ATRX in the forebrain and retina may contribute to similar neuropathological processes underlying cognitive impairment and visual dysfunction in ATR-X syndrome.

  2. mosaic loss of ATRX expression in the central nervous system leads to endocrine defects and decreased body size and has a negative impact on learning and memory.

  3. The results suggest that ATRX is required to limit replication stress during cellular proliferation, whereas upregulation of PARP-1 (show PARP1 ELISA Kits) activity functions as a compensatory mechanism to protect stalled forks, limiting genomic damage, and facilitating late-born neuron production.

  4. Our study highlights the importance of the cooperation between Rad54 (show RAD54L ELISA Kits) and Mus81 (show MUS81 ELISA Kits) for mediating DNA DSB repair and restraining chromosome missegregation.

  5. The long noncoding RNA, TERRA (show DMRT2 ELISA Kits) can bind both in cis (show CISH ELISA Kits) to telomeres and in trans to genic targets; a large network of interacting proteins was defined, including epigenetic factors, telomeric proteins, and the RNA helicase, ATRX. TERRA (show DMRT2 ELISA Kits) and ATRX share hundreds of target genes and are functionally antagonistic at these loci: whereas TERRA (show DMRT2 ELISA Kits) activates, ATRX represses gene expression.

  6. The changes of ATRX distribution occur and partially correlate with the main stages of zygotic genome activation during mouse early development, butthese changes seem to be determined by other processes of structural and functional rearrangements of blastomere nuclei.

  7. ATRX mutation is associated with increased mutation rate at the single-nucleotide variant (SNV) level.

  8. Daxx (show DAXX ELISA Kits) and Atrx safeguard the genome by silencing repetitive elements when DNA methylation (show HELLS ELISA Kits) levels are low.

  9. A direct role of Atrx in the establishment and robust maintenance of heterochromatin is demonstrated.

  10. We propose a model whereby ATRX-dependent deposition of H3.3 into heterochromatin is normally required to maintain the memory of silencing at imprinted loci.

ATRX Antigen Profile

Antigen Summary

The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. The mutations of this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.

Gene names and symbols associated with helicase 2, X-linked (ATRX) ELISA Kits

  • ATRX, chromatin remodeler (ATRX) antibody
  • ATRX, chromatin remodeler (Atrx) antibody
  • RAD54 like (S. cerevisiae) (Rad54l) antibody
  • 4833408C14Rik antibody
  • AI447451 antibody
  • ATR2 antibody
  • DXHXS6677E antibody
  • HP1-BP38 antibody
  • Hp1bp2 antibody
  • Hp1bp38 antibody
  • JMS antibody
  • MRXHF1 antibody
  • MRXS3 antibody
  • Rad54 antibody
  • RAD54L antibody
  • SFM1 antibody
  • SHS antibody
  • XH2 antibody
  • Xnp antibody
  • ZNF-HX antibody

Protein level used designations for helicase 2, X-linked (ATRX) ELISA Kits

ATP-dependent helicase ATRX , DNA dependent ATPase and helicase , X-linked helicase II , X-linked nuclear protein , Zinc finger helicase , alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae) , helicase 2, X-linked , transcriptional regulator ATRX , alpha thalassemia/mental retardation syndrome X-linked homolog , helicase II , pABP-2 , XNP , HP1 alpha-interacting protein , alpha thalassemia/mental retardation syndrome (X-linked) , heterochromatin protein 2 , DNA repair and recombination protein RAD54-like , RAD54 homolog , mHR54 , mRAD54

GENE ID SPECIES
100455265 Pongo abelii
546 Homo sapiens
246284 Rattus norvegicus
449625 Pan troglodytes
22589 Mus musculus
19366 Mus musculus
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