You are viewing an incomplete version of our website. Please click to reload the website as full version.

phosphodiesterase 10A Proteins (PDE10A)

The protein encoded by PDE10A belongs to the cyclic nucleotide phosphodiesterase family. Additionally we are shipping PDE10A Antibodies (31) and PDE10A Kits (8) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PDE10A 10846 Q9Y233
PDE10A 23984 Q8CA95
PDE10A 63885 Q9QYJ6
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online

Top PDE10A Proteins at

Showing 6 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 39 to 44 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 39 to 44 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
HOST_Baculovirus infected Insect Cells Human GST tag   5 μg Log in to see 10 to 12 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   5 applications Log in to see 1 to 2 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days

PDE10A Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
Mouse (Murine)

Rat (Rattus)

More Proteins for phosphodiesterase 10A (PDE10A) Interaction Partners

Human phosphodiesterase 10A (PDE10A) interaction partners

  1. germline PDE10A mutations associated with hyperkinetic movement disorder

  2. We have demonstrated that de novo dominant mutations in PDE10A are the cause of a unique movement disorder characterized by benign childhood-onset chorea and typical MRI (show C7ORF49 Proteins) abnormalities of the striatum.

  3. cGMP PDE (show ALDH7A1 Proteins) isozymes, PDE5 (show PDE5A Proteins) and 10, are elevated in colon tumor cells compared with normal colonocytes, and inhibitors and siRNAs can selectively suppress colon tumor cell growth

  4. Longitudinal data in a cohort of patients with early Huntington disease (show HTT Proteins) found PDE10 to be a useful biomarker of disease progression.

  5. Lu AF33241 represents a novel PDE2A (show PDE2A Proteins)/PDE10A inhibitor tool which can penetrate the blood brain barrier.

  6. PDE10A activity in medium spiny neurons in Huntington's disease might still be high in critical subcellular compartments, despite the overall striatal PDE10A decrease measured using positron-emission tomography.

  7. HPRT (show HPRT1 Proteins)-deficiency alters cAMP/PKA signaling pathway, which is in part due to the increased of PDE10A expression and activi

  8. The present study is the first to demonstrate a central role of PDE10A in progressive pulmonary vascular remodeling.

  9. The data of this results supported a model whereby PDE10A trafficking and localization can be regulated in response to local fluctuations in cAMP levels.

  10. analysis of functional chimeras of the phosphodiesterase 5 and 10 tandem GAF domains

Mouse (Murine) phosphodiesterase 10A (PDE10A) interaction partners

  1. Through a combination of pharmacological and genetic tools, study provides convergent evidence of D2 (rather than D1) pathway dominant effects of PDE10A inhibition in rodents

  2. A knock-in mouse model carrying the homologous p.Tyr97Cys variant had decreased striatal PDE10A and also displayed motor abnormalities

  3. Its alteration leads to a cause of Huntington disease (show HTT Proteins).

  4. data show that PDE10A plays a pivotal role in striatal signaling and striatum-mediated salience attribution

  5. findings reveal a dynamic interplay between PDE10A activity, level of neuronal network depolarization and degree of dopaminergic tone in the ability of D1 receptors to facilitate the GABAergic transmission to SNpr neurons.

  6. PDE10A deficiency produces a decrease in caloric intake without affecting meal frequency, daytime versus nighttime feeding behavior, or locomotor activity.

  7. PDE10A-deficient mice showed changes in appetitively as well as aversively motivated responding, and in visuospatial learning and memory, which could not be reduced to neuromotor impairments.

  8. Observed suppression of PDE10A activity significantly inhibits gene expression in the striatum and predicts neuroprotective effects in models of Huntington's disease.

  9. findings suggest that PDE10A is involved in regulating striatal output, possibly by reducing the sensitivity of medium spiny neurons to glutamatergic excitation

  10. PDE10A knockout mice showed a significant change in striatal dopamine turnover, which was accompanied by an enhanced locomotor response to amphetamine

PDE10A Protein Profile

Protein Summary

The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase family. It plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This protein can hydrolyze both cAMP and cGMP to the corresponding nucleoside 5' monophosphate, but has higher affinity for cAMP, and is more efficient with cAMP as substrate. Alternatively spliced transcript variants have been described for this gene.

Gene names and symbols associated with phosphodiesterase 10A Proteins (PDE10A)

  • phosphodiesterase 10A (PDE10A)
  • phosphodiesterase 10A (Pde10a)
  • HSPDE10A protein
  • Pde10a3 protein

Protein level used designations for phosphodiesterase 10A Proteins (PDE10A)

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A , dJ416F21.1 (phosphodiesterase 10A) , phosphodiesterase 10A1 (PDE10A1) , PDE10A2 brain-specific isoform , dual-substrate cAMP and cGMP, cyclic nucleotide phosphodiesterase , testis-specific phosphodiesterase PDE10A2

10846 Homo sapiens
23984 Mus musculus
63885 Rattus norvegicus
Selected quality suppliers for PDE10A Proteins (PDE10A)
Did you look for something else?